Gangnam Severance Hospital

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Cost-effectiveness of 5.0 μm inline intravenous filtration in surgical inpatients using a decision tree and Markov model

Phlebitis is a common complication of intravenous (IV) therapy, especially in vulnerable populations such as surgical inpatients. Despite being frequently overlooked due to its typically mild presentation, phlebitis may lead to severe complications in high-risk patients. This stu...

Ketogenic Dietary Therapies and β-Hydroxybutyrate as Modulators of Mitochondrial Function: From Molecular Mechanisms to Clinical Translation

Ketogenic dietary therapies (KDTs) have been used for a century in drug-resistant epilepsy, and β-hydroxybutyrate (BHB), the major ketone body, is recognized as a signaling metabolite. This review examines how KDTs and BHB modulate mitochondrial function and evaluates evidence su...

The landscape of allele-specific expression in human kidneys

Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome...

Health-related quality of life in patients with spinal muscular atrophy receiving nusinersen and their caregivers: a cross-sectional study

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterized by progressive motor decline. Although nusinersen has improved survival and motor outcomes, patients and caregivers continue to face substantial medical and psychosocial challenges. As treatment goals ha...

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Comparison of stool DNA–based SDC2 methylation testing and repeat fit for advanced colorectal neoplasia in fit-positive individuals: a multicenter prospective exploratory study

Abstract Background and Aim Fecal immunochemical test (FIT)–based colorectal cancer (CRC) screening is limited by false-negatives due to bleeding dependence and a high false-positive burden. We compared the diagnostic accuracy of stool DNA–based SDC2 methylation testing versus re...

Beyond the algorithm: what makes artificial intelligence-assisted colonoscopy effective in routine practice?

Effectiveness of a novel artificial intelligence-assisted colonoscopy system for adenoma detection: a prospective, propensity score-matched, non-randomized controlled study in Korea ENAD-assisted colonoscopy significantly improved the ADR, APC, and SSLDR in real-world clinical pr...

Factors influencing patient satisfaction in adult thoracolumbar deformity surgery: a single-center retrospective study

Objective: This study aimed to identify demographic and radiographic factors associated with patient satisfaction after adult thoracolumbar deformity surgery using a single-center retrospective database.Methods: Data were collected from 2014 to 2021.Of 359 patients screened, 107...

Short‐Term Changes in the Occlusal Contacts During Anterior Segmental Orthodontic Treatment With Clear Aligners in Adult Patients

ABSTRACT Objective To compare ClinCheck‐predicted and achieved maxillary occlusal contact areas immediately after an initial 14‐aligner anterior segmental sequence without programmed posterior movement. Materials and Methods This retrospective study included 31 adult women treate...

Optimal gating envelope size for automatic gating in magnetic resonance imaging–guided radiotherapy

Purpose This study aimed to investigate the optimal gating envelope (GE) size for automatic gating in magnetic resonance imaging–guided radiotherapy (MRIgRT) for liver cancer. Methods This study retrospectively analyzed imaging and radiation treatment data from ten patients with...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Association of Placental Tissue S100A14 Expression with Histologic Chorioamnionitis in Preterm Birth

Background/Objectives: S100A14 has been implicated in cellular signaling and tissue remodeling, but its relationship with histologic chorioamnionitis (HCA) remains unknown. We evaluated its placental expression and discriminatory performance for HCA in preterm birth. Methods: Thi...

Preferences and reasons for clothing colors in women patients and survivors of breast cancer in Korea

Purpose Clothing color can affect the psychological aspects in female patients and survivors of breast cancer; however, little is known regarding their preferences and reasons for choosing specific clothing color. This study aimed to explore the factors influencing their clothing...

Diagnosing patulous Eustachian tube dysfunction using the nine-step and inflation tests

This study evaluated the diagnostic value of the nine-step test and an inflation test for patulous Eustachian tube (PET). We prospectively analyzed 27 ears from 18 patients with definite PET who underwent ventilation tube insertion, and 18 ears from 18 control participants with t...

Genomic Reanalysis of Neurodevelopmental Disorders With and Without Epilepsy: Diagnostic Yield and Mechanisms of Newly Established Diagnoses

Background/Objectives: Genomic reanalysis may provide additional molecular diagnoses in patients with neurodevelopmental disorders (NDDs) whose initial genetic testing was nondiagnostic. We evaluated the diagnostic yield and mechanisms of newly established diagnoses in NDDs with...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Prognostic Score Model for 30-Day Mortality in Patients with Acute Pulmonary Embolism Presenting to the Emergency Department

Background/Objectives: Early risk stratification is essential in pulmonary embolism (PE), but a simple tool integrating routinely available clinical and laboratory variables is lacking. We aimed to develop a simple score for predicting 30-day mortality in patients presenting to t...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Quantitative Analysis of Automatically Segmented Perivascular Space in Subcortical White Matter of Parkinson’s Disease: Its Clinical Relevance

Objective: To examine the relationship between automatically quantified perivascular space (PVS) extent located in the subcortical white matter (WM), baseline motor deficits and cognitive function, as well as longitudinal motor and cognitive outcomes in patients with Parkinson's...