Fujian Provincial Cancer Hospital

MRI-Based Radiomics Model for Pretreatment Prediction of Pathological Lymph Node Metastasis in Neuroendocrine Carcinoma of the Cervix: Dual-Center Development and External Validation

Objectives: To develop and externally validate MRI-based radiomics and clinicoradiomics models for predicting pathological lymph node metastasis (LNM) in neuroendocrine carcinoma of the cervix (NECC). Methods: This retrospective two-center study included 133 patients who underwen...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Integrated multi-omic analysis characterizes an IFNγ-responsive-to-myeloid-suppressive immune continuum in immune-active hepatocellular carcinoma

Immune-active hepatocellular carcinoma (HCC) is commonly treated as a single inflamed phenotype, although its internal immune heterogeneity remains incompletely defined. We integrated public bulk transcriptomic, single-cell, spatial transcriptomic, proteomic, phosphoproteomic, an...

Stress-resolved longitudinal single-cell and spatial transcriptomic analysis supports a tumor–immune remodeling framework during chemoradiotherapy in cervical cancer

Concurrent chemoradiotherapy (CRT) is standard for locally advanced cervical cancer, but early links between tumor adaptation and immune dysfunction remain incompletely resolved. We conducted an exploratory secondary analysis of public longitudinal single-cell RNA-sequencing data...

Prognostic association of postoperative pre-radiotherapy neutrophil-to-lymphocyte ratio with disease-free survival in oral squamous cell carcinoma patients undergoing adjuvant volumetric modulated arc therapy: an exploratory analysis

The prognostic value of postoperative pre-radiotherapy neutrophil-to-lymphocyte ratio (NLR) in oral squamous cell carcinoma (OSCC) patients receiving adjuvant volumetric modulated arc therapy (VMAT) remains inadequately characterized. This study evaluated the association of NLR w...

Patterns of survival and recurrence in non-pathological complete response to neoadjuvant immunochemotherapy for esophageal squamous cell carcinoma: a real-world single-center study

Neoadjuvant immunochemotherapy (NICT) is a strategy for locally advanced esophageal squamous cell carcinoma (ESCC), yet responses vary. Survival and recurrence patterns in non-pathological complete response (non-pCR) patients remain incompletely defined. This single-center retros...

Systemic artery-to-pulmonary artery fistulas and recurrence of noncancer-related hemoptysis after bronchial artery embolization: a retrospective study

To investigate the clinical and angiographic characteristics of systemic artery-to-pulmonary artery fistulas (SA-PAFs) in patients with noncancer-related hemoptysis undergoing bronchial artery embolization (BAE), and to assess their associations with procedural outcomes and recur...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

An ENE-related transcriptomic signature predicts distant metastasis risk and immune microenvironment features in nasopharyngeal carcinoma

Extracapsular nodal extension (ENE) is an adverse prognostic factor in nasopharyngeal carcinoma (NPC). In this study, we analyzed RNA-seq data from 159 NPC patients stratified by ENE status, identified differentially expressed genes, and developed an eight-gene machine-learning s...

Gut Microbiota-Derived Indole-3-propionic Acid Attenuates Titanium Dioxide Nanoparticle-Induced Liver Injury by Targeting Kupffer Cells via the Gut–Liver Axis

Abstract Nanotitanium dioxide (nTiO2) is widely used as a food additive, leading to chronic dietary exposure and rising health concerns. Although adverse effects on the liver and gut microbiota have been individually investigated, whether gut microbiota mediates nTiO2-induced liv...

Multi-omics profiling reveals PIK3CA -driven immunometabolic reprogramming in cervical cancer

The PIK3CA mutation is a prevalent driver in cervical cancer, but its role in orchestrating a coordinated remodeling of transcriptional, translational, and metabolic networks is poorly understood. We introduced the PIK3CA-E545K mutation into cervical cancer U14 cells via CRISPR/C...

Psychiatric disorders and gynecologic tumors

Previous epidemiological evidence has suggested associations between psychiatric disorders and gynecologic tumors, but the causal relationships have not been fully characterized. This study aims to investigate the potential causal relationships using genetic instrumental variable...

Green Light‐Driven, Diastereoselective Synthesis of Pentasubstituted α ‐Trifluoromethylated Pyrrolidines via a Singlet Carbene Process

Comprehensive Summary Trifluoromethylated heterocycles represent privileged structural motifs in pharmaceuticals and agrochemicals, as the incorporation of a CF 3 group significantly enhances metabolic stability, lipophilicity, and bioactivity. Among these, α ‐trifluoromethyl pyr...

Prognostic impact of supraclavicular lymph node metastasis in thoracic oesophageal squamous cell carcinoma in a large retrospective study

The definitions of regional nodes differ between the 12th edition of the JES and the UICC staging systems, and the most prominent difference is in the status of the supraclavicular lymph nodes (SCLN). This study was designed to investigate the prognostic impact of metastasis to S...

In vivo and FACS-based CRISPR/Cas9 screening uncovers VENTX as a crucial element in maintaining seminoma stemness

Seminoma, which is the most frequent testicular germ cell tumor, has stem cell-like features related to treatment resistance and recurrence, yet the molecular mechanisms that preserve its stemness are not well understood. This study aimed to discover the tumorigenesis and stemnes...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Subdivision of metachronous metastatic nasopharyngeal carcinoma based on the framework of TNM-9: A recursive partitioning analysis of real-world data

Abstract Purpose: To validate the prognostic value of the M1 category in version nine of the AJCC/UICC TNM staging system (TNM-9) in metachronous metastatic nasopharyngeal carcinoma (mmNPC) and to develop a refined M1 classification for improved risk stratification. Methods: Pati...

P1.164. Clinical Outcomes of Esophageal Bypass Surgery in Patients With Advanced Esophageal Cancer: A Single-Center Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Esophageal bypass surgery is a therapeutic approach for patients with unresectable esophageal cancer who cannot eat orally due to esophageal stricture. It is particularly indicated fo...

P1.165. Low Preoperative Fat-Free Mass Index Predicts Anastomotic Leakage and Poor Survival in Esophageal Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer is one of the most common gastrointestinal malignancies worldwide. In China, most patients are diagnosed at intermediate and advanced stages, and the treatm...

Multimodal fusion of radiomics, dosiomics and deep learning for predicting radiation-induced hypothyroidism after radiotherapy in nasopharyngeal carcinoma: a multicenter study

To develop and externally validate a prediction framework integrating clinical factors, dose‒volume histogram (DVH) parameters, radiomics, dosiomics and deep - learning (DL) features for individualised radiation-induced hypothyroidism (RIHT) risk assessment. This retrospective mu...