First Hospital of Jilin University

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Developing an explainable machine-learning model for short-term identification of neonatal cholestasis in preterm infants: a retrospective matched case-control study

Neonatal cholestasis (NC) is an important hepatobiliary complication in preterm infants, but its short-term identification before the first clinical diagnosis remains challenging. We aimed to develop an explainable machine-learning model for short-term identification of NC using...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications

The orofacial system is constantly subjected to complex and dynamic mechanical forces and exhibits highly specialized mechanosensory and mechanoresponsive behaviors. However, current studies are mostly limited to single tissues or specific pathway analyses, which are insufficient...

Unraveling the protective effect of weekend catch-up sleep on overactive bladder risk

BACKGROUND: Weekend catch-up sleep (WCS) has emerged as a new research focus in the field of sleep. Earlier research has shown that sleep and overactive bladder (OAB) are closely related; however, the connection between WCS and OAB has yet to be reported. METHODS: Data from the 2...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Behçet disease with left superficial femoral artery pseudoaneurysm: a case report

Background: Behçet’s disease (BD) is a systemic vasculitis secondary to connective tissue disease of unknown etiology. The prevalence of BD varies geographically, being highest along the ancient Silk Road, including in the Middle East and East Asia. BD may involve the gastrointes...

Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes

OBJECTIVE: To examine the relationship between cognitively stimulating activities and cognitive function among older adults in residential care homes. METHODS: A convenience sampling method was used to recruit older adults from three residential care homes in East China. Data wer...

Transthoracic echocardiography as a predictor of spinal anesthesia-induced hypotension in cesarean section: a prospective observational study

Spinal anesthesia-induced hypotension (SAIH) is a common complication during cesarean delivery and is closely associated with maternal intravascular volume status. However, reliable real-time assessment of volume changes remains challenging. This study aimed to evaluate whether t...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Bioinspired MXene-BasedFlexible and Degradable Membranesfor High-Performance Electromagnetic Shielding

Abstract Wearable shielding electronic skin is highly desirable for protecting humans from electromagnetic radiation. However, conventional wearable electromagnetic interference (EMI) shielding materials still encounter major challenges in simultaneously achieving high shielding...