École Polytechnique Fédérale de Lausanne

A validated amplicon panel for parentage reconstruction and selection monitoring in whitefish (Coregonus spp.)

Abstract Fish populations are notoriously difficult to monitor because their aquatic habitats limit observation. While physical or chemical tagging (e.g., adipose fin removal or Alizarin Red S staining of bones) can reduce growth or survival or requires sacrifice, genetic tools o...

Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping

Analyses routinely conducted in both fundamental research and biomedical studies often report aggregate signals derived from heterogeneous mixtures of cells. These mixtures reflect the intrinsic anatomical and functional complexity of the tissues and organs from which they are de...

VASP cooperates with zyxin to organize mechanically competent adhesions

Abstract Focal adhesions (FAs) are dynamic macromolecular assemblies that anchor the actin cytoskeleton to the extracellular matrix via integrin receptors, thereby regulating cell morphology and migration. Here, we show that the vasodilator-stimulated phosphoprotein (VASP) cooper...

Efficient Nonequilibrium Electron Dynamics from First-Principles: Leveraging Koopmans Spectral Functionals and Wannier Localization

Abstract We present an efficient first-principles approach for simulating the nonequilibrium electron dynamics in extended systems beyond the linear regime. The method combines Koopmans-compliant functionals, which provide accurate quasiparticle band structures, with the real-tim...

Escalating competition in changing seas: baleen whales exploit killer whale prey herding

Abstract Climate change and other anthropogenic pressures are rapidly reshaping marine ecosystems, altering prey availability and predator interactions. Yet empirical evidence of how these relationships shift under changing conditions remains scarce. Drawing on over a decade of m...

Deterministic generation and distribution of genuine multipartite entanglement in macroscopic acoustic resonators

Generating complex multimode entanglement is a central goal of quantum information science. However, scalable creation of genuine multipartite entanglement is challenging as it requires excellent control and efficient state verification. We report the generation and transfer of g...

Seeing Inside a Plasmonic Nanogap: Few-Molecule Orientation and Preferential Adsorption

Abstract Molecule–surface interactions are central to many research and technological areas, spanning from heterogeneous catalysis and polymer science to electrochemistry. Of particular relevance are metallic nanogaps used in molecular electronics and near-field spectroscopy. Due...

Conformal data for the $O(2)$ Wilson-Fisher CFT in $(2+1)$-dimensional spacetime from exact diagonalization and matrix product states on the fuzzy sphere

We study at zero temperature a microscopic quantum spin-1 model on the fuzzy sphere that realizes the O(2) O ( 2 ) Wilson-Fisher conformal field theory (CFT) in (2+1) ( 2 + 1 ) -dimensional spacetime at a quantum critical point. Here, we use the fuzzy-sphere regularization as it...

Antivirulence Benzothiophenes Inhibit Intracellular Mycobacterium tuberculosis by Targeting the Sensor Histidine Kinase MprB

Abstract Pulmonary tuberculosis remains one of the most prevalent and threatening infectious diseases. Classical anti-tubercular therapy targets essential enzymes of the pathogen Mycobacterium tuberculosis (Mtb), thereby suppressing bacterial growth. However, the emergence of dru...

Using large language models to probe the limits of atom-centered structural descriptors

Mapping an atomic structure to a compact set of geometric descriptors is an essential step in any machine-learning application to atomic-scale modeling. A powerful and widely used approach can be understood as a discretization of the histogram of pair distances, triangles, etc.,...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

Dispersal diversity buffers species vulnerability to local extinction

Abstract Predicting species persistence within ecological communities is a fundamental challenge for both empirical and theoretical ecology. Existing methods span from mechanistic models, whose parameters are difficult to estimate from data, to statistical tools whose context-spe...

Dopaminergic state modulates shame and contextual emotional responses in Parkinson's disease

Background Shame is frequent in Parkinson's disease (PD) and negatively affects quality of life, yet its dopaminergic modulation remains unclear. Methods We investigated the effect of dopaminergic replacement therapy (DRT) on shame in 41 fluctuating PD patients using an experimen...

Prefabrication of structural walls from large mineral rubble

Abstract This paper presents a new, low-carbon prefabrication process for load-bearing structural walls. It reuses large flat concrete and stone rubble sourced from demolition waste, is readily scalable, and operates under controlled factory conditions, combining the structural l...

Irregularly and incompletely sampled random fields in the Earth sciences: Analysis and synthesis of parameterized covariance models

Summary Geophysical data observed in the Earth, planetary, and lunar sciences are spatially limited to sampling plans designed to span a feature of interest whose resolution and regularity in discretization are bound by site, observational, and instrumental constraints. Common wi...

Evaluating sustainable mobility potential through geographical accessibility and individual access, skills and appropriation

The 15-min city concept promotes accessibility to opportunities notably by encouraging the use of sustainable modes of transport for daily mobility. However, it may not be enough just to provide activities that are accessible via public transport (PT) within 15 minutes if individ...

Reconciling intrinsic and ecosystem water-use efficiency reveals physiological mechanisms underlying carbon-water coupling across biological scales

Understanding how carbon-water coupling scales from leaves to ecosystems remains a major challenge because water-use efficiency (WUE) metrics integrate physiological, hydrological, and ecological processes. We integrated tree-ring width, triple stable isotopes (δ13C, δ18O and δ2H...

Characteristics of monotonic sheaths near a wall with grazing magnetic incidence

Abstract We consider a magnetised plasma in contact with an absorbing planar wall, where the angle α between the magnetic field and the wall is small, α ≪ 1 (in radians), and the plasma is uniform in the directions tangential to the wall. The finite ratio γ of the characteristic...

Latent causal diffusions for single-cell perturbation modeling

Perturbation screens hold the potential to systematically map regulatory processes at single-cell resolution, yet modeling and predicting transcriptome-wide responses to perturbations remains a major computational challenge. Existing methods often underperform simple baselines, f...

Enhancing Stability of Layered Double Perovskites With a Naphthalene Diimide Spacer Toward Photoelectrochemical Application

ABSTRACT Lead‐free layered hybrid double perovskites (LHDPs) promise stable, non‐toxic optoelectronic devices, but operating these materials in applications with a direct semiconductor/water interface remains a challenge. We show that a bulky, hydrophobic naphthalene diimide dica...