Gansu University of Traditional Chinese Medicine

Diagnostic value of neutrophil extracellular traps in community-acquired pneumonia and their potential in identifying mixed infection

Abstract Objective To explore the expression characteristics of neutrophil extracellular traps (NETs) in patients with community-acquired pneumonia (CAP), and analyze the diagnostic value of NETs as well as their correlation with different infection patterns in CAP. Methods A tot...

Histological significance of MPO, ER, and PR in endometrial polyps of premenopausal women.

BACKGROUND: Endometrial polyps (EP) can lead to irregular bleeding and infertility in women. The identification of biomarkers associated with EP holds clinical importance. METHODS: Patients who visited the hospital due to abnormal uterine bleeding, endometrial thickening, abnorma...

Exogenous SA- and IAA-Mediated Regulation of Silique Growth and Development in Isatis indigotica

Isatis indigotica Fort.—a well-known medicinal cruciferous species—is the source plant of Isatidis Radix and Folium Isatidis, and is widely cultivated for medicinal raw material. The silique serves as the propagative organ for seed production of I. indigotica, and its development...

Investigation of the transcription factor TEAD-based material basis of Astragalus synergistic dacarbazine in the treatment of uveal melanoma

Abstract Uveal melanoma (UM) is the most common intraocular malignancy in adults, and despite great advances in combination drug therapies based on UM-related pathways, targeted therapies remain an unmet medical need, and there has been a decrease in sensitivity to chemotherapy....

The complete chloroplast genome sequence of Elatostema involucratum

Elatostema involucratum Franch. & Sav, a perennial herb in the genus Elatostema (family Urticaceae), has significant medicinal value. Here, we report the complete chloroplast genome of E. involucratum for the first time, assembled using high-throughput sequencing. The chloroplast...

Global Trends in Heart Failure Self-Care Research: A Bibliometric and Visual Analysis

Background: Adequate patient self-care is fundamental to effective heart failure (HF) management and is endorsed by international guidelines to improve clinical outcomes. Despite a growing body of evidence, the global research landscape, including publication trends, collaborativ...

Research Progress of Autophagy and Ferroptosis in Endometriosis.

to clarify the mechanisms of autophagy，ferroptosis，and their interaction in the occurrence and progression of EMs can not only delve into the invasion and migration processes of ectopic lesions in the pelvis and abdomen but also provide new ideas and targets for the treatment o...

Integrated proteomic and metabolomic analysis identifies complement activation and metabolic alterations in the serum of patients with idiopathic membranous nephropathy: an exploratory study

Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults, yet its pathogenesis remains incompletely understood. This exploratory study aimed to characterize serum molecular profiles in IMN patients by integrating proteomics and metabolomics analys...

Recurrent intraoperative asystole induced by tumor manipulation in a cervical vagal schwannoma: a case report

<title>Abstract</title> <bold>Background:</bold> Vagal schwannomas are rare, benign tumors arising from Schwann cells of the vagus nerve. Surgical resection is the mainstay of treatment but carries significant risks, including intraoperative hemodynamic instability due to vagal n...

Exploratory analysis of the impact of age stratification on outcomes of combined Salter osteotomy and femoral osteotomy in pediatric developmental dysplasia of the hip using a 3-year cutoff

Abstract Objective This study compared outcomes of combined Salter osteotomy, open reduction, and proximal femoral osteotomy in developmental dysplasia of the hip (DDH) children under 3 years versus those aged 3 years or older. Methods This retrospective study analyzed 65 DDH pat...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...

Efficacy and safety of combined intravenous and topical tranexamic acid in primary total hip arthroplasty: a meta‑analysis and systematic review of randomized controlled trials

Both intravenous (IV) and topical tranexamic acid (TXA) reduce bleeding in total hip arthroplasty (THA), but the added benefit of combining the two routes and the potential modifying effect of topical dose remain unclear. We performed a systematic review and meta‑analysis of RCTs...

Delayed rupture of vaginal wall haematoma causing secondary postpartum haemorrhage—successful management with bilateral uterine artery embolisation: a case report

Secondary postpartum haemorrhag (PPH), defined as excessive bleeding occurring between 24 hours and 6 weeks after delivery, is less common than primary PPH but may cause substantial maternal morbidity if diagnosis or intervention is delayed. Vaginal wall haematomas are usually re...

Prognostic utility of the Charlson comorbidity index in pancreatic cancer: a systematic review and meta‑analysis

The prognosis of pancreatic cancer is extremely poor, and patients frequently present with multiple comorbidities. The Charlson Comorbidity Index (CCI) and its age-adjusted version (CACI) are widely used to quantify the burden of comorbidity. This systematic review and meta-analy...

Quercetin Activates NRF2/SLC7A11/GPX4 Signaling to Restore Mitochondrial Function Inhibit Ferroptosis Thereby Alleviating Doxorubicin-Induced Cardiotoxicity

Background: As a common clinical anticancer drug, doxorubicin (DOX) easily triggers obvious doxorubicin-induced cardiotoxicity (DIC) during clinical application. Accumulating evidence has proven that ferroptosis dominates the pathological process of DIC yet efficient targeted tre...

Associations of QCT-derived body composition parameters with HOMA-IR-defined metabolic burden in patients with type 2 diabetes mellitus: a retrospective cross-sectional study

Insulin resistance is central to type 2 diabetes mellitus (T2DM) and is linked to abdominal adiposity, ectopic fat deposition, and skeletal muscle metabolism. However, HOMA-IR is a fasting surrogate measure that may be influenced by endogenous insulin secretion and treatment stat...

Hydrogen Sulfide-Regulated NF-κB Signaling via Persulfidation: A Review

Hydrogen sulfide (H2S) is an important endogenous gaseous signaling molecule that regulates diverse physiological and pathological processes through protein persulfidation. As a central regulator of inflammation and immune responses, NF-κB signaling is precisely controlled by pos...