Frederiksberg Hospital

Personal Income Progression of Informal Family Caregivers of Children and Young Adults With Mental Disorders

Informal family care for a child with a mental disorder may negatively impact work capacity and decrease income. We compare prolonged sex-specific personal income progression between informal family caregivers of children/young adults with and without mental disorders. We evaluat...

Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study

Background/Objectives: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. Methods: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who comm...

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2...

ORTHOPAEDIC TRAUMA IN NORTHERN MALAWI'S CENTRAL HOSPITAL: INJURY PATTERNS, OPERATIVE NEED, AND SERVICE CONSTRAINTS

Malawi has a high burden of traumatic injury but limited orthopaedic surgical capacity, particularly in the northern region where a single orthopaedic surgeon serves a population of over four million. This study aimed to describe the epidemiology of orthopaedic trauma in northern...

Postoperative Delirium and the Association to Continuously Monitored Severe Deviations of Vital Signs at the General Ward After Major Abdominal Surgery

ABSTRACT Background Delirium is the most frequent neurological complication after surgery and is associated with increased postoperative morbidity and mortality. The underlying pathophysiology is not fully understood, but is suggested to be multifactorial, including hypoperfusion...

Intraglandular treatment with adipose-derived mesenchymal stem cells in patients with xerostomia due to Sjögren’s disease—a study protocol for aphase 1, triple-blinded, randomized, clinical trial

Xerostomia (the subjective feeling of dry mouth) is a prominent symptom in Sjögren’s disease and often related to hyposalivation. Xerostomia and hyposalivation negatively affect the oral health and have a significant negative impact on general health and overall quality of life....

The SocMed Database: coverage and clinical characteristics of individuals seen in social medicine in the capital region of Denmark

This study aimed to describe The SocMed Database, its content, completeness, and representativeness compared with the Danish National Patient Register (DNPR), alongside population characteristics within a biopsychosocial framework. In Denmark, Departments of Social Medicine manag...

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

ABSTRACT Aggregation of α‐synuclein (αSyn) is a hallmark of Parkinson's disease, yet its pathological roles remain poorly understood. Elucidating these roles requires detailed knowledge of the free energy landscape of αSyn self‐assembly, i.e. the states that can be populated and...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

Long-term Mortality and Shock-rate in Patients Surviving Out-of-Hospital Cardiac Arrest with and without early implantation of an Implantable Cardioverter Defibrillator

Introduction In patients who survive out-of-hospital cardiac arrest (OHCA), guidelines for implantation of an implantable cardioverter-defibrillator (ICD) are not unequivocal.Methods Patients resuscitated from OHCA of cardiac cause, without a reversible cause and an expected surv...

How can we succeed with integrated treatment for young people with co-occurring mental illness and substance use problems? Perspectives from young service users and carers

Purpose This study aims to explore young service users’ and carers’ experiences of dual diagnosis treatment, and their perceptions of the changes brought about by the implementation of integrated treatment in mental health services throughout Denmark. It also aims to explore whic...

Association of major depression with return to work and changes in employment rate across sociodemographic municipality characteristics: A register-based cohort study

AIMS: We examined whether the association between depression and return to work (RTW) varied by municipality characteristics. METHODS: In this nationwide register-based cohort study (2012-2018), adults aged 25-55 years with a first-time in- or outpatient contact for depression we...

ABCB1 Frameshift Deletion in Skye Terriers With Potential Pharmacogenetic Relevance

Ivermectin-associated neurotoxicity is a potentially life-threatening condition caused by disruption of the ABCB1 encoded P-glycoprotein drug transporter in certain dog breeds. Skye terriers are considered at increased risk of ivermectin toxicity despite the absence of an identif...

Childhood body mass index trajectories and subtypes of endometrial cancer: A Danish cohort study

Background Obesity in adulthood is a well-established risk factor for endometrial cancer, a heterogeneous disease comprising several histological subtypes. Although childhood body mass index (BMI) is linked to endometrial cancer, the role of childhood growth patterns in different...

Scalable clinical proteomics from DNA/RNA extraction flowthroughs enables integrated proteogenomic profiling from a single cancer biopsy

Abstract Background Precision oncology has largely relied on genomic and transcriptomic sequencing to guide therapy selection in patients with advanced cancer. However, these molecular layers do not fully capture the functional state of tumors, as proteins largely represent the a...

No group-level changes in corticospinal excitability following low-intensity theta-burst ultrasound stimulation of the primary motor hand area

Abstract Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique offering high spatial precision and depth penetrance. Theta burst TUS (tbTUS), featuring a temporal theta burst stimulation pattern, has been reported to facilitat...

Use of Attention Deficit Hyperactivity Disorder Medication Among Danish Children and Adolescents From 2010 to 2023

Introduction: Pharmacological treatment is an important component in the multimodal management of attention deficit hyperactivity disorder (ADHD), but contemporary trends in ADHD medication use among boys and girls in Denmark have not been fully characterized. This study aimed to...

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

AIMS: Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, c...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...