Federal Medical-Biological Agency

Approaches to the Development and Quality Control of Vaccine for Allergen-Specific Immunotherapy of Ragweed Pollen Allergy

Ragweed (Ambrosia artemisiifolia) pollen allergy is a major and growing public health problem worldwide, with clinical manifestations ranging from rhinitis and conjunctivitis to asthmatic episodes and anaphylaxis. The major ragweed allergen, Amb a 1, exhibits high IgE-binding pot...

Prevention of anastomotic leakage in esophagogastroplasty (anatomical, experimental and clinical study)

Background. Anastomotic leakage after esophagogastroplasty is a severe complication attributed to insufficient conduit length and ischemia of its proximal segment. A method combining graft lengthening and perfusion improvement without microsurgical intervention is needed. Materia...

Neural Network-Based System for Rapid Diagnostic Decision Support Using FLIM Data: Segmentation and Classification in Liver, Skin, and Pancreatic Tissues

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool for analyzing metabolic changes by measuring the fluorescence lifetime of endogenous fluorophores such as the reduced form of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), enabling differentiation betwe...

Synthesis, Cytotoxicity and Antimicrobial Action of 11 Analogs of Nifuroxazide

The global spread of multidrug-resistant bacteria, alongside the rising burden of oncological diseases, poses an increasing threat to human health and public healthcare systems worldwide. Substantial efforts are underway to discover new drugs and to reposition or repurpose existi...

Semi-occluded vocal tract exercises improvement in patients after laryngeal and hypopharyngeal cancer treatment

INTRODUCTION: The internal and external head and neck lymphedema is one of the consequences of surgical and radiation treatment of laryngopharyngeal cancer. The current task is to develop lymphatic drainage techniques that are effective for internal lymphedema. OBJECTIVE: To eval...

The high bulb of the internal jugular vein in otosurgery: a literature review

Knowledge of the anatomical features of the structures of the temporal bone is important in the practice of an otosurgeon. Nevertheless, information on the high bulb of the internal jugular vein is extremely scarce in the available medical literature. The search and analysis of m...

Modern approaches to the treatment of NCMT sexually transmitted infections (N. gonorrhoeae, C. trachomatis, M. genitalium, T. vaginalis). Part II. M. Genitalium

An analysis of literature data on modern approaches to the treatment of infection caused by M. Genitalium is presented. As for now, it is not included in the list of reportable infections both in most countries of the world and in the Russian Federation, but, according to various...

Machine Learning-Assisted SHG Morphometry Reveals Distinct Collagen Microarchitectures of Trabecular Bone and Fibrosis in Bone Marrow Biopsies

Abstract Collagen microarchitecture in bone marrow biopsies represents a largely underexplored source of quantitative biomarkers for histopathological diagnostics and analysis of tissue remodeling. While second harmonic generation (SHG) microscopy has been increasingly applied to...

Glaucoma and age-related macular degeneration: challenges and prospects for prevention and treatment of combined pathology. Part 1. Epidemiology and pathogenesis

Glaucoma and age-related macular degeneration are the leading causes of irreversible vision loss in individuals over 60 years of age. This review consolidates current data on the epidemiology, shared genetic factors, and pathophysiological mechanisms underpinning their coexistenc...

Laser-Generated Ultrashort Pulsed Electron Beams Induce p53-Related Alteration of DNA Repair and Cell Death Pathways in Non-Small Cell Lung Cancer Cells

Laser-driven accelerated particle beams have significantly advanced cancer treatment by facilitating the delivery of exceptionally high dose rates of radiation to solid tumors within femto- to picosecond timescales. This investigation compared the radiobiological effectiveness of...