First People's Hospital of Chongqing

Cross‐cultural adaptation and initial evaluation of selected measurement properties of the simplified chinese version of the knee injury and osteoarthritis outcome score joint replacement in patients with knee osteoarthritis

Abstract Purpose This study aimed to translate and culturally adapt the knee injury and osteoarthritis outcome score joint replacement (KOOS‐JR) into simplified Chinese and provide an initial evaluation of selected measurement properties in patients with knee osteoarthritis (OA)...

Hydrogen-Associated CXCL2 Drives Adaptive Inflammatory-to-Proliferative State Transition during Skin Wound Healing

Abstract Background Wound healing is an environmentally adaptive process. It requires a tightly coordinated transition from an inflammatory to a proliferative state, which occurs in response to oxidative and inflammatory stress. Molecular hydrogen (H2) is a widely recognized medi...

Single-cell atlas reveals ZBP1-driven inflammatory circuits in the nasal mucosa of allergic rhinitis

Allergic Rhinitis (AR) is driven by persistent mucosal inflammation and immune imbalance. The identification of susceptibility factors, particularly genes regulating mucosal immunity, contributes to the precision treatment of AR. We performed single-cell RNA sequencing (scRNA-seq...

Cross-national patterns of cardiometabolic disease progression from healthy state to stroke: a cause-specific Cox transition analysis of six international cohorts

Cardiometabolic disease progression to stroke involves intermediate transitions through hypertension (HTN) and diabetes (DM). However, cross-national comparisons of these transition patterns remain unexplored. We compared cardiometabolic progression pathways, including death as a...

Isoliquiritigenin Triggers HMOX1-Driven Ferroptosis to Suppress Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death, and new treatment strategies are needed. Ferroptosis is an iron-dependent cell death driven by lipid peroxidation, and targeting ferroptosis has become a new strategy for anti-NSCLC. Isoliquirit...

Proximity of anterior mediastinal tumors to the left innominate vein as a predictor of surgical difficulty in subxiphoid VATS: a retrospective analysis

Subxiphoid video-assisted thoracoscopic surgery (SVATS) is widely used for anterior mediastinal tumor resection, yet proximity to major vessels creates technical challenges. This study quantifies how the vertical distance between the tumor and the left innominate vein (LIV) predi...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Can New Energy Demonstration City policy improve ESG disclosure quality? Mechanism identification from the perspective of inhibiting corporate greenwashing

Against the backdrop of the advancing "dual carbon" strategy and the global emphasis on sustainable development, ESG disclosure has become a critical dimension of corporate governance. However, the proliferation of ESG controversies, particularly corporate "greenwashing," has cha...

National Epidemiological Trends in Hepatitis A–E Serologic and Virologic Markers in the United States, 2011–2023: A Population-Based Study

Viral hepatitis caused by A to E imposes a substantial global burden of liver disease. Despite US control strategies, long-term national data covering serologic markers of all five hepatitis viruses remain limited. In this study, we analyzed epidemiologic trends from 2011 to 2023...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

Inflammation-associated hsa_circ_0054391 regulates epithelial-mesenchymal transition and vasculogenic mimicry in colorectal cancer via the miR-1252-3p/VEGFA/ZEB1 axis

Abstract To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls ( n =...

Post-Competitive Interface Reprogramming for Amplified Multiplex Bacterial Fingerprinting in Biofluids

Abstract Low-burden bacterial infections demand rapid and reliable pathogen fingerprinting, yet cross-reactive sensor arrays remain limited by weak and overlapping optical signatures. Here we introduce postcompetitive interface reprogramming (PCIR), a sensor-array strategy that e...

The pregnancy vaginal microbiota exhibits alterations in association with gravidity, parity, and miscarriage history: a cohort study

Vaginal microbiota plays a critical role in reproductive health, yet the impact of woman’s obstetric history including gravidity, parity and miscarriage history, remains inadequately characterized. We conducted a cohort study to identify microbial biomarkers linked to these facto...

Mechanistic insights into VSIR-mediated AXL regulation and gastric cancer proliferation

Gastric cancer (GC) progression is frequently driven by complex tumor microenvironment signals. Here, our study identifies V-set immunoregulatory receptor (VSIR) as a key driver of GC progression via AXL regulation. High-throughput RNA sequencing demonstrated that VSIR overexpres...

Evaluating potential risk factors linked to endometriosis

Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association between 108 traits and EMT by means of Mendelian randomizati...

Towards differentiated governance: A typology and differentiated governance framework for county-level traditional Chinese medicine hospitals in China

Public county-level Traditional Chinese Medicine (TCM) hospitals are critical for integrating traditional and modern medicine, yet their heterogeneous development potential hinders policy implementation. Using Zhejiang Province as a case and an integrated Resource Dependence-Comp...

Clinical Relevance and Regulatory Mechanisms of LINC01521 in Papillary Thyroid Carcinoma

ABSTRACT Objective Papillary thyroid carcinoma (PTC) is a well‐differentiated malignancy derived from thyroid follicular epithelial cells. This study explores the functional role and underlying mechanisms of LINC01521 in PTC, aiming to provide new strategies to improve prognostic...

Perioperative carbohydrate loading improves comfort without adverse metabolic or neonatal effects in gestational diabetes mellitus

Preoperative carbohydrate loading has been known to overcome discomfort and complications associated with cesarean section, but there is a scarcity of evidence on its safety and benefits in patients with gestational diabetes mellitus (GDM). In this study, pregnant women with norm...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Gender-Role Identity as Moderators Between Class Environment and Aggressive Behaviors Among Chinese Children

School violence is a major global public health issue that has received increased scrutiny in recent times. Prior studies have indicated that variations in aggressive behaviors among students are associated with factors such as gender-role identity and class atmosphere. However,...