Fukushima Medical University

Cardiac asystole during creation of a retroperitoneal working space with a balloon dissector in retroperitoneal laparoscopic nephrectomy: a case report

Abstract Background Although cardiac asystole during balloon dilation to create a retroperitoneal working space has been reported in endoscopic extraperitoneal radicalprostatectomy, it is quite rare during retroperitoneal nephrectomy. We report such a case. Case presentation An 8...

Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening

Abstract The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection aga...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Dishevelled2 Negatively Regulates Cell‐Surface Ror1 Abundance Through Lysosomal Degradation

ABSTRACT Receptor tyrosine kinase‐like orphan receptor 1 (Ror1) mediates Wnt5a‐dependent noncanonical Wnt signaling and promotes lung adenocarcinoma progression. Dishevelled (Dvl) proteins are central mediators of Wnt signaling and have also been implicated in its negative regula...

Diagnostic accuracy of 18F-PSMA-1007 PET/CT and bone scintigraphy for detecting bone metastases in prostate cancer

Abstract Objective The performance of 18 F-labeled prostate-specific membrane antigen ( 18 F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared. Materials and metho...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Comparison of submacular hemorrhage incidences under aflibercept and faricimab treat-and-extend regimens in neovascular age-related macular degeneration

Abstract Background We aimed to compare the incidences of submacular hemorrhage (SMH) under two treat-and-extend regimens with aflibercept (IVA) and faricimab (IVFa) in patients with neovascular age-related macular degeneration (nAMD) and to perform exploratory analyses of age-st...

Small modular reactors and our ecosystems – engagement, transparency & trust; summary of a workshop held at McMaster University, Canada

Purpose: Globally, governments are launching national programs, demonstration projects and industrial partnerships to bring small modular reactors (SMR) to market as lower-carbon, more flexible forms of nuclear power. Current international assessments suggest the first wave of co...

Neurodevelopmental Trait Subgroups in Medically Unexplained Oral Symptoms: A Retrospective Observational Study

Introduction and aims Medically unexplained oral symptoms (MUOS) are heterogeneous conditions with prominent subjective complaints despite limited objective findings. We examined whether autism spectrum disorder (ASD)- and attention-deficit/hyperactivity disorder (ADHD)-related t...

Impact of adjuvant chemotherapy on renal impairment patients following radical nephroureterectomy in upper tract urothelial carcinoma: a multicenter retrospective study

Abstract To evaluate the impact of adjuvant platinum-based chemotherapy (AC) on oncological outcomes in high-risk upper tract urothelial carcinoma (UTUC) patients with postoperative renal impairment following radical nephroureterectomy (RNU). Among 1050 patients who underwent RNU...

When an AI-generated diagnosis begins to matter: the AI consequence point

A patient can arrive at a consultation already organised around an AI-generated disease name. When does that use become relevant to diagnostic quality and safety - not merely to AI adoption? We define the AI consequence point: the first identifiable moment at which a patient's pr...

Functional Assessment of Platelet‐Derived Phospholipid Activity in Pooled Normal Plasmas by Low‐Phospholipid Thrombin Generation Assay and Its Impact on Lupus Anticoagulant Mixing Tests

ABSTRACT Background Pooled normal plasma (PNP) used for lupus anticoagulant (LA) mixing tests may carry platelet‐derived phospholipid (PL) activity introduced during freezing/lyophilization, potentially attenuating LA‐mediated prolongation of clotting times. Objectives To determi...

Association of adjustability of grasping force in dominant and nondominant hands with physical and cognitive function in community-dwelling older adults: a cross-sectional study

Abstract Background Adjustability of grasping force (AGF) is essential for activities of daily living (ADL) and instrumental ADL. However, its association with physical and cognitive functions in older adults, and whether these associations differ by hand remain unclear. Therefor...

Evaluation of the UK Myeloma Research Alliance risk profile in transplant‐ineligible multiple myeloma patients treated with novel agents

Summary The heterogeneity of multiple myeloma (MM) significantly impacts treatment outcomes. Myeloma risk profile (MRP), introduced by the UK Myeloma Research Alliance, is a novel prognostic model for patients with transplant‐ineligible newly diagnosed MM (TIE‐NDMM) utilizing eas...

Differentiation of Non-Hematologic Diseases Presenting with Diffuse Splenic Fluorodeoxyglucose Uptake Based on Bone Marrow and Lymph Node Accumulation Patterns

Abstract The goal is to assess whether bone marrow (BM) and lymph node (LN) uptake patterns can explain diffuse splenic uptake in non-hematologic conditions. Among 219 patients with high splenic uptake detected on 18F-FDG positron emission tomography/computed tomography between J...

A novel SUR1‐TMD0 interaction region contributes to glucose‐dependent inhibition of pancreatic K ATP channels by bupropion

Background and Purpose Pancreatic β‐cell ATP‐sensitive potassium (K ATP ) channels play a central role in glucose homeostasis by coupling cellular metabolism to insulin secretion. Although conventional K ATP channel inhibitors are effective insulin secretagogues, their clinical u...

Safety and Effectiveness of Inebilizumab in Patients with Neuromyelitis Optica Spectrum Disorder: Interim Analysis of a Post-marketing Surveillance in Japan

Inebilizumab is used in Japan for relapse prevention in aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Nationwide post-marketing surveillance (PMS) is underway to evaluate the real-world safety and effectiveness of inebilizumab in Japanese pa...

A needle-mounted guide for improving needle visualization during ultrasound-guided needle insertion: a simulation study in novice operators

Abstract Background In ultrasound-guided needle insertion, continuous needle visualization is crucial for accurate needle placement, particularly for beginners. Novice operators may have difficulty maintaining the spatial relationship between the needle trajectory and the ultraso...

Predictors of 12-Week Anamorelin Treatment Continuation in Gastrointestinal Cancer Cachexia: A Single-Center, Retrospective Study

Although anamorelin improves appetite and body composition in cancer cachexia, early discontinuation is common. We aimed to evaluate predictors of 12-week treatment completion and longitudinal changes among patients who completed treatment. This single-center, retrospective study...

Immune Absence as a Proposed Framework for Delayed Relapse After Curative-Intent Treatment in Human Papillomavirus-Associated Cervical Cancer

Delayed relapse after curative-intent treatment remains difficult to explain and predict in human papillomavirus (HPV)-associated cervical cancer, including after periods of sustained remission with undetectable circulating tumor DNA (ctDNA) or circulating HPV DNA. This limitatio...