First Affiliated Hospital of Jiangxi Medical College

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...

Endoscopic Retrograde Appendicitis Therapy Versus Laparoscopic Appendectomy for Acute Appendicitis: A 10-Year Single-Center Retrospective Cohort Study

INTRODUCTION: Endoscopic retrograde appendicitis therapy (ERAT) is a minimally invasive, organ-preserving treatment for acute appendicitis (AA), but comparative evidence with laparoscopic appendectomy (LA) remains limited.​. METHODS: We retrospectively analyzed 450 patients with...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

An interpretable deep learning model based on enhanced CT predicts the recurrence of non-muscle-invasive bladder cancer within 2 years

Accurate risk stratification for non-muscle-invasive bladder cancer (NMIBC) recurrence is essential for personalized treatment. This study aimed to develop and validate a contrast-enhanced computed tomography (CT)-based model for predicting postoperative NMIBC recurrence within t...

The relationship between biological rhythm disturbances and mixed features in major depressive episodes: a multicenter cross-sectional study

Major depressive episodes (MDEs) with mixed features are associated with greater clinical complexity and may represent an important indicator of bipolarity. Biological rhythm disturbances have been implicated in mood disorders, but their relationship with mixed features during MD...

NFS1 activates PI3K/AKT/mTOR signaling to upregulate GPX4 expression and enhance ferroptosis resistance in osteosarcoma

Osteosarcoma continues to exhibit poor survival outcomes due to chemoresistance and metastasis, with metabolic reprogramming and ferroptosis resistance being key features of tumor heterogeneity, yet their upstream regulators remain poorly defined. NFS1, a cysteine desulfurase ess...

ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome

Background Social dysfunction is a core symptom of autism spectrum disorder (ASD), including fragile X syndrome (FXS), but its underlying neural circuits and molecular mechanisms remain poorly understood. Previous studies have implicated the amygdala and hippocampus in social beh...

Multi‐Omics Genome‐Wide to Explore the Formation and Development Targets for Intracranial Aneurysms

Intracranial aneurysms (IAs) represent a significant and potentially life-threatening category of disease, and there is currently a lack of effective treatment options aimed at preventing the progression of the disease. Accordingly, this study is dedicated to exploring and identi...

The Translocation of Circular DNA with Variable Single/Double Strand Ratios through Solid-State Nanopores: Transition from Entropic Barriers to Crowding-Dominated Kinetics

Solid-state nanopores serve as powerful single-molecule analytical platforms for characterizing the physicochemical signatures of nucleic acids and proteins, yet prior work has focused almost exclusively on linear DNA, leaving circular DNA translocation poorly understood, particu...

Mitochondria–endoplasmic reticulum contacts as signaling platforms in chondrocyte homeostasis and osteoarthritis: from adaptive coupling to pathological amplification

Osteoarthritis (OA) is a progressive whole-joint disease in which cartilage degeneration remains a central pathological event. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are prominent features of chondrocyte dysfunction, but how these processes are coordinate...

Beyond the Meta‐Analysis: Reconsidering Class Effects, Resistance Surveillance, and Dosing Optimization in Tegoprazan–Amoxicillin Dual Therapy

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Prevalence and characteristics of colonic diverticulosis: a retrospective cross-sectional study in Southern China

Abstract Background Recent literature indicated that the prevalence of colonic diverticulosis in China is increasing. However, there is limited information on colonic diverticulosis in China. Our study aims to determine the prevalence and characteristics of colonic diverticulosis...

miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

ABSTRACT Aims Glioblastoma (GBM) remains the most lethal primary brain tumor, and the molecular mechanisms driving its aggressiveness are incompletely understood. Recent multi‐omics analyses have identified miR‐15a‐5p as one of the core microRNAs most closely associated with GBM....

PSMD14 reduced microglial M2 polarization to promote ferroptosis and aggravate traumatic brain injury through the induction of BMP6/SMAD3 pathway

The present study aimed to investigate the functional role of proteasome 26S subunit non-ATPase 14 (PSMD14) in traumatic brain injury (TBI) and further elucidate its molecular mechanisms linking ferroptosis to microglial M2 polarization. A total of 52 clinical samples from TBI pa...

Development and internal validation of an explainable machine learning model for predicting functional disability trajectories in hospitalized older patients with chronic low back pain

Functional disability poses a critical challenge to healthy aging in older patients with chronic low back pain (CLBP). However, understanding of heterogeneous functional disability trajectories in this population remains limited, and effective risk stratification tools are lackin...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA...

Itaconate as a central node in immunometabolism and inflammatory control

Mitochondria serve as central regulators of cellular bioenergetics and inflammatory signaling, integrating metabolic status with immune responses. Disruption of mitochondrial homeostasis, including altered tricarboxylic acid cycle dynamics, redox imbalance, and aberrant reactive...

Root-System-Inspired Core–Shell Microneedles Enable Spatiotemporal Sequential Therapy via ROS Scavenging, Angiogenesis, and Capillary-Driven Lipid Removal for Enhanced Fat Graft Survival

Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therape...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...