Georgetown University

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

Integrating menopausal neurocognitive and psychosocial dynamics into economic behavior: the Behavioral Finance–Menopausal Cognition (BF-MC) Model (MARiE WP2A study)

Objective: Traditional behavioral finance—which examines how cognitive biases, emotions, and context shape economic decision-making— often assumes cognitive stability, rationality, and consistent risk evaluation, based largely on male-dominated samples. Emerging evidence from the...

Healthcare providers’ perceptions and prescribing behaviors of short-term prevention treatment of migraine in the United States

AIMS: Short-term prevention (STP) therapies are used to prevent migraine during anticipated exposure to known triggers. However, little is known about healthcare providers' (HCPs) attitudes and prescribing practices regarding STP. This study aimed to characterize real-world STP t...

Experience-driven plasticity in the secondary somatosensory cortex in people born without hands

In congenital handlessness, where individuals rely on their feet for compensatory manual functions, reorganization in the primary somatosensory cortex (SI) appears to be limited to local shifts by adjacent body parts. It remains unclear how congenital handlessness and lifelong co...

Propaganda, Administrative Deformation, and the Erosion of State Capacity: The Case of the “Censorship Industrial Complex”

ABSTRACT This paper examines how a propaganda frame alleging the existence of a “Censorship Industrial Complex” was institutionalized and then helped justify the dismantling of US election information resilience infrastructure across multiple federal agencies. Drawing on document...

Balancing altruism, risk and ethics: Vietnamese students’ views on human challenge studies

Introduction Human challenge studies (HCS) have been proposed to accelerate the development of health interventions and strengthen research capacity in low- and middle-income countries. However, implementation in settings such as Vietnam, where clinical care facilities and resear...

Hallucinations in organization-backed AI advisors: Evidence about skepticism, verification, and reliance in goal-directed use

Generative artificial intelligence (GenAI) systems are increasingly used by organizations to deliver information to consumers, patients, students, employees, and citizens. These systems can hallucinate, producing plausible but inaccurate responses. A central question for AI-advis...

Inpatient Dermatology and Re-emerging Infectious Diseases: Measles, Varicella, and Beyond

Abstract Purpose of Review Re-emerging infectious diseases are increasingly encountered in the inpatient setting and are important to recognize due to their transmissibility as well as their potential for morbidity and mortality. Inpatient dermatologists are well positioned to re...

Management strategies in endogenous fungal endophthalmitis: a multi-institutional retrospective cohort study

Background/aims Standardised treatment guidelines for endogenous fungal endophthalmitis (EFE) are lacking. The purpose of this study is to describe treatment strategies and clinical outcomes of eyes with EFE. Methods Retrospective cohort study performed at eight academic institut...

Breast cancer risk, epigenetic aging and DNA methylation clocks

Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among women in the United States, and is globally a common and impactful cancer. Its distinct molecular subtypes, each defined by characteristic genomic and epigenomic profiles, var...

Transforming home-based primary care through mHealth integration: associations with efficiency and acute care utilisation

Objective The objective of this study is to evaluate the real-world associations between implementation of the CareHub mHealth platform and operational efficiency, service delivery and acute care utilisation in a physician-led home-based primary care (HBPC) clinic. Methods We con...

Cervical cancer prevention and control strategy in Ethiopia: key informant clinicians’ perspective

Abstract Background: Cervical cancer is a major public health burden in Ethiopia, ranking second among women and disproportionately affecting HIV-positive individuals. In 2020, an estimated 7,445 new cases and 5,338 deaths occurred. Thus, accurate diagnosis, treatment, and pallia...

Intermediate risk thyroid cancer management: physician survey

Abstract Context Variability exists in use of radioactive iodine (RAI) treatment in intermediate risk (IR) thyroid cancer. Objective The study surveyed clinicians about their use of RAI in theoretical cases of patients with IR thyroid cancer. Design A survey presented patient cas...

Algorithms and ABCs: Associations between US parents’ educational media motivations and content quality on YouTube

YouTube usage among young children is highly prevalent, but prior content analyses suggest that YouTube contains substantial amounts of low educational content. We examined associations between parental motivations to use media to educate, child YouTube usage, and educational con...

Low depth unitary coupled cluster algorithm for large chemical systems

The unitary coupled cluster (UCC) algorithm is one of the most promising implementations of the variational quantum eigensolver for quantum computers. However, for large systems, the number of UCC factors leads to deep quantum circuits, which are prohibitive for execution on quan...

A time-to-event analysis to conceptualize and predict delay in type 2 diabetes diagnosis in primary care

Delayed diagnosis of type 2 diabetes (T2D) increases the risk of diabetes-related health complications. Although signs of T2D are commonly identified in primary care, delays in diagnosis remain a significant challenge. The relationship between patient-level factors (e.g., demogra...

Temporally structured motor and auditory representations in covert syllable production

Inner speaking—the deliberate generation of speech through covert production mechanisms—is a common human experience. Current accounts propose that it engages sensorimotor processes similar to those underlying overt speech. Here, we asked whether motor and auditory representation...

Schizophrenia: advances in pathophysiology, management, and precision medicine

Abstract Schizophrenia is a common and severe mental condition with onset usually in late adolescence and young adulthood. Schizophrenia is caused by a combination of multiple genetic and environmental factors with significant neurodevelopmental implications. Advances in the clin...

Effects of ketone supplementation on metabolic and hormonal profiles in polycystic ovary syndrome

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by metabolic dysfunction, hyperandrogenism, and reproductive hormone imbalance. This meta-analysis aimed to evaluate the effects of ketone supplementation on anthropometric, metabolic, and h...

Economic and Environmental Implications of Ride-Hailing and Vehicle Age Limits for Car Sales Markets

Problem definition: Ride-hailing poses significant challenges to Original Equipment Manufacturers (OEMs) as it offers an affordable mobility option, and thus may lead to lower new car ownership. Yet, its more intense competition with the sales of used cars in secondary markets (a...