Gazi University

Therapeutic Effects of Ganoderma lucidum Against Aβ-Induced Neurotoxicity in SH-SY5Y Cells: In Vitro Evidence and Computational Validation of Human Protein Targets

The triterpenoid and polysaccharide constituents of Ganoderma lucidum (GL) are believed to influence key pathogenic pathways in Alzheimer’s disease (AD). This study first examined the molecular rationale for GL’s neuroprotective properties by subjecting its principal triterpenoid...

Overuse Injuries of the Hip and Pelvis: Apophysitis, Stress Fractures, and Tendinopathies

Abstract Hip and pelvic overuse injuries are a frequent source of pain and lost playing time in athletes and may be challenging to diagnose because of overlapping symptoms and complex regional anatomy. Injury patterns vary according to skeletal maturity: in adolescents, open apop...

Machine Learning and Blockchain in Peer-to-Peer Energy Trading: A Cross-Layer Review of Functional Roles, Market Operation, Trust, and Privacy

Peer-to-peer (P2P) energy trading combines local energy resources, market coordination, data-driven decisions, and transaction management. This review examines how machine learning (ML) and blockchain are used across these functions and separates market and ledger processes from...

Scleral buckling versus combined pars plana vitrectomy and scleral buckling in primary rhegmatogenous retinal detachment: a 20-year retrospective comparative study

Scleral buckling (SB) has been progressively displaced by pars plana vitrectomy (PPV) in the management of rhegmatogenous retinal detachment (RRD); however, this transition appears to be driven more by evolving surgical training patterns than by clear differences in outcome data....

Posterior mediastinal unicentric Castleman disease treated by video-assisted thoracoscopic surgery

Castleman disease (CD) represents an uncommon lymphoproliferative condition that can manifest as a mediastinal mass and resemble other thoracic pathologies. Establishing a definitive diagnosis before surgery is often difficult, making histopathological analysis crucial. We presen...

Assessment of Knowledge, Clinical Experience, and Clinical Decision-Making Regarding Coronectomy of Mandibular Third Molars Among General Dentists and Oral and Maxillofacial Surgeons: A Cross-Sectional Survey

Background/Objectives: Coronectomy is a nerve-preserving alternative for mandibular third molars at high risk of inferior alveolar nerve injury. However, coronectomy-related knowledge, clinical experience, treatment preferences, and self-reported decision-making confidence may di...

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their c...

Association between PhenoAge-assessed biological age and survival outcomes in solid tumor patients treated with immune checkpoint inhibitors

Abstract Background Chronological age may influence immune function, but individuals of the same age may differ in biological aging. We evaluated the association between biological age and clinical outcomes in patients with solid tumors treated with immune checkpoint inhibitor mo...

Mechanical and surface properties of PMMA denture base resins fabricated by compression molding, fluid resin, milling, and 3D printing techniques

Different fabrication techniques for polymethyl methacrylate (PMMA) denture base resins may influence their mechanical and surface properties as well as their resistance to thermal aging. However, studies comprehensively comparing the mechanical and surface properties of conventi...

Caregiver burden, coping strategies, and problem-solving skills among parents of children with tracheostomy: a cross-sectional study

Caring for children with tracheostomy poses significant challenges, affecting caregivers’ cognitive, emotional, and physical well-being. This study aimed to assess caregiver burden, coping strategies, and problem-solving skills in mothers and fathers and to examine their relation...

Associations of cognitive beliefs and metacognitive processes with eating behavior in adults with obesity and healthy-weight controls: a cross-sectional study

Emotional and uncontrolled eating are common in obesity and may persist despite pharmacological or surgical treatment. Automatic thoughts and metacognitive beliefs may contribute to maladaptive eating, but have rarely been examined together while accounting for depression, anxiet...

The Role of Resilience in Relation to Depression, Anxiety, Stress, and Post-Traumatic Stress Symptoms Among Syrian Refugee Adolescents in Türkiye

Objectives: Mental health problems and post-traumatic stress symptoms are prevalent among adolescent refugees, yet little is known about the role of resilience in relation to these difficulties among Syrian adolescents. This study examined the unique contribution of resilience to...

Egg Chorion Morphology and Egg‐Laying Behaviour of Backswimmer Notonecta viridis Delcourt, 1909 (Heteroptera: Nepomorpha: Notonectidae)

ABSTRACT In this study, the egg‐laying behaviour and chorionic morphology of the eggs of the backswimmer Notonecta viridis Delcourt, 1909 (Heteroptera: Notonectidae) were described in detail using stereo, light and electron microscopy. Female N. viridis lays its eggs individually...

Artificial intelligence-assisted performance prediction of Francis turbine

Purpose The purpose of this study is to assess the technical and economic feasibility of integrating a Francis-type micro-hydropower turbine into a pressurized drinking water pipeline using data-driven performance prediction. Daily flow rate time series are forecast using deep le...

Phytochemical profile, antioxidant capacity, and carbonic anhydrase inhibition of Olea europaea L. (cv. Gemlik and Ayvalik) leaves: a green extraction approach

The extraction of medicinal plants has received attention due to their antioxidant and enzymatic properties and their potential in herbal remedies. In this study, the antioxidant activity, inhibitor effect of the carbonic anhydrase enzyme, and phytochemical content of two differe...

Posttraumatic growth in kidney and liver donors and recipients: a systematic review

Background Posttraumatic growth (PTG) describes positive psychological changes following highly stressful events, including organ transplantation. Kidney and liver transplantation improve survival but pose significant psychosocial challenges for recipients and living donors. Unde...

Prognostic factors after pulmonary metastasectomy for colorectal cancer lung metastasis

Objective: Surgical resection of lung metastases in patients with colorectal cancer (CRC) can provide long-term survival in selected cases. This study aimed to evaluate the prognostic factors affecting survival after pulmonary metastasectomy (PM) performed for lung metastases due...

Etelcalcetide Versus Cinacalcet for Secondary Hyperparathyroidism in Hemodialysis Patients: A Multicentre Comparison with 24 Months of Follow-Up

Background/Objectives: Secondary hyperparathyroidism (SHPT) is a prevalent complication of end-stage kidney disease. Although etelcalcetide has demonstrated short-term superiority over cinacalcet in randomized trials, real-world comparative data beyond 12 months remain scarce. Th...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

The effects of nanoparticle usage as an additive into diesel-microwave-assisted corn oil biodiesel-oxygenated dibutyl maleate fuel mixtures on combustion, performance and emissions

In the current research, the role of nanoparticles in microwave-assisted corn oil biodiesel–dibutyl maleate (DBM) blends was analyzed with respect to combustion behavior, engine performance, and emissions. A single-cylinder DI diesel engine was operated at 2200 rpm and 4.12, 9.61...