European Molecular Biology Laboratory

The limits of scaling in aggregation-driven patterning of cell collectives

Abstract Robust development requires maintaining correct proportions as overall size varies. What controls and limits this scaling remains poorly understood due to the complex interplay of mechanical and biochemical embryonic factors. Combining confinement of dissociated embryoni...

The gene-regulatory evolution of the human skeleton

Abstract Skeletal modifications were central to human evolution, enabling adaptations for bipedalism, large cranial vaults and childbirth 1 . Despite their importance, the genetic changes that gave rise to the unique human form remain mostly unknown 2 . Here we systematically map...

Self-organization of vascularized muscle from bovine embryonic stem cells

Abstract Cultured beef offers a promising alternative to traditional meat. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. Current manufacturing processes for cultured beef steaks often...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...