First Affiliated Hospital of Zhengzhou University

Liquid biopsy: current applications and future directions

Abstract This review starts with the historical background and biological features to classify mainly the liquid biopsy biomarkers, such as circulating tumor DNA, circulating tumor cells, extracellular vesicles, non-coding RNAs, tumor-educated platelets and tumor-associated antig...

A hydrated HA/F127 biointerface for polyphenol release modulation and active–passive antibacterial protection on EGCG-loaded UHMWPE joint materials

Abstract Periprosthetic joint infection remains a major challenge for artificial joint materials, highlighting the need for antibacterial and anti-adhesive ultrahigh molecular weight polyethylene (UHMWPE) surfaces. Here, a hydrated hyaluronic acid (HA)/Pluronic F127 biointerface...

Mechanistic insights into ultraviolet-crosslinked sulfonated hyaluronic acid microspheres for stable biointerfaces on biodegradable cerebrovascular magnesium implants

Ischemic stroke remains a leading cause of death and disability worldwide, highlighting the urgent need to develop safer and more effective cerebrovascular implants. Biodegradable magnesium (Mg) alloys offer advantages such as high mechanical strength and the presence of neuropro...

A peroxidase-mimetic platinum nanocluster induces concurrent DNA damage and oxidative cleavage in paediatric glioblastoma cells

The impermeability of the blood–brain barrier (BBB), formed by a monolayer of endothelial cells, remains a major obstacle for delivering chemotherapeutic drugs to the brain. Ultra-small nanoparticles, particularly nanoclusters smaller than 2 nm, offer a promising strategy to over...

Primary Cardiac Angiosarcoma Initially Presenting with Sick Sinus Syndrome and Pericardial Effusion: A Case Report

Abstract Background Primary cardiac angiosarcoma is a rare and highly aggressive malignancy whose clinical presentation is primarily driven by local invasion and metastatic dissemination. Its rapid progression and frequent diagnostic delay contribute to a markedly poor prognosis....

An energy-difference indicator for improved quantification of bone mineral density using dual-energy CT

Accurate assessment of bone mineral density (BMD), particularly volumetric BMD (vBMD), is central to evaluating bone quality and monitoring bone regeneration. Although dual-energy computed tomography (DECT) combined with virtual monoenergetic imaging (VMI) enhances quantitative i...

Associations of health literacy and eHealth literacy with cyberchondria: a systematic review and meta-analysis

Abstract Background Health literacy and eHealth literacy are related but conceptually distinct constructs that may influence how individuals engage with online health information. However, observational studies have reported positive, negative, and null associations with cybercho...

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation

The PI3K/AKT signaling pathway serves as a pivotal regulatory hub that governs essential cellular processes, including growth, proliferation, metabolism, survival, and migration. In the context of tumorigenesis and cancer development, aberrant activation of this pathway drives ma...

Computational identification and experimental validation of shared diagnostic biomarkers and gene signatures across HLA-B27-associated immune-mediated diseases

HLA-B27 is strongly associated with a spectrum of immune-mediated diseases, including axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), inflammatory bowel disease (IBD), and acute anterior uveitis (AAU). However, the shared molecular mechanisms and cross-disease diagnos...

Differential nodal topology in resting-state networks as a potential imaging marker for adolescent bipolar and depressive disorders

Overlapping clinical features and the absence of objective diagnostic markers frequently lead to the misdiagnosis of adolescent bipolar disorder (BD) as major depressive disorder (MDD). However, direct comparisons of functional brain network topology between adolescents with MDD...

Reprogramming pulmonary B cells by ANXA1 silencing halts lung metastatic niche formation in breast cancer

Lung metastasis remains a determinant of poor prognosis and survival in breast cancer and is understood to depend on a permissive pulmonary immune niche rather than tumor cell traits alone. Here, we developed a host-directed RNA interference strategy to modulate this niche by rep...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Molecular subtyping of colorectal cancer based on aging-related gene network perturbation analysis and functional validation of MAP1B

Molecular heterogeneity of colorectal cancer (CRC) remains a major barrier to precision therapy. In this study, we integrated eight public aging-related resources to construct an aging-related gene set and performed network perturbation analysis on the TCGA CRC cohort using a Rea...

Lactylation-regulated METTL3-mediated cholesterol metabolic reprogramming via FDFT1 facilitates macrophage polarization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits limited clinical response to immunotherapy, highlighting the pressing need for novel strategies targeting its immunosuppressive microenvironment. While metabolic reprogramming and epigenetic alterations contribute to malignancy, the role of...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Irisin Restrains Oligodendroglial Ferroptosis to Preserve White Matter After Traumatic Brain Injury via AMPK Activation

ABSTRACT Traumatic brain injury (TBI) results in diffuse white matter (WM) damage, which is a major determinant of death and long‐term disability. Irisin, a myokine with promising neuroprotective effects, but whether irisin modulates WM injury after TBI remains unknown. Using a c...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1

Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was a...