Glostrup Hospital

Variable proficiency attainment following virtual reality cataract training: Implications for a mastery learning approach

PURPOSE: Virtual reality simulation (VRS)-based training is widely used to prepare novice cataract surgeons, yet unstandardized training regimens result in variable competence at the transition to surgery. In many settings, training follows a directed self-regulated learning appr...

Higher plasma vitamin D levels are not causally associated with less age‐related macular degeneration

PURPOSE: Higher levels of plasma 25-hydroxyvitamin D have been associated with a lower risk of age-related macular degeneration (AMD). We investigated observational and potential causal associations of plasma 25-hydroxyvitamin D with the risk of AMD in two large contemporary popu...

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and met...

Pharmacological Analysis of P2Y Purinergic Receptors That Modulate the Rat Vasopressor Sympathetic Tone

Background/Objectives: Adenosine 5′-O-(β-thio)-diphosphate (ADPβS) is a stable analogue of adenosine diphosphate (ADP). In pithed rats, ADPβS produces (i) inhibition of both the cardioaccelerator sympathetic tone (via prejunctional P2Y12/P2Y13 receptors) and the vasodepressor sen...

Communication Support and Training for Families Affected by Aphasia: A National Survey Exploring Perspectives of Professionals

BACKGROUND: Aphasia affects both the individuals and their families, impacting communication, social connectedness, roles and mental health. The focus in neurorehabilitation often remains on the individual, yet research suggests that addressing the family as a system would be ben...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast mi...

The efficacy of ketogenic interventions on neuropsychological & metabolic outcomes in serious mental illness & neurocognitive disorders: a systematic review & meta-analysis

Ketogenic interventions have garnered attention for their potential benefits in individuals with psychiatric and neurocognitive disorders. This review analyzed findings from studies investigating the impact of ketogenic interventions on clinical outcomes in individuals with serio...

Evaluation of a human slow-release buprenorphine formulation in rats – tactile sensitivity and plasma concentration

Abstract Background Opioids are considered ideal for managing moderate to severe post-operative pain in laboratory rodents, with buprenorphine being one of the most commonly used analgesics in rats. A long-acting buprenorphine formulation would be highly beneficial to avoid frequ...

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

Abstract The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links...

Nerve Injury Following Birth, the Role of Epidural Analgesia—A Protocol for a Scoping Review

BACKGROUND: Epidural analgesia is widely used during labor, and postpartum nerve injury is an uncommon but clinically relevant outcome. Neurological symptoms after childbirth may be related to obstetric or anesthetic factors. Studies vary considerably in how postpartum nerve inju...