First Affiliated Hospital of Xi'an Jiaotong University

Breast cancer burden risk attribution and productivity loss in Chinese women aged 25 to 49

Breast cancer among Chinese women aged 25–49 years has substantial clinical and societal consequences. We integrated Global Burden of Disease (GBD) 2023 estimates for 1990–2023 with Global Cancer Observatory (GLOBOCAN) 2022, United Nations population projections, International La...

Prognostic impact of adjuvant chemoradiotherapy and genes methylation on localized urothelial carcinoma patients

In the management of muscle-invasive urothelial carcinoma, radiotherapy serves as an important adjuvant treatment to radical cystectomy. Evidence from other cancers indicates that synchronous chemoradiotherapy is associated with enhanced local control and survival outcomes when c...

Association of 5-hydroxytryptamine 3 receptor antagonists with prognosis in patients with advanced hepatocellular carcinoma: A propensity score-matched study

5-Hydroxytryptamine and its receptor are involved in hepatocarcinogenesis. This study investigated the effects of 5-hydroxytryptamine 3 receptor antagonists (5-HT3RAs) on the prognosis of patients with advanced hepatocellular carcinoma (HCC). Patients with advanced HCC who receiv...

Chronic Inflammation, Fibrotic Remodeling, and Regenerative Failure in Duchenne Muscular Dystrophy: Mechanisms and Therapeutic Opportunities

Duchenne muscular dystrophy (DMD) is an X-linked disorder initiated by dystrophin deficiency, but disease progression reflects more than sarcolemmal fragility. Recurrent myofiber injury sustains sterile inflammation through damage-associated innate immune signaling and downstream...

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

ABSTRACT Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system, and the 5‐year survival rate of GBC patients is only 5% due to delayed diagnosis. The sensitivity and specificity of existing clinical testing equipment for gallbladder malignancy remain i...

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

ABSTRACT Iron homeostasis plays a critical role in the pathogenesis and therapeutic management of hepatocellular carcinoma (HCC). Magnetoreceptor (MagR), also known as iron‐sulfur cluster assembly protein 1 (ISCA1), is a conserved protein maintaining iron homeostasis, plays an un...

Clinical and Functional Analysis of a HABP4 Missense Variant in Chinese Han Women With Endometriosis

Background: Endometriosis (EM) is a complex gynecological disease whose underlying molecular mechanisms remain poorly understood. The discovery of cancer driver mutations in endometriotic lesions indicates that EM may share common molecular pathways with malignant tumors. Our pre...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

Dynamic response and long-term operational performance of a ball double-screw hydraulic robotic joint actuator

Hydraulic joint actuators are important components in robotic motion systems, where dynamic response, force transmission stability, and long-term operational reliability are critical under repeated loading. However, conventional screw-based hydraulic joints often suffer from fric...

Association of neoadjuvant subcutaneous trastuzumab with higher pathological complete response in HER2-positive breast cancer: a real-world doubly robust study

Randomized trials have demonstrated the non-inferiority of subcutaneous (SC) versus intravenous (IV) trastuzumab. Its association with pathological complete response (pCR) in routine neoadjuvant practice warrants further study. The ability of serial ultrasound measurements to dis...

Tofacitinib therapy improves disease activity and is associated with the restoration of CD4+ regulatory T cell homeostasis in active Takayasu arteritis: a two-year prospective open-label cohort study

To investigate the efficacy of Tofacitinib (TOF) in patients with active Takayasu Arteritis (TAK), and to explore its effect on CD4 + regulatory T cells (Tregs) homeostasis and its relationship with clinical outcomes. This was a prospective, open-label cohort study. Thirty-four p...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus

The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activat...

Adaptive Approach Strategy for Efficient Scanning Ion Conductance Microscopy Based on Non-monotonic Approach Curves

Abstract Scanning ion conductance microscopy (SICM) enables high-resolution, noncontact, in situ characterization of specimens in liquid environments, providing simultaneous access to three-dimensional (3D) topographical, electrical, and mechanical properties. Despite its versati...

A dual-wavelength blue laser platform for integrated diagnosis and therapy in glioblastoma: preclinical evidence

Glioblastoma (GBM) remains clinically intractable owing to dismal prognosis and frequent recurrence. This study aimed to develop a dual-wavelength blue laser platform (450 nm and 405 nm) that integrates laser ablation, photodynamic diagnosis (PDD), and photodynamic therapy (PDT)...

Resolving closely spaced corners using second order Gaussian directional derivatives

Corner detection is a fundamental step in many computer vision tasks, including image matching and 3D reconstruction. However, closely spaced corners are difficult to distinguish because inappropriate smoothing scales may cause the filtered responses of neighboring structures to...

F13A1 enhances temozolomide resistance in glioblastoma via activation of the NF-κB signalling pathway

Acquired resistance to temozolomide (TMZ) is a principal driver of therapeutic failure and tumour recurrence in glioblastoma (GBM). This study sought to elucidate the molecular underpinnings of this resistance, aiming to identify viable prognostic markers and therapeutic targets...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Diurnal fluctuation of plasma Alzheimer’s disease biomarkers in healthy young Chinese adults

Plasma amyloid-β (Aβ) and phosphorylated tau (P-tau) are becoming biomarkers for Alzheimer’s disease (AD) diagnosis. However, the variation of plasma levels among different sampling times remains underexplored. In this study, we investigated the diurnal fluctuation of plasma biom...

Analysis of the awareness of core knowledge on lung cancer prevention and treatment among relatives of medical students

Abstract Background Medical students are well-positioned to share scientifically valid and precise information about lung cancer prevention with their families. This practice plays a crucial role in enhancing awareness of core knowledge on lung cancer prevention and treatment (CK...