First Hospital of Shanxi Medical University

The SIRT1-ΔExon8 transcript is differentially expressed across brain regions and during neural stem cell differentiation in rats

SIRT1 is an NAD+-dependent deacetylase involved in the maintenance and differentiation of neural stem cells (NSCs). Although alternative splicing increases the regulatory complexity of SIRT1, its splice isoforms in the rat nervous system remain poorly defined. This study aimed to...

Toward therapnostic integration as a new paradigm for precision management of interstitial cystitis driven by medical-engineering convergence

Abstract Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a complex chronic inflammatory disease involving mucosal barrier defects, neurogenic inflammation, mast cell activation, and tissue remodeling. Current diagnosis lacks objective biomarkers, relying instead on sympto...

Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker Cohorts

Objective: To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts. Methods: We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and exter...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...