First Hospital of Shanxi Medical University

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

Hyaluronic Acid Microneedle With α‐Boswellic Acid Heal Oral Ulcers by Anti‐inflammatory Activity

OBJECTIVE: Conventional topical therapies for oral ulcers remain limited due to poor mucosal adhesion and rapid clearance by saliva. To overcome these challenges, we aimed to develop a microneedle patch with α-boswellic acid for targeted anti-inflammatory treatment of oral ulcers...

The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention

INTRODUCTION: Early-onset schizophrenia (EOS) is a severe psychiatric disorder with poor long-term outcomes. It offers a unique opportunity to examine the neurobiological mechanisms of schizophrenia without the confounding effects of adult environmental factors. Oxytocin (OXT), a...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Transillumination improves lymph node yield in left-sided colorectal cancer: an ambispective cohort study

Accurate lymph node (LN) staging is essential for prognosis and treatment decisions in colorectal cancer (CRC). Existing methods to assist LN retrieval, such as fat-clearing and methylene blue staining, improve yield but are complex, time-consuming, and require additional reagent...

FAM45A-Mediated Persistent Memory-Like Fibroblast Reprogramming Drives PM2.5-Exacerbated Allergic Asthma

Abstract Chronic coexposure to fine particulate matter (PM2.5) and house dust mite (HDM) allergen worsens allergic asthma outcomes, yet the stromal cell mechanisms linking combined environmental and allergic risk factors remain incompletely defined. Airway fibroblasts are traditi...

OMA1-Mediated Mitochondrial Stress Exacerbates PANoptosis in Macrophages Via the mtROS-ZBP1 Axis in Coal Dust-Exposed Asthma

This study aimed to elucidate the mechanisms by which coal dust exposure (CDE) exacerbates asthma, focusing on macrophage mitochondrial dysfunction and programmed cell death, and identifying the key regulatory molecules involved. Control, CDE, Asth, and CDE+Asth mouse models were...

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

BACKGROUND: This study aims to achieve accurate prediction of high-risk molecular subtypes of gliomas through a cross-scale Combined model, matching the model's classification metrics with patient risk stratification and exploring the underlying biological mechanisms. METHODS: Th...

Candidate plasma proteins associated with all-cause mortality among patients with prostate cancer: a UK biobank analysis

Evidence remains limited regarding circulating protein signals associated with long-term mortality among patients with prostate cancer (PCa). This study aimed to identify circulating proteins associated with long-term mortality in PCa patients and assess their potential increment...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Prevalence and risk factors of human papillomavirus infection and cervical cytological lesions among women in Shanxi, China: a cross-sectional study

Abstract Background With the introduction of human papillomavirus (HPV) vaccination into China’s national immunization programme in November 2025, robust baseline evidence on HPV epidemiology is critical. Data on HPV prevalence, genotype-specific distribution, risk factors, and t...

18F-FDG PET/CT in idiopathic retroperitoneal fibrosis with predominant presacral involvement

Idiopathic retroperitoneal fibrosis (IRF) is a rare fibro-inflammatory disease that is often diagnosed only after the development of complications, making early recognition and long-term management challenging. 18 F-FDG PET/CT provides both anatomical and functional information,...

18F-PSMA-1007 PET/CT in PSMA-avid bladder urothelial carcinoma with extensive bone metastases: a case report

Abstract Background: PSMA PET can accurately localize PSMA-expressing lesions. However, PSMA expression is not limited to prostate cancer cells but is also widely present in the neovascular endothelial cells of various solid tumors. Case presentation: We present a case of urothel...

Surface Modification of Sulfonated Carbon Fiber-Reinforced Polyetheretherketone Composite by Polydopamine-Assisted nHA/Zn/CMCS and Its Evaluation of Osteogenic Properties

OBJECTIVE: Carbon fiber-reinforced polyetheretherketone (CF/PEEK) possesses the elastic modulus similar to that of natural bone, yet its inherent surface hydrophobicity and bio-inertness restrict its application in oral implantation. To overcome this limitation, this study propos...

Decision fusion model for predicting WHO/ISUP grade of clear cell renal cell carcinoma based on multi-phase CT radiomics: a multicenter study

The pathological grading of clear cell renal cell carcinoma (ccRCC) plays a critical role in both its diagnosis and treatment. This study aimed to develop a decision fusion model based on multi-phase CT to predict the WHO/ISUP grade of ccRCC. This retrospective study included cli...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Association Between the Non-High-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio and Sarcopenia in Older Chinese Men.

=0.164）. Conclusions NHHR is inversely associated with sarcopenia risk among older Chinese men，while this association is substantially attenuated after adjustment for BMI，suggesting it may be largely confounded by body size or obesity-related factors.These findings should be i...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...