First Affiliated Hospital of GuangXi Medical University

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Factors associated with blood flow velocity in the upper limb of cancer patients with peripherally inserted central catheters: a cross-sectional study

Abstract Background Peripherally inserted central catheters (PICC) are widely used in cancer care for long-term intravenous access, yet complications such as thrombosis remain a concern. Blood flow velocity is a key hemodynamic parameter closely associated with thrombosis risk. H...

Joint associations of comorbidity burden and polypharmacy with depressive symptoms, and joint effects of comorbidity burden, polypharmacy, and depressive symptoms on all-cause mortality among US adults aged 45 years and older: a dual cross-sectional and cohort study

Although comorbidity burden and polypharmacy are increasingly prevalent among middle-aged and older adults and may contribute to depressive symptoms, evidence on their joint associations remains scarce. Furthermore, the combined impact of comorbidity burden, polypharmacy, and dep...

The worth of diffusion-weighted imaging for quantifying liver iron concentration in transfusion-dependent thalassemia patients

Background Magnetic resonance imaging (MRI) is currently the primary method for evaluating liver iron concentration (LIC); however, most techniques necessitate intricate data post-processing. Consequently, the development of simple quantitative methods is highly desirable. Purpos...

NFS1 activates PI3K/AKT/mTOR signaling to upregulate GPX4 expression and enhance ferroptosis resistance in osteosarcoma

Osteosarcoma continues to exhibit poor survival outcomes due to chemoresistance and metastasis, with metabolic reprogramming and ferroptosis resistance being key features of tumor heterogeneity, yet their upstream regulators remain poorly defined. NFS1, a cysteine desulfurase ess...

Development and validation of a clinical prediction model for gastrointestinal hemorrhage in pediatric IgA vasculitis

To develop and internally validate a preliminary clinical prediction model for incident gastrointestinal hemorrhage (GH) occurring after admission in children with IgA vasculitis (IgAV), with continuous laboratory predictors retained in original scale to maximize predictive infor...

Circulating miR-378a-3p as a molecular biomarker in pediatric duchenne muscular dystrophy

Abstract Early and accurate diagnosis of Duchenne muscular dystrophy (DMD) remains challenging in children with elevated creatine kinase (CK), as CK is sensitive but lacks disease specificity. Circulating microRNAs have emerged as potential biomarkers for muscle pathophysiology....

Dose-response relationship between metabolic disease burden and myocardial deformation: a confounder-adjusted linear regression analysis

Metabolic diseases are increasingly recognized as contributors to cardiac dysfunction, but the dose–response relationship between metabolic disease burden and myocardial deformation remains unclear. This single-center retrospective study included ST-segment elevation myocardial i...

Serum albumin-creatinine ratio predicts sarcopenia and poor outcomes in patients with colorectal cancer

Abstract Background: This study was designed to explore the prognostic significance of the serum albumin-creatinine ratio (ACR) in patients with colorectal cancer (CRC). Methods: Kaplan-Meier survival analysis was utilized to evaluate overall survival (OS) and progression-free su...

Oral Health Knowledge, Attitudes, and Practices among Pregnant Women in Routine Prenatal Care in South China: A Cross‐Sectional Survey

BACKGROUND: Physiological changes during pregnancy can increase the risk of oral diseases in women, which may directly affect the health status of their newborns. This cross-sectional study aims to assess the oral health knowledge, attitudes, and practices of pregnant women in So...

Patients’ perceptions of male and female nursing interns in Guangdong and Guangxi, Southern China

Nursing remains female-dominated globally, with gender stereotypes hindering workforce diversity. Male nurses account for 2% to 5% of China’s nursing workforce, and Guangdong/Guangxi lack studies on patients’ perceptions of male nursing interns. This study aims to explore relatio...

Exploration of acetylation-related biomarkers in osteoarthritis through bioinformatics analysis

Osteoarthritis (OA) is characterized as a chronic degenerative disorder affecting the joints. A growing body of evidence indicates that acetylation may play a role in the disease’s pathogenesis. However, the underlying molecular mechanisms remain largely undefined. The objective...

AKR7A3 rs1738023 association with susceptibility to female hepatocellular carcinoma and its role in AFB1 metabolism and tumor

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide. In this study, we performed a two-stage exome-chip association analysis and found that the aldo-keto reductase family7 member A3 (AKR7A3) rs1738023 may be a potential susceptibility loc...

Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder in an adolescent with inflammatory polyarthritis and Sjögren-related features: a case report

Neuromyelitis optica spectrum disorder (NMOSD) is a severe immune-mediated astrocytopathy most commonly associated with aquaporin-4 immunoglobulin G (AQP4-IgG). Optic neuritis is a common phenotype in pediatric NMOSD, but diagnosis may be delayed when early magnetic resonance ima...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation

Objective This study aims to investigate the potential protective effects of Achyranthes bidentata polysaccharides (ABPS) against severe traumatic brain injury (sTBI) and to elucidate the underlying mechanisms. Methods A sTBI model was established using a modified free-fall impac...

Early prediction of novel dynamic subphenotypes in acute pancreatitis with hypertriglyceridemia: a multicenter cohort study

Concomitant with the escalating global burden of metabolic disorders, acute pancreatitis with hypertriglyceridemia (AP-HTG) has become highly prevalent. However, the initial triglyceride elevation does not strictly correlate with adverse clinical outcomes. Therefore, we aimed to...

Integrative transcriptomic and machine learning analyses identify NOL7 and TXLNA as candidate blood biomarkers for Parkinson’s disease within an RNA modification-associated co-expression network

Abstract Background Parkinson’s disease (PD) pathogenesis involves complex molecular mechanisms, with emerging evidence implicating RNA modifications (RM). This study sought to explore RM-associated key genes and their roles in PD progression. Methods Transcriptomic datasets GSE6...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...