First Affiliated Hospital of GuangXi Medical University

Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder in an adolescent with inflammatory polyarthritis and Sjögren-related features: a case report

Neuromyelitis optica spectrum disorder (NMOSD) is a severe immune-mediated astrocytopathy most commonly associated with aquaporin-4 immunoglobulin G (AQP4-IgG). Optic neuritis is a common phenotype in pediatric NMOSD, but diagnosis may be delayed when early magnetic resonance ima...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

Early prediction of novel dynamic subphenotypes in acute pancreatitis with hypertriglyceridemia: a multicenter cohort study

Concomitant with the escalating global burden of metabolic disorders, acute pancreatitis with hypertriglyceridemia (AP-HTG) has become highly prevalent. However, the initial triglyceride elevation does not strictly correlate with adverse clinical outcomes. Therefore, we aimed to...

Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation

Objective This study aims to investigate the potential protective effects of Achyranthes bidentata polysaccharides (ABPS) against severe traumatic brain injury (sTBI) and to elucidate the underlying mechanisms. Methods A sTBI model was established using a modified free-fall impac...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Integrative transcriptomic and machine learning analyses identify NOL7 and TXLNA as candidate blood biomarkers for Parkinson’s disease within an RNA modification-associated co-expression network

Abstract Background Parkinson’s disease (PD) pathogenesis involves complex molecular mechanisms, with emerging evidence implicating RNA modifications (RM). This study sought to explore RM-associated key genes and their roles in PD progression. Methods Transcriptomic datasets GSE6...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...

MiPEP133 enhances anti-tumor immunity in nasopharyngeal carcinoma by activating CD8 + T cells

Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. RNA-Seq was used to assess miPEP133’s effect on NPC cells and T-cell-...

Activation of PPARγ attenuates neuropathic pain by modulating spinal cuproptosis-associated mitochondrial dysfunction and neuroinflammation

Abstract Cuproptosis is a recently identified form of programmed cell death driven by copper accumulation. Increasing evidence suggests that copper dyshomeostasis contributes to neuroinflammatory processes. Peroxisome proliferator-activated receptor gamma (PPARγ) activation has b...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

Development and validation of a nomogram prediction model for mild pulmonary arterial hypertension risk in children with left-to-right shunt congenital heart disease

Mild pulmonary arterial hypertension (PAH) represents an early and potentially reversible complication stage in children with congenital structural heart disease (CHD). Early identification of high-risk children is crucial for improving prognosis. This study aimed to develop and...

Mast cell–derived SPP1 promotes colorectal cancer liver metastasis by suppressing BTG1-mediated JUN degradation

The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism. The bulk-seq, scRNA-seq datasets and clinical samples were integrated to identi...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

Association of uric acid, lipid and bone metabolic markers with temporomandibular joint osteoarthritis: a cross-sectional study

Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with a complex and multifaceted etiology. Although metabolic disturbances have been linked to osteoarthritis in other joints, their role in TMJOA remains unclear. This study aimed to investigate the associat...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Methylation-sensitive restriction endonuclease-based amplification assay for detecting DNA methylation in colorectal cancer: a cross-sectional study

Abstract Background This study evaluates the clinical utility of combined SDC2 and ADHFE1 methylation analysis for colorectal cancer (CRC) detection using a methylation-sensitive restriction endonuclease (MSRE)-based assay. Methods Leveraging the specificity of MSRE, we developed...

Bioinformatics-based analysis of key genes associated with endoplasmic reticulum stress in myocardial infarction

Abstract Background Endoplasmic reticulum stress (ERS) is a critical pathological factor that drives myocardial infarction (MI) progression. This study aimed to screen and validate core ERS-related hub genes involved in acute myocardial infarction (AMI) pathogenesis by integratin...

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

levels, downregulation of GPX4, and accumulation of lipid peroxidation. A genome-wide CRISPR/Cas9 knockout screen identified EXOC7 as a critical mediator of 6PPD-Q-induced podocyte injury. Mechanistically, 6PPD-Q disrupted the E3 ubiquitin ligase activity of MARCHF2, leading to r...