First Affiliated Hospital of Jiangxi Medical College

Probiotics modulate the interactions between gastric and intestinal microbiota after Helicobacter pylori eradication

Standard eradication therapy for Helicobacter pylori ( H. pylori ) induces substantial gastrointestinal dysbiosis. Here, we investigated whether probiotic supplementation mitigates these spatial microbial perturbations and facilitates ecological recovery post-eradication. C57BL/6...

Targeting GGT1 via RGD-modified lipid nanoparticles suppresses breast cancer lung metastasis by disrupting exosome-mediated angiogenesis

Breast cancer lung metastasis remains a major cause of mortality, largely because effective treatment options are limited. In this study, we identify gamma-glutamyltransferase 1 (GGT1) as a factor associated with breast cancer lung metastatic progression. Analyses of clinical dat...

Emerging frontiers in targeted and immunotherapeutic strategies for marginal zone lymphoma

Marginal zone lymphoma (MZL) comprises a heterogeneous group of indolent B-cell non-Hodgkin lymphomas. Most patients have favorable outcomes, but approximately 20% develop early relapse or progression within 24 months. Advances in molecular profiling have identified recurrent alt...

Development and validation of the Environment-Technology-Task Model-based self-assessment scale for intraoperative rescue readiness among operating room nurses

This study aimed to develop and validate a self-assessment scale based on the Environment-Technology-Task Model to evaluate operating room nurses’ readiness for intraoperative rescue and to evaluate its psychometric properties. A methodological study focusing on the development a...

The relationships among achievement motivation health related physical fitness and academic procrastination in adolescents from a multitheoretical perspective

Academic procrastination among adolescents is a complex phenomenon associated with multiple factors. This study aimed to examine the associations among achievement motivation, health-related physical fitness, and academic procrastination in adolescents. A cross-sectional study de...

Hypoxia-inducible factor as a master switch in ocular neovascularization: overcoming anti-VEGF resistance and exploring therapeutic prospects

Abstract Hypoxia-inducible factor (HIF) is a key driver of ocular neovascular diseases. We systematically discuss its regulatory mechanisms and pathological roles in diabetic retinopathy (DR), retinopathy of prematurity (ROP), and neovascular age-related macular degeneration (nAM...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Physical activity and the prevalence of hypertension, hyperglycaemia, hyperlipidaemia, and their co-occurrence among middle-aged and older Chinese adults

Hypertension, hyperglycaemia, and hyperlipidaemia, collectively referred to as the “three highs” (3H), pose significant health risks globally. Physical activity (PA) is associated with cardiometabolic health; however, the associations of PA with individual and concurrent 3H condi...

Potential role of ZG16 overexpression in malignant behaviors and macrophage phagocytosis in vitro

Despite extensive research, the key molecular regulators driving Colorectal Cancer (CRC) progression remain poorly defined. We analyzed bulk RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA) database to assess ZG16 expression, Gene Set Enrichment Analysis (GSEA),...

A nationwide study of pathogens in hospitalized patients with lower respiratory tract infections by metagenomic next-generation sequencing

ABSTRACT Lower respiratory tract infections remain a major cause of morbidity and mortality, yet timely etiologic diagnosis is difficult because of the breadth of possible pathogens and the limitations of conventional microbiological tests. We retrospectively analyzed 30,819 clin...

Moringa oleifera Leaf-Derived Exosome-Like Nanoparticles Target Macrophage Senescence to Drive M2 Polarisation and Attenuate Alveolar Bone Loss

Background Periodontitis is a chronic inflammatory disease characterised by progressive alveolar bone loss. Macrophages play a pivotal role in coupling inflammation to disrupted bone metabolism, and their dysregulation is a key driver of bone resorption. However, precise therapeu...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Construction of an m5Cscore based on m5C modification patterns to predict prognosis and personalized treatment outcomes in breast cancer

Accumulating evidence links 5-methylcytosine (m 5 C) modifications to tumor progression and gene regulation. This study aimed to systematically characterize m 5 C modification patterns in breast cancer, elucidate their associations with prognosis and tumor heterogeneity, and prov...

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

Abstract Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunoth...

The prognostic value of eGDR in prediabetes outcomes: a sex-stratified prospective cohort study

Abstract Background Prediabetes is a critical phase that precedes the development of diabetes, characterized by insulin resistance as a key driver of its advancement. The estimated glucose disposal rate (eGDR) reflects insulin sensitivity, but its sex-specific prognostic value is...

Resveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling

Background Resveratrol has been shown to play a neuroprotective role in diabetic cognitive dysfunction. We determined whether resveratrol improved diabetic cognitive dysfunction through ferroptosis regulation, and explored the potential mechanism. Methods Rats were fed with a hig...

Deubiquitinase USP48 Promotes Gastric Cancer Peritoneal Metastasis by Stabilizing S100A9 to Drive Neutrophil Extracellular Traps Formation

ABSTRACT Peritoneal metastasis (PM) represents the primary cause of death in patients with advanced gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Neutrophil extracellular traps (NETs) have emerged as key mediators of tumor progression, but how cance...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...