Evolutionary Genomics (United States)

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who presented with axonal neuropathy, and assess functional consequences in vitro. Method In this retrospective, multicentre, observational study, we identified 10 individuals from s...

Terrestrial paleoenvironments and paleoclimate during the Miocene climate optimum at Buluk, East Turkana, Kenya

Understanding the environmental and climatic context of Neogene fossil localities in eastern Africa is critical for determining potential drivers of evolution in our hominoid ancestors and their floral and faunal communities. In this study, we reconstructed paleoenvironments and...

Rapidly evolving aphid gall effector proteins exhibit saposin-like folds

Abstract Many insects manipulate plants by injecting effector proteins. In one extreme example of this molecular “hijacking”, Hormaphis cornu aphids inject bicycle proteins into Hamamelis virginiana , contributing to the development of novel organs called galls. Bicycle proteins...

Laboratory and wild Drosophila sechellia have conserved niche specialization phenotypes

Abstract Many studies investigating the proximate causes of evolutionary adaptations dissect potentially adaptive phenotypes under laboratory conditions where organisms are more easily experimentally manipulated. For such models, it remains unclear if organisms maintained long-te...

lncRNAs contribute to caste differentiation as a regulatory layer in ants

Abstract Caste differentiation in ants represents one of the major evolutionary transitions and provides a unique model for studying developmental mechanisms underlying division of labor. Genetically identical individuals follow divergent epigenetically-regulated developmental tr...

The chromosomal genome sequence of a peltospirid gastropod, Rhynchopelta concentrica McLean, 1989 (Neomphalida: Peltospiridae) and its associated microbial metagenome sequences

<ns5:p> We present a genome assembly from a specimen of <ns5:italic>Rhynchopelta concentrica</ns5:italic> (peltospirid gastropod; Mollusca; Gastropoda; Neomphalida; Peltospiridae). The genome sequence has a total length of 716.07 megabases. Most of the assembly (92.08%) is scaffo...