First Affiliated Hospital of Bengbu Medical College

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Changing clinical spectrum and hospital burden of pulmonary aspergillosis before and during the COVID-19 era: a 15-year single-center retrospective study

Abstract Background Pulmonary aspergillosis (PA) encompasses a heterogeneous spectrum of fungal diseases, including invasive, chronic, and allergic forms. The hospital burden and clinical characteristics of PA during the COVID-19 era remain incompletely understood. Methods We con...

Differential circadian time modulates of dentate gyrus and CA1 excitation-inhibition balance and seizure threshold

Abstract Circadian rhythms regulate seizure threshold and neuronal excitability in epilepsy. Temporal lobe seizures tend to arise more frequently during the diurnal phase relative to the nocturnal phase, yet dentate gyrus (DG) granule cells display elevated intrinsic excitability...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Reliability and validity of the modified chinese version of new Cleveland clinic colorectal cancer quality of life questionnaire

The New Cleveland Clinic Colorectal Cancer Quality of Life Questionnaire (CCF-CaQL) was developed to assess postoperative quality of life (QoL) in patients with colorectal cancer (CRC). Since its introduction, it has been validated in several countries. This study aimed to evalua...

Inflammation-Responsive NO-Scavenging and CO-Releasing Micelles Alleviate Pulmonary Inflammation and Th2 Cytokine Production in Asthma

Asthma is a heterogeneous and complex disorder characterized by chronic airway inflammation, presenting significant therapeutic challenges. Nitric oxide (NO) and carbon monoxide (CO) serve as pivotal gaseous signaling molecules, with elevated NO levels linked to disease exacerbat...

Development and external validation of a nomogram for overall survival in oral tongue squamous cell carcinoma using machine learning-assisted feature selection

This study aimed to identify prognostic factors using machine learning-assisted feature selection and develop a Cox-based nomogram for predicting 2-year and 5-year overall survival in Oral Tongue Squamous Cell Carcinoma (OTSCC). Clinical data from 5746 OTSCC patients in the SEER...

Application of the ultrasonic oscillation flotation method in paraffin section preparation.

OBJECTIVE: To enhance the quality and efficiency of paraffin-embedded pathological section preparation, this study aims to investigate the potential benefits of utilizing the ultrasound oscillation flotation method (UOFM) for section spreading. METHODS: Specimens of various tissu...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...