First Hospital of Jilin University

Aberrant lipid metabolic reprogramming accelerates gastric cancer malignancy through diminished ceramide-driven ALPP inhibition

Metabolic reprogramming is a canonical hallmark of cancer that reflects the biological properties of tumors. Deciphering the metabolic profiles and key metabolites involved in tumor progression is pivotal for advancing metabolism-centric precision oncology against gastric cancer...

PLEKHA5-targeted photothermal-gene combination therapy via mPDA@DMEA@siRNA nanoparticles suppresses melanoma progression

Melanoma is an aggressive skin malignancy characterized by high metastatic potential and resistance to current systemic therapies, highlighting the need for novel molecularly targeted and minimally invasive treatment strategies. Photothermal therapy enables localized tumor ablati...

IGFBP2 attenuates high glucose-induced endothelial dysfunction through PI3K/Akt/eNOS pathway activation

Endothelial dysfunction induced by hyperglycemia is a key event in diabetic vascular complications and is closely associated with impaired PI3K/Akt/eNOS signaling. Insulin-like growth factor-binding protein 2 (IGFBP2) has been implicated in metabolic regulation and cell survival,...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Nanoscale tire wear particles disrupt the blood–testis barrier and impair spermatogenesis through ROS–driven ferritinophagy and ferroptosis

Tire wear particles (TWPs) are a major source of micro- and nanoplastics. However, reports on nanoscale tire wear particles, especially regarding their potential hazards to the male reproductive system, remain scarce. Here, we examined whether nanoscale tire wear particles impair...

Cationic Amphiphilic Polypeptides With Immunogenic Cell Death Inducing Activity for Inhibition of Metastatic Bone Cancer

Immunogenic cell death (ICD)-mediated activation of antitumor immunity is being explored as a therapeutic approach for cancers with bone metastasis. In this study, several cationic amphiphilic polypeptides were obtained to investigate their architecture-dependent cytotoxicity and...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

ProtoSurv: prototype-guided adaptation of computed tomography foundation model for lung-cancer prognosis prediction

Abstract Prognosis prediction is important for precision treatment in lung cancer. Chest computed tomography (CT) and deep learning are feasible approaches for learning imaging-based prognostic representations. However, prognostic labels are difficult to obtain because survival e...

Characteristics of microplastic release from self-heating food packaging and its health risks to human population

While existing research on microplastics (MPs) migration has predominantly focused on microwave-heated plastic containers and short-term exposure within liquid media, the exposure characteristics and human health risks associated with the emerging scenario of self-heating foods r...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Sex-specific proteomic risk scores reveal distinct cardiovascular risk profiles and improve prediction of major adverse cardiovascular events in hypertension

Abstract Background Individuals with hypertension face a substantial residual risk of major adverse cardiovascular events (MACE), yet current clinical risk models often fail to capture the complex pathophysiological heterogeneity and sex differences within this population. This s...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Solitary necrotic nodule of the liver: a single-centre retrospective CEUS study of 87 lesions

To retrospectively characterise the sonographic features of solitary necrotic nodules of the liver (SNNL) on conventional ultrasound (US) and contrast‑enhanced ultrasound (CEUS), and to identify imaging features supporting differential diagnosis. Eighty‑one consecutive patients w...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

HSPA5 enhances the survival rate of human cells by protecting mesenchymal stem cells from heat stress

Xenotransplantation of human cells into pigs holds great promise for the development of humanized animal models, large-scale production of human cells, and regeneration of humanized organs. However, the low efficiency of human cell transplantation severely hampers its clinical tr...

Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer

Emerging evidence implicates insomnia as a potential risk factor in carcinogenesis, potentially involving systemic inflammation, circadian disruption, and microbiome alterations. However, the molecular associations linking insomnia-related features to colorectal cancer (CRC), par...

Lethal C57BL/6 mouse model for Yezo virus infection and antiviral therapeutic evaluation

Yezo virus (YEZV) is an emerging tick-borne orthonairovirus that causes febrile illness and hepatic injury in humans. However, its pathogenesis and effective antiviral interventions remain poorly characterized. In this study, we generated a lethal, mouse-adapted YEZV strain throu...

Early renal perfusion phenotypes and renal recovery in critically ill patients with or at risk for acute kidney injury: a prospective multicenter cohort study

BACKGROUND: Acute kidney injury (AKI) in critical illness is heterogeneous, and conventional Kidney Disease: Improving Global Outcomes (KDIGO) classification may not capture early physiologic differences relevant to renal recovery. METHODS: Critically ill adults with or at risk f...

Emerging perspectives and promising solutions: lactylation modification in chemo- and radiotherapy of cancer

Protein lactylation modification represents an emerging post-translational protein modification that regulates protein function through the covalent attachment of lactate to protein lysine residues, thereby linking epigenetic regulatory mechanisms to cellular metabolic activities...