Guangdong Academy of Medical Sciences

Value of spectral CT in differentiating post-treatment recurrence/residual tumor from inflammatory fibrosis in nasopharyngeal carcinoma

This prospective, single-center pilot study aims to investigate the potential value of spectral computed tomography (CT) in differentiating post-treatment recurrence/residual tumor from inflammatory fibrosis in patients with Nasopharyngeal Carcinoma (NPC). This prospective study...

Motor imagery enhances swallowing motor cortex excitability and activates sensorimotor regions: a TMS and fNIRS study

Action observation (AO) and motor imagery (MI) represent promising, non-invasive strategies for promoting neuroplasticity in motor rehabilitation by engaging the shared neural substrates of actual movement. However, their translation to swallowing rehabilitation, particularly for...

Associations of early-life exposure to PM2.5 mass and its components with childhood anemia: A cross-sectional study in China, India, and Africa

Childhood anemia remains a major public health concern, but evidence regarding the associations of early-life exposure to PM 2.5 mass and its components with childhood anemia across regions remains limited. We conducted a cross-sectional study of 449,894 children under 5 years fr...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Integrated proteomic, transcriptomic, and epigenomic profiling identifies SRA1 as a novel therapeutic target for postpartum depression

Postpartum depression (PPD) is among the most common complications of childbirth, and identifying novel treatments is vital. We aimed to identify potential drug targets for PPD by integrating the plasma proteome, transcriptome and epigenome. We designed a comprehensive analysis p...

Intradural extramedullary venous hemangioma mimicking meningioma: a case report and literature review

Abstract Background Intradural extramedullary hemangiomas of the spinal canal are rare, and the venous subtype is particularly uncommon. Their imaging appearance can overlap with more frequent intradural extramedullary tumors, which increases the risk of misdiagnosis. This case r...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...

Temporal associations between severe infection and long-term risk of incident arrhythmias: a population-based cohort study

The long-term impact of severe infection on arrhythmia risk across the cardiac rhythm spectrum remains incompletely characterized. We investigated the association between hospital-treated infection and incident arrhythmias, examining temporal patterns, pathogen and site specifici...

Time-dependent anti-Müllerian hormone dynamics during GnRHa-based endocrine therapy in young breast cancer survivors: a longitudinal real-world cohort study

Abstract Background Anti-Müllerian hormone (AMH) is widely used to assess ovarian reserve in young women with breast cancer. However, its interpretation during gonadotropin-releasing hormone agonist (GnRHa)-based endocrine therapy remains challenging because pharmacologic ovarian...

Cardiac MR Characterization of Infarct‐Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction

BACKGROUND: Patients with multivessel disease (MVD) after acute myocardial infarction (AMI) have worse outcomes than those with single-vessel disease (SVD), but whether MVD is associated with diffuse myocardial injury beyond the infarct zone (IZ) remains unclear. PURPOSE: To char...

Thyroid function and hypertensive disorders of pregnancy: Insights from a sex‐specific cohort study, Mendelian randomization, and experimental validation

OBJECTIVE: To investigate the association of a history of hypertensive disorders of pregnancy (HDP) and a higher risk of cardiovascular disease using a sex-specific cohort study, bidirectional two-sample Mendelian randomization (MR), and in vitro experiments. METHODS: Multivariab...

Methylation-sensitive restriction endonuclease-based amplification assay for detecting DNA methylation in colorectal cancer: a cross-sectional study

Abstract Background This study evaluates the clinical utility of combined SDC2 and ADHFE1 methylation analysis for colorectal cancer (CRC) detection using a methylation-sensitive restriction endonuclease (MSRE)-based assay. Methods Leveraging the specificity of MSRE, we developed...

Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study

Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population. We conducted a 6-month prospective cohort...