First Affiliated Hospital of Zhengzhou University

Neutrophil to Lymphocyte Ratio and Neurological Outcome in Ischemic Stroke at 4.5 to 24 Hours: A Post Hoc Analysis of TRACE-III Trial

Whether neutrophil to lymphocyte ratio (NLR), as a marker of increased inflammatory response, modifies the efficacy and safety of tenecteplase is uncertain in patients 4.5–24 h after stroke onset. We investigated this in the Tenecteplase Reperfusion Therapy in Acute Ischemic Cere...

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

Mechanisms underlying loneliness in Parkinson’s disease: the mediating role of illness acceptance and the moderating effect of community self-efficacy

Patients with Parkinson’s disease (PD) are prone to social isolation and loneliness, and these issues worsen as the disease progresses. Although studies have reported links between social isolation and loneliness, the specific pathways underlying these associations remain unclear...

Uric acid-to-albumin ratio and all-cause mortality in dilated cardiomyopathy: a cohort-based prognostic analysis

Abstract Background Nutritional and metabolic abnormalities may contribute to adverse outcomes in dilated cardiomyopathy (DCM). The uric acid-to-albumin ratio (UAR), derived from two routinely measured biochemical parameters, may reflect this broader systemic burden. This study e...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

The Piezo1/Ca²⁺/NOTCH2 axis mediates matrix stiffness-induced osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Human bone marrow-derived mesenchymal stem cells (hMSCs) are key seed cells with multi‑lineage differentiation potential, and their osteogenic differentiation capacity forms the basis of bone regeneration. Extracellular matrix stiffness acts as a potent biophysical cue directing...

Sunlight-Triggered Bacterial Membrane-Targeting Aggregation-Induced Emission “Nanoantibiotic” Hydrogel for Ultrafast Multidrug-Resistant Bacteria Eradication and Diabetic Wound Healing

Abstract Drug-resistant bacterial infections and persistent biofilm formation pose critical bottlenecks for diabetic wound management. To overcome these challenges, a sunlight (SL)-triggered aggregation-induced emission (AIE) photosensitizer, designated as MTP, was engineered and...

Patient-family concordance in end-of-life decision-making preferences among terminally ill older adults: a cross-sectional study

Family members frequently participate in end-of-life (EOL) decision-making for terminally ill older adults; however, family-member preferences for the patient may not align with the patient’s own preferences. Such discordance can complicate treatment planning and efforts to provi...

A prognostic model for pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome based on sarcopenia

Sarcopenia has been shown to be associated with the prognosis of patients with liver cirrhosis, hepatocellular carcinoma, liver failure. However, the impact of sarcopenia on survival has not been investigated in patients with pyrrolizidine alkaloids (PAs)-induced hepatic sinusoid...

Dissection of Obesity‐Induced Spermatogenic Dysfunction at Single‐Cell Resolution

BACKGROUND: Obesity is a major risk factor for male infertility; however, how different obesity etiologies reshape testicular cellular states and transcriptional programs remains poorly understood. OBJECTIVES: This study aimed to characterize cell-type-specific transcriptional al...

Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials

Supporting materials for a systematic review and meta-analysis of randomised, placebo-controlled trials of semaglutide in adults with and without type 2 diabetes (PROSPERO CRD420261496524). Contents:(1) the standardised data extraction sheet used to record trial characteristics,...

Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials

Supporting materials for a systematic review and meta-analysis of randomised, placebo-controlled trials of semaglutide in adults with and without type 2 diabetes (PROSPERO CRD420261496524). Contents:(1) the standardised data extraction sheet used to record trial characteristics,...

Statin use and 28-day survival in critically ill patients with non-acute myocardial infarction cardiogenic shock

Evidence regarding statin therapy in non-acute myocardial infarction cardiogenic shock is limited, and retrospective medication studies are vulnerable to treatment-timing bias. We examined whether the association between statin exposure and 28-day mortality persisted after accoun...

Serial versus updated MELD for conditional 28-day mortality in critically ill patients with cirrhosis and sepsis: a landmark cohort study

Whether an admission-window Model for End-stage Liver Disease (MELD) score adds predictive information once an updated score is known remains uncertain in critically ill patients with cirrhosis and sepsis. We studied adults in MIMIC-IV v3.1 who were alive and hospitalized 72 h af...

Early tumor shrinkage and depth of response during treatment with immune checkpoint inhibitors as predictors of overall survival in patients receiving second-line or later therapy for advanced esophageal squamous cell carcinoma: a retrospective study

Early tumor shrinkage (ETS) and depth of response (DoR) reflect tumor response heterogeneity and may predict immunotherapy outcomes. This study evaluated the prognostic values of ETS and DoR in patients with advanced esophageal squamous cell carcinoma (ESCC) who received second-l...

Comparing the efficacy of bronchial artery chemoembolization combined with anlotinib versus anlotinib alone in the treatment of advanced non-small cell lung cancer

To compare the clinical effectiveness and safety of addition of anlotinib to bronchial artery chemoembolization (BACE) compared to anlotinib alone in the treatment of stage IIIA-IIIB non-small cell lung cancer (NSCLC) with no mutated driver genes. The clinical data of patients wi...

Transcription factor ELF-1 drives inflammatory macrophage to exacerbate AKI by GBP4/NLRs/NF-κB axis

Acute kidney injury (AKI) is an unavoidable complication and critical determinant of prognosis in renal transplantation. M1-polarized macrophages are known to exacerbate AKI progression. Preliminary clinical data reveals a positive correlation between elevated E74-like ETS transc...

A phase II trial of chemotherapy-free neoadjuvant camrelizumab plus apatinib for resectable HNSCC: pathological response and vascular-immune crosstalk

Abstract Purpose: To evaluate the efficacy, safety, and tumour microenvironment remodelling of neoadjuvant camrelizumab plus apatinib in resectable head and neck squamous cell carcinoma (HNSCC; stage II–IVA). Materials and Methods: In this single-arm, exploratory phase II trial (...

Early Hyperoxia and 28-day Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation: A Two-Center Retrospective Cohort Study

Objectives To evaluate the association between early arterial hyperoxia and 28-day mortality in postcardiotomy VA-ECMO (PC-ECMO) adult patients. Methods We conducted a retrospective cohort study including 209 adults who received PC-ECMO across two tertiary centers between January...