First Affiliated Hospital of Fujian Medical University

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

The STRIDE II consensus recognizes histopathological healing in ulcerative colitis as a key therapeutic target. This study aimed to develop and internally evaluate a quantitative image-based model for the binary classification of mild versus moderate-to-severe UC based on histopa...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Preoperative vascular status, left colic artery management, and clinically relevant anastomotic leakage after anterior resection for rectal cancer: a retrospective cohort study

Clinically relevant anastomotic leakage after rectal cancer surgery is multifactorial, and baseline vascular status may contribute to anastomotic perfusion risk. This study evaluated the associations of patient-level vascular comorbidity, preoperative CT/CTA-derived vascular stat...

Histamine and H1R regulate microglia in an IDPN-Induced Mouse Model of Tic-like behaviors

Tic disorder (TD) is a developmental neurological condition characterized by pathological motor and/or vocal tics. Accumulating evidence suggests that central histamine (HA) participates in the onset and development of TD. Recent research highlights HA’s role in neuroinflammation...

Metal artifact reduction sequence MRI in hip periprosthetic joint infection management

Aims: There is currently no validated noninvasive method to determine infection control prior to prosthesis reimplantation during the two-stage revision process for hip periprosthetic joint infections (PJI) after total hip arthroplasty (THA). This prospective study investigates w...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Establishment of an enteral nutrition pathway for malignant esophageal obstruction using combined esophageal stenting and gastrostomy

Malnutrition is common in patients with advanced esophageal cancer and is associated with poor outcomes. While esophageal stenting can relieve dysphagia, oral intake alone is often insufficient. Percutaneous endoscopic gastrostomy (PEG) provides reliable nutritional support but d...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Role of intermittent hypoxia in the dysregulation of serum uric acid levels in non-obese adults with obstructive sleep apnea syndrome

This study investigated the association between serum uric acid (SUA) and obstructive sleep apnea syndrome (OSAS) and identified risk factors for elevated SUA in non-obese patients. Consecutive non-obese patients referred to the sleep center for suspected OSAS were included. Corr...

Optimizing Vanadium Single‐Atom Nanozyme via Cluster‐Mediated Charge Orchestration for Modulating Immune Homeostasis in Intracerebral Hemorrhage

ABSTRACT Intracerebral hemorrhage (ICH) triggers excessive reactive oxygen species (ROS) accumulation and persistent neuroinflammation, which synergistically drive progressive neuronal damage and poor neurological functional recovery, severely restricting patient prognosis. Artif...

Tetrahedral DNA nanostructure–gated solution-phase CRISPR/Cas12a system for probe immobilization-free, reagent-efficient, and dual-phase electrochemical detection of circulating microRNAs in liquid biopsy

Liquid-biopsy nucleic acid biomarkers hold strong promise for non-invasive cancer diagnostics, yet their ultralow abundance presents substantial analytical challenges. Conventional electrochemical biosensors rely on complex probe immobilization, whereas emerging homogeneous strat...

Five-year surveillance of pediatric respiratory pathogens in Fuzhou (2019–2024): impact of the COVID-19 pandemic

This study aims to investigate the epidemiological characteristics and distribution patterns of respiratory pathogens in children in Fuzhou between 2019 and 2024, with a particular focus on changes associated with the COVID-19 pandemic. This retrospective study included children...

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Risk stratification of long-term distant metastasis in nasopharyngeal carcinoma: a retrospective study of 7,045 patients diagnosed from 2012 to 2022

Distant metastasis (DM) remains the leading cause of treatment failure in nasopharyngeal carcinoma (NPC), severely compromising long-term survival. Despite advances in screening and multimodal therapies, a considerable proportion of patients still develop DM after standard treatm...

Virtual reality-assisted rehabilitation after arthroscopic rotator cuff repair for small-to-medium supraspinatus tears: a prospective assessor-blinded randomized controlled trial

Rehabilitation after arthroscopic rotator cuff repair (ARCR) must protect the repair while restoring active shoulder use. Immersive virtual reality (VR) can standardize rehabilitation tasks and provide immediate feedback, but whether VR delivery offers benefit over conventional d...

Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study

This study used data from the China Health and Retirement Longitudinal Survey (CHARLS) to examine the association between adverse childhood experiences (ACEs) and accelerated aging in middle-aged and older Chinese, with implications for healthy aging interventions. A total of 832...