First Hospital of Lanzhou University

Systematic review and network meta-analysis of performance of the Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR/EULAR APS classification criteria for patients with antiphospholipid syndrome: A protocol

Background Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent thrombotic events and/or adverse pregnancy outcomes. Although three classification criteria—the 1999 Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR/EULAR antiphospholipid s...

Histological significance of MPO, ER, and PR in endometrial polyps of premenopausal women.

BACKGROUND: Endometrial polyps (EP) can lead to irregular bleeding and infertility in women. The identification of biomarkers associated with EP holds clinical importance. METHODS: Patients who visited the hospital due to abnormal uterine bleeding, endometrial thickening, abnorma...

Explainable machine learning model based on cardiac CT angiography for predicting functional improvement after atrial fibrillation ablation: a multicenter study

Radiofrequency ablation is an established therapy for atrial fibrillation (AF), but outcomes are heterogeneous in patients with concomitant heart failure (HF). Therefore, we aimed to develop an explainable machine learning (ML) model based on cardiac CT angiography (CTA) for pred...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

Cancer heterogeneity drives therapeutic failure, resistance, and relapse and encompasses variation across genetic, cellular, tissue, organ, and systemic scales. Existing frameworks define malignant capabilities and tumor–microenvironment interactions but less explicitly address h...

Rethinking ovarian cancer early detection: risk-adapted strategies, diagnostic pathways, and emerging biomarkers

Ovarian cancer early detection remains a major challenge because most patients present with advanced disease, whereas population-wide screening in average-risk women has not shown a clear mortality benefit. This narrative review examines how early detection should be redefined in...

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Abstract PAXX is a DNA double-strand break repair factor involved in classical non-homologous end joining. Although elevated PAXX expression has been reported in colon cancer, its functional role and downstream mechanisms in colorectal cancer (CRC) remain incompletely defined. Th...

Investigation of the transcription factor TEAD-based material basis of Astragalus synergistic dacarbazine in the treatment of uveal melanoma

Abstract Uveal melanoma (UM) is the most common intraocular malignancy in adults, and despite great advances in combination drug therapies based on UM-related pathways, targeted therapies remain an unmet medical need, and there has been a decrease in sensitivity to chemotherapy....

Human Umbilical Cord Mesenchymal Stem Cells Enhance Folliculogenesis and Fertility in Premature Ovarian Failure Mice via Regulating Steroid synthesis

Abstract Background Premature Ovarian Failure (POF) is a dysfunction that severely impacts women's physiological health and reproductive function. Human umbilical cord mesenchymal stem cell (hUCMSC) transplantation offers a promising therapeutic option for restoring ovarian funct...

Perioperative esketamine-containing strategies and postoperative neurocognitive outcomes in older surgical patients: a systematic review and meta-analysis of randomized controlled trials with certainty assessment

Postoperative delirium (POD) is a common neurocognitive complication after surgery in older adults and is associated with adverse clinical outcomes. Esketamine, the S-enantiomer of ketamine and an N-methyl-D-aspartate (NMDA) receptor antagonist with established analgesic effects...

Multilevel structural covariance network alterations of thalamo-cortical circuit in liver cirrhosis patients without overt hepatic encephalopathy: associations with liver function and imaging transcriptomics

To better understand the alterations of thalamo–cortical circuit in liver cirrhosis without overt hepatic encephalopathy (LC-nOHE) patients, we constructed and analyzed structural covariance network (SCN) and explored the relationship of these alterations with liver function and...

Global Trends in Heart Failure Self-Care Research: A Bibliometric and Visual Analysis

Background: Adequate patient self-care is fundamental to effective heart failure (HF) management and is endorsed by international guidelines to improve clinical outcomes. Despite a growing body of evidence, the global research landscape, including publication trends, collaborativ...

Beyond the Clock: Reprogramming Fertility in Diminished Ovarian Reserve

Diminished Ovarian Reserve (DOR) is a significant manifestation of female reproductive aging that profoundly impacts fertility and quality of life. In recent years, the emergence of aging reprogramming technologies has provided new insights into the mechanisms underlying DOR and...

Machine Learning–Based Cytokine Endotyping of Thyroid Eye Disease

Purpose: Thyroid eye disease (TED) exhibits profound phenotypic heterogeneity that conventional binary thyrotropin receptor antibody fails to capture. We aimed to deconstruct this heterogeneity by establishing a cytokine-derived molecular taxonomy. Methods: We profiled 102 plasma...

Optimal timing of endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: a multicenter retrospective analysis

To compare the clinical outcomes of ERCP combined with laparoscopic LC using both one-step and two-step approaches for the treatment of cholecystocholedocholithiasis, and to investigate the optimal timing for performing LC within two weeks after ERCP. The clinical data of 520 pat...

From overweight/obesity to metabolic syndrome: increased postoperative survival risk in gastric cancer

Overweight/obesity and metabolic syndrome (MetS) are recognized as potential risk factors for gastric cancer, but their impacts on postoperative morbidity and overall survival (OS) following radical gastrectomy remain controversial. We hypothesized that overweight/obesity and Met...

Clinical value of artificial intelligence ultrasound-assisted diagnostic system in the differential diagnosis of benign and malignant thyroid nodules

Accurately distinguishing the benign thyroid nodules (BTNs) and malignant thyroid nodules (MTNs) is crucial for treatment planning and prognosis. This study aims to explore the clinical value of artificial intelligence ultrasound-assisted diagnostic system (AI-UADS) in diagnosing...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study

Observational studies have shown that air pollution may affect functional outcome following ischemic stroke. Our study aimed to explore the relationship between genetically predicted specific air pollutants and poststroke functional outcomes using the Mendelian randomization (MR)...