First Affiliated Hospital of Fujian Medical University

Role of intermittent hypoxia in the dysregulation of serum uric acid levels in non-obese adults with obstructive sleep apnea syndrome

This study investigated the association between serum uric acid (SUA) and obstructive sleep apnea syndrome (OSAS) and identified risk factors for elevated SUA in non-obese patients. Consecutive non-obese patients referred to the sleep center for suspected OSAS were included. Corr...

Optimizing Vanadium Single‐Atom Nanozyme via Cluster‐Mediated Charge Orchestration for Modulating Immune Homeostasis in Intracerebral Hemorrhage

ABSTRACT Intracerebral hemorrhage (ICH) triggers excessive reactive oxygen species (ROS) accumulation and persistent neuroinflammation, which synergistically drive progressive neuronal damage and poor neurological functional recovery, severely restricting patient prognosis. Artif...

Tetrahedral DNA nanostructure–gated solution-phase CRISPR/Cas12a system for probe immobilization-free, reagent-efficient, and dual-phase electrochemical detection of circulating microRNAs in liquid biopsy

Liquid-biopsy nucleic acid biomarkers hold strong promise for non-invasive cancer diagnostics, yet their ultralow abundance presents substantial analytical challenges. Conventional electrochemical biosensors rely on complex probe immobilization, whereas emerging homogeneous strat...

Five-year surveillance of pediatric respiratory pathogens in Fuzhou (2019–2024): impact of the COVID-19 pandemic

This study aims to investigate the epidemiological characteristics and distribution patterns of respiratory pathogens in children in Fuzhou between 2019 and 2024, with a particular focus on changes associated with the COVID-19 pandemic. This retrospective study included children...

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Risk stratification of long-term distant metastasis in nasopharyngeal carcinoma: a retrospective study of 7,045 patients diagnosed from 2012 to 2022

Distant metastasis (DM) remains the leading cause of treatment failure in nasopharyngeal carcinoma (NPC), severely compromising long-term survival. Despite advances in screening and multimodal therapies, a considerable proportion of patients still develop DM after standard treatm...

Virtual reality-assisted rehabilitation after arthroscopic rotator cuff repair for small-to-medium supraspinatus tears: a prospective assessor-blinded randomized controlled trial

Rehabilitation after arthroscopic rotator cuff repair (ARCR) must protect the repair while restoring active shoulder use. Immersive virtual reality (VR) can standardize rehabilitation tasks and provide immediate feedback, but whether VR delivery offers benefit over conventional d...

Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study

This study used data from the China Health and Retirement Longitudinal Survey (CHARLS) to examine the association between adverse childhood experiences (ACEs) and accelerated aging in middle-aged and older Chinese, with implications for healthy aging interventions. A total of 832...