First Affiliated Hospital of Fujian Medical University

γ‐Radionuclide Technetium‐99M Activated Long‐Lasting Chemodynamic Therapy and Immunogenic Brachytherapy for Enhanced Antitumor Immunity

ABSTRACT Chemodynamic therapy (CDT) and brachytherapy face critical challenges, particularly the limited efficiency of Fenton reaction and the insufficient antitumor immunogenicity of brachytherapy. In this study, we employ the metal–organic framework nanocomposite Hf‐TCPP@Fe‐ 99...

Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression

Objectives The role of the sympathetic neurotransmitter norepinephrine (NE) in ulcerative colitis (UC) remains controversial. We aimed to elucidate NE's precise mechanisms in UC, focusing on colonic metabolism, diagnostic potential, and local immune interactions. Methods Colonic...

Multiple classification of childhood and juvenile autism spectrum disorder from ABIDE-II sMRI using BN-GO-CNN

Abstract Objectives Autism spectrum disorder (ASD) shows heterogeneous neurodevelopmental patterns across childhood, juvenile development, and adulthood, so binary MRI classification may not fully capture age-and sex-related variation. This study proposes a proof-of-concept frame...

Vasoepididymostomy‐First Versus Primary ICSI for Epididymal Obstructive Azoospermia: Real‐World Reproductive Outcomes for Treatment Selection

ABSTRACT Background In couples with epididymal obstructive azoospermia (EOA), choosing between microsurgical vasoepididymostomy (MVE)‐first and primary intracytoplasmic sperm injection (ICSI) remains a practical treatment‐selection challenge. Conventional endpoints such as patenc...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Quantitative liver stiffness and steatosis burden in subclinical carotid atherosclerosis: associations and incremental utility assessed by explainable machine learning

Whether quantitative liver steatosis and stiffness provide vascular-risk information beyond conventional cardiometabolic factors remains uncertain. We evaluated their multivariable-adjusted associations and incremental utility for identifying subclinical carotid atherosclerosis....

High prevalence and immunophenotypic diversity of clonal T‑large granular lymphocytes in JAK2‑mutated myeloproliferative neoplasms

Patients with JAK2‑mutated MPN may develop clonal T‑cell expansions, but the prevalence, immunophenotypic spectrum, and association with other lymphoid clones remain poorly defined. Clonal T‑large granular lymphocyte (T‑LGL) expansions have been observed in myeloproliferative neo...

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

BACKGROUND: Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranaceus, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD), though its mechanisms remain unclear. PURPOSE: This study aimed to elucidate how AS-IV alleviates h...

Bibliometric analysis of global research activity and emerging trends in radioiodine refractory differentiated thyroid cancer

Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) remains a critical challenge and focal point in thyroid cancer management, garnering increasing attention and discourse among both the public and scientific community in recent years. To date, however, no comprehensi...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Development and validation of a diagnostic model for prevalent liver-related events in patients with non-alcoholic fatty liver disease

The burden of liver-related events (LREs) among hospitalized patients with non-alcoholic fatty liver disease (NAFLD) is substantial. We developed a diagnostic model based on routine clinical parameters to estimate the probability of prevalent LREs status ascertained during the in...

Early renal replacement therapy and short-term mortality in higher-risk KDIGO stage 2 sepsis-associated acute kidney injury with sustained oliguria: a target trial emulation

Abstract Whether proactive early renal replacement therapy (RRT) improves outcomes in higher-risk patients with KDIGO stage 2 sepsis-associated acute kidney injury (SA-AKI) and sustained oliguria remains uncertain. We evaluated its association with short-term mortality. We emulat...

A proteome-derived inflammatory epithelial-myeloid state is associated with adverse outcome in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is molecularly heterogeneous, and the cellular basis of adverse bulk-omics states is often unclear. We examined whether a proteome-derived prognostic score reflects an inflammatory malignant epithelial-myeloid state. A score derived from Fuda...

Development and validation of a nomogram for predicting 28-day mortality in critically ill liver cirrhotic patients with coagulopathy

Although scoring systems exist to predict outcomes in patients with cirrhosis, specific systems for critically ill cirrhotic patients with coagulopathy are lacking. The aim of the study was to establish a reliable predictive model for 28-day mortality in cirrhotic patients with c...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Repurposing diuretics for bipolar disorder: a Mendelian randomization study

Despite increasing therapeutic options to treat bipolar disorder (BD), many patients fail to reach treatment targets. The study sought to explore the potential of diuretics in preventing and treating BD through Mendelian randomization (MR). We utilized a two-sample MR design to a...

Intraluminal thrombus distribution pattern is associated with abdominal aortic aneurysm rupture at presentation: a single-centre retrospective study

Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA), yet its role in rupture remains incompletely defined. This study examined whether the circumferential distribution pattern of ILT—classified as circumferential, eccentric, or absent/minima...

Hemodynamic prediction of postoperative recurrence in trigeminal neuralgia associated with vertebrobasilar dolichoectasia: development of a nomogram model

Trigeminal neuralgia caused by vertebrobasilar dolichoectasia (VBD-TN) demonstrates a higher postoperative recurrence rate following microvascular decompression (MVD) than typical vascular compression. This study aimed to develop a clinical prediction model incorporating hemodyna...

Gut Microbiota and Aldosterone Regulate Natriuretic Peptide B Expression to Drive Mitophagy and Metabolic Reprogramming in Sepsis‐Like Model of Myocardial Injury

BACKGROUND: Myocardial injury is a major contributor to mortality in sepsis, yet the mechanisms underlying gut-heart communication in sepsis-induced myocardial injury remain insufficiently defined. Natriuretic peptide B (NPPB) is a cardiac stress-responsive gene, but its involvem...

Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries

Geographic definitions of the tropics may obscure substantial climatic heterogeneity. Climate classification provides a more ecologically meaningful framework for evaluating inflammatory bowel disease (IBD) in tropical settings. However, few studies have examined tropical IBD bur...