First Affiliated Hospital of GuangXi Medical University

Malnutrition defined by three global leadership initiative on malnutrition‐based models and the risk of all‐cause mortality in adults with common cancers: A retrospective cohort study

Abstract Objective Our study compared the diagnostic agreement and prognostic value for overall survival of three nutritional screening tools integrated with the Global Leadership Initiative on Malnutrition framework in patients with cancer. Methods The nutritional screening tool...

Theca cell monolayer co-culture improves oocyte in vitro maturation and subsequent embryo development in buffalo (Bubalus bubalis)

Theca cells (TCs) are essential regulators of both follicular development and regression, as they produce androgens that serve as precursors for granulosa cell aromatization. The present study aimed to examine the effects of TC monolayer co-culture on oocyte in vitro maturation (...

mTORC1 Activation Links Chronic Stress to Meso‐Circuit Desynchronization and Accelerated Amyloid Pathology via Autophagic Dysfunction

ABSTRACT Background Although depression is a potent risk factor for Alzheimer's disease (AD), the underlying causal mechanisms remain unclear. This study investigated the molecular and circuit‐level mechanisms linking chronic stress to accelerated AD pathogenesis and evaluated th...

Interpretable machine learning-based model for predicting postoperative urinary tract infection after minimally invasive surgery for upper urinary tract calculi: development and external validation

This study sought to develop and externally validate an interpretable machine learning–based model to predict the risk of urinary tract infection (UTI) following minimally invasive surgery (MIS) in patients with upper urinary tract calculi. Clinical data from patients suffering u...

Machine-learning-based prediction of acute and late-onset skin reactions after neoadjuvant chemoradiotherapy for rectal cancer: a retrospective cohort study

Abstract To develop and validate machine learning models for predicting acute and late radiation-induced skin reactions in patients with locally advanced rectal cancer who received neoadjuvant chemoradiotherapy. This retrospective analysis included 358 patients with locally advan...

Escalating global burden of female infertility

This study explores the global burden of female infertility across 204 countries and 21 regions from 1990 to 2021. The population-based study analyzed was conducted using data from the Global Burden of Disease 2021. We assessed age-standardized prevalence rate (ASPR), age-standar...

FGF21 Pretreatment Promotes the Cardioprotective Effects of Mesenchymal Stem Cells in Myocardial Infarction via Enhancement of Their Survival and Paracrine Effects

Background: The poor engraftment of mesenchymal stem cells (MSCs) in the ischemic heart post transplantation heavily restricts their cardioprotective benefits in myocardial infarction (MI). Pretreatment has emerged as a novel approach to enhance the biological properties of MSCs...

Toxicities of cancer immunotherapy: clinical manifestations, underlying mechanisms, and management

Abstract Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has transformed the treatment landscape of multiple malignancies. However, dysregulated immune activation can cause a wide range of toxicities tha...

Monotropein mitigates atherosclerotic plaque vulnerability through circ_0140736/miR-495/SIRPα-mediated efferocytosis

Efferocytosis is a biological process in which phagocytic cells engulf and degrade senescent, damaged, or dead cells to prevent secondary necrosis and inflammation. This process is implicated in various diseases, including atherosclerosis (AS). Enhancing efferocytosis efficiency...

Altered EEG microstate dynamics and cortical structure-function associations in temporal lobe epilepsy with FBTCS

This study aimed to characterize alterations in electroencephalographic (EEG) microstate dynamics and their structural correlates in patients with temporal lobe epilepsy (TLE) with and without focal to bilateral tonic-clonic seizures (FBTCS). A total of 37 patients with TLE and a...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

The marine drug plitidepsin alleviates osteoporosis in estrogen-deficient mice by suppressing ROS-mediated NRF2/HO-1 signaling and osteoclast formation

Abstract Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored. This study investigated the effects of plitideps...

Development and validation of an intratumoral–peritumoral radiomics-clinical model for preoperative prediction of synchronous liver metastasis in pancreatic neuroendocrine tumors

Synchronous liver metastasis is an important prognostic factor in patients with pancreatic neuroendocrine tumors (PNETs). Imaging features of the primary tumor may provide information on metastatic propensity beyond direct assessment of the liver, but the contribution of the peri...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Neuroticism increased risk of gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that severely reduces quality of life. Emerging data suggest that neuroticism, a personality trait associated with increased stress reactivity and sensitivity to physiological sensations, may contribute...

Missed deep ovarian pregnancy behind a ruptured corpus luteum: the value of postoperative β-hCG and methotrexate

Abstract Background Ovarian pregnancy accounts for only 0.5-3% of ectopic pregnancies. Its coexistence with a ruptured corpus luteum is exceptionally rare and creates a diagnostic challenge that can lead to incomplete treatment and persistent trophoblastic disease. Case presentat...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Characterisation of whole-blood extrachromosomal circular DNAs in Kawasaki disease complicated by coronary artery aneurysm

Abstract Background: Extrachromosomal circular DNAs are critical regulators of stress responses, immunity, and inflammation pathways. However, their role and underlying mechanisms in Kawasaki disease complicated by coronary artery aneurysm remain poorly understood. Methods: Whole...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation

Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the relationship between circulating S100B levels and OSAHS has not been...