First Affiliated Hospital of Jiangxi Medical College

Root-System-Inspired Core–Shell Microneedles Enable Spatiotemporal Sequential Therapy via ROS Scavenging, Angiogenesis, and Capillary-Driven Lipid Removal for Enhanced Fat Graft Survival

Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therape...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Solute carrier family 25 member 32 promotes the proliferation of esophageal squamous cell carcinoma and is associated with immune infiltration

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly invasive and poorly prognosed malignant tumor of the digestive tract. Currently, there are no effective molecular classification markers for ESCC. This study screened out the key gene SLC25A32 based on mitochondrial-r...

Combined predictive value of MRI parameters and inflammatory biomarkers in assessing the severity and prognosis of acute cervical traumatic

Abstract Objective This study evaluated the combined predictive value of preoperative MRI variables and preoperative peripheral inflammatory biomarkers in assessing the severity and prognosis of acute cervical TSCI. Methods MRI parameters and peripheral inflammatory biomarkers we...

CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target

C-C motif chemokine ligand 2 (CCL2) interacts with cytokines, adipokines, miRNAs, and multiple synovial cell populations. Experimental studies indicate that these interactions can form a CCL2-associated inflammatory amplification network across cell types. In cellular and animal...

Comparative analysis of clinical characteristics of talaromycosis in HIV-positive and HIV-negative hosts

This study retrospectively analyzes the clinical characteristics of talaromycosis in human immunodeficiency virus (HIV)-positive and HIV-negative hosts. Seven cases of HIV-positive hosts and 23 cases of HIV-negative hosts infected with Talaromyces marneffei were collected. Their...

Proximal ProteomicsReveals Potential Regulators ofProgrammed Death-Ligand 1 in Human Cancer

Abstract Programmed death-ligand 1 (PD-L1) is a key mediator of tumor immune evasion, but the protein networks governing its post-translational regulation remain incompletely understood. Here, we used PhastID-based proximity labeling to map the PD-L1 proximal proteome and integra...

Association of the ZJU index with PSA-defined high-risk prostate cancer status and mortality: a population-based cohort study

Prostate cancer (PCa) ranks among leading causes of male cancer mortality, but PSA screening lacks specificity. Metabolic dysregulation drives PCa pathogenesis; however, composite metabolic indices remain underexplored. The ZJU index—integrating BMI, fasting glucose, triglyceride...

Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state

Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that promotes cardiomyocyte proliferation and hea...

Integrated inference of cellular compositions and gene expression programs by deconvolution

While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic challenge. Consequently, accurate single-sa...

METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the MiR-193b-3p/KCNJ2/NLRP3 axis

<title>Abstract</title> The authors have requested that this preprint be removed from Research Square due to a pending patent application.

Peer victimization and family dynamics in the association between childhood abuse and adolescent non-suicidal self-injury: a cross-sectional moderated mediation study

Childhood abuse is associated with adolescent non-suicidal self-injury (NSSI), but the roles of proximal peer experiences and family context remain unclear. A cross-sectional survey was conducted among 10,179 Chinese students (47.9% female; Mage = 14.16 years, SD = 1.86). A theor...

HE-referenced eosinophil assessment and cutoff estimation using Congo red and Chromotrope 2R staining in chronic rhinosinusitis with nasal polyps

Abstract This cross-sectional histopathological study aimed to compare eosinophil visualization and quantification using Congo red, Chromotrope 2R, and conventional hematoxylin–eosin (HE) staining in chronic rhinosinusitis with nasal polyps (CRSwNP), and to explore HE-referenced...

Antifungal Effects of Plant Extracts on Saffron Corms Infected with Three Pathogens

Background: Saffron corm rot causes significant yield losses worldwide. Although synthetic pesticides are commonly used for management, their overuse can lead to increased fungal resistance and pose a risk to public health. Numerous plants possessing antifungal properties hold si...