First People's Hospital of Chongqing

Deep learning-powered virtual eosin-based elastic fiber framework imaging improves objective grading and prognostic stratification of lung adenocarcinoma

Histological grading of lung adenocarcinoma is limited by interobserver variability, particularly when distinguishing noninvasive lepidic growth from invasive patterns. This distinction depends on evaluation of the alveolar elastic fiber framework, which is often insufficiently v...

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

Abstract Purpose The radiation‐induced bystander effect (RIBE) refers to biological responses in non‐irradiated cells exposed to signals from irradiated cells and may contribute to tumor control during radiotherapy. Periodic dose heterogeneity caused by the thread effect of helic...

A Multimodal large language model-based triage tool for osteoporotic vertebral compression fractures using posture and movement videos

Osteoporotic vertebral compression fracture (OVCF) is common yet frequently underdiagnosed due to nonspecific symptoms and limited access to definitive imaging. We developed a two-stage screening framework that integrates prompt-guided multimodal large language model (LLM) featur...

SERPINC1-mediated hereditary antithrombin deficiency with refractory pulmonary embolism: successful treatment with VA-ECMO and interventional thrombus aspiration

Venous thromboembolism (VTE) carries substantial global morbidity and mortality, with 50%–60% of disease variability attributed to genetic factors. Hereditary antithrombin deficiency (HATD), caused by pathogenic variants in the SERPINC1 gene, is an autosomal dominant thrombophili...

Pregnancy loss and prevalent cardiometabolic multimorbidity: a two-stage individual participant data analysis of CHARLS, ELSA, and HRS

Cardiovascular disease remains the leading cause of death worldwide, and cardiometabolic multimorbidity (CMM) is associated with substantially higher mortality and reduced life expectancy. Pregnancy loss is common and has been linked to later cardiovascular risk, but multinationa...

Integrative analysis of network pharmacology and machine learning suggests potential anti-colorectal cancer mechanisms of Taohong-Siwu decoction

Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide, characterized by high morbidity and poor prognosis. Although traditional Chinese herbal formulas have shown promising therapeutic potential, their multi-target mechanisms in CRC are still poorly und...