Florida College

Functional trait space overlaps reveal ecological resilience of bird communities in Atlantic Forest fragments

While fragmentation is known to affect species diversity, the degree to which functional structure is retained relative to primary forests and the factors driving this retention remain poorly understood. Here, we applied the concept of ecological resilience to forest fragmentatio...

CerS2-mediated lipotoxicity and calcium signaling: a novel sequential mechanism of apoptosis in cancer

Abstract The classical paradigm of the sphingolipid rheostat—balancing pro-apoptotic ceramide against pro-survival sphingosine-1-phosphate—has evolved into a complex signaling landscape where N-acyl chain length serves as the fundamental determinant of biological outcomes. This p...

Functional seizures: care experiences of U.S. Veterans and their care partners

Functional seizures (FS) present substantial diagnostic and treatment challenges, particularly for Veterans with multiple medical and psychiatric comorbidities including post traumatic stress disorder, mood disorders and traumatic brain injury. To more effectively care for Vetera...

Evaluation of Antiviral Drugs’ Central Nervous System Distribution Using In Vitro Blood–Brain and Blood-CSF Barrier Models: The Impact of Serum Protein Concentration

The blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB) are dynamic neurovascular interfaces that maintain central nervous system (CNS) homeostasis by tightly regulating paracellular and transcellular molecular transport. Intercellular communication between ad...

Supplementation with Bacillus -based direct-fed microbials for developing beef heifers: impacts on fecal and vaginal microbiome, growth, and reproductive performance

Abstract This 2-year study evaluated the effects of Bacillus-based direct-fed microbial (DFM) supplementation on fecal and vaginal microbiomes, growth, and reproduction of beef heifers. On day 0 (30 days after weaning), Brangus crossbred beef heifers (n = 64 per year) were strati...

COFFlow: Building-Block-Based Generative Modeling for Two-Dimensional Covalent Organic Framework Discovery

Abstract Two-dimensional covalent organic frameworks (2D COFs) are promising porous materials with vast yet largely unexplored design space arising from diverse building blocks (BBs) and crystal topologies. Efficient crystal structure prediction (CSP) and inverse design of 2D COF...

Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering

BACKGROUND: Current necrotizing enterocolitis (NEC) diagnostic criteria fail to capture the full spectrum of intestinal injury. We aimed to identify diagnosis-independent clinical patterns of intestinal injury among vulnerable very low birth weight (VLBW) infants using unsupervis...

Structural insight into the activation of adenosine A2AR/A2BR by the dual-agonist MRS3997

Abstract A 1 R, A 2A R, A 2B R, and A 3 R adenosine receptors comprise a G protein-coupled receptor (GPCR) subfamily that regulates many bodily processes. Subtype-selective agonists potentially treat inflammatory and ischemic conditions. The dual A 2A R/A 2B R agonist MRS3997 pro...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures

OBJECTIVES: To compare fracture related infection (FRI) rates and outcomes between ceftriaxone (CTX) and cefazolin plus gentamicin (C+G) for antibiotic prophylaxis in Gustilo-Anderson (GA) type III open lower extremity fractures. METHODS: Design: Retrospective cohort study. SETTI...

Global burden of moyamoya syndrome in pediatric sickle cell disease and implications for the neurosurgical workforce: a systematic review

Abstract Objective The aims of the study were twofold: 1) quantify the global burden of pSCD|MMS, and 2) estimate the number of children who warrant specialist evaluation for possible surgical revascularization. Methods A systematic review was conducted following PRISMA guideline...

IBI-DT as a complementary framework for prioritizing candidate genes, interactions, and pathways in congenital heart disease

Congenital heart disease (CHD) has a complex and heterogeneous genetic architecture. Conventional population-level association analyses can identify average genetic effects across a cohort but may miss subgroup-specific, individualized, and interaction-related signals. To address...

Comparative evaluation of 16S rRNA sequencing strategies reveals superior resolution of the healthy Korean salivary microbiome by full-length sequencing

Although next-generation sequencing has elucidated complex microbial networks within the human oral cavity, current analyses remain predominantly limited to genus-level resolution, and most of the human oral microbiome landscape is based on Western population datasets. Because th...

Frequent Use of Restricted Oral Intake During Hospitalization for IBD Flares Was Not Associated with Improved Clinical Outcomes: A Multicenter Retrospective Cohort Study

There are limited indications for bowel rest in hospitalized patients with inflammatory bowel disease (IBD) flares, particularly in patients with only inflammatory disease (i.e., no obstruction, abscess, or fistula). We aimed to assess the frequency of restricted oral intake and...

Structural Control of Phthalate Toxicity in Agricultural Soil Biofilms: Aliphatic-Chain-Length-Driven Hazards Revealed by Field Evidence, Multiomics, and Quantum Chemical Analysis

Abstract Phthalates (PAEs) pose significant ecological risks in greenhouse soils because of their hydrophobicity and persistence. This study combined field survey, microcosm experiments, multiomics analysis profiling, and quantum chemical calculations to investigate how the aliph...

KRstereo: Predicting β-Hydroxy Stereochemistry in Polyketides Using Protein Language Models

Abstract Polyketides are a major class of bioactive natural products whose activities are often determined by the stereochemistry of β-hydroxyl groups. In type I polyketide synthases (PKSs), ketoreductase (KR) domains establish these stereocenters, making accurate prediction of K...

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil ‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all...

Score Reliability and Validity of a Mexican Dialect Spanish Translation of the Flourishing Scale With Mexican Earthquake Survivors

ABSTRACT The Flourishing Scale (FS) scores have demonstrated acceptable psychometric properties in general adult populations, but no previous research has validated its use among natural disaster survivors. This study examined the reliability, validity, and measurement invariance...

Role of Ion Channels in the Pathophysiology of SARS-CoV-2

In the pathophysiology of SARS-CoV-2, the critical role of ion channels has become increasingly evident during the COVID-19 crisis. This review offers a comprehensive analysis of the functions of ion channels, including viroporins, in both the viral life cycle and the host immune...

Four coding-complete genomes of bovine viral diarrhea virus-2a ( Orthopestivirus tauri genotype a) isolated from farmed white-tailed deer ( Odocoileus virginianus ) in Florida, USA, in 2018

To date, no bovine viral diarrhea virus-2 (BVDV-2) coding-complete genomes are available from white-tailed deer (WTD) in Florida. We determined the coding-complete genome sequences of four BVDV-2 isolates from farmed WTD that were found dead in 2018. These belonged to BVDV-2 sub-...