École Normale Supérieure de Lyon

Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France

“Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus...

The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

ABSTRACT In flowering plants, floral organ identity is specified by the combinatorial action of homeotic genes. While the role of these genes in the early specification of organ identity is well established, their late function throughout floral organ development and in specific...

Deciphering Aggregation-Induced Tunable Circular Dichroism of AuBP@Ag and AuBP@Au Chiral Core–Shell Plasmonic Nanoparticles

Abstract Plasmonic nanoparticles exhibiting strong and tunable chiroptical signals have been drawing much interest recently due to their potential vast applications. A few years ago, it was shown that seed-mediated metal growth can be harnessed to make single nanoparticles intrin...

The Dynamics of the Racial Wealth Gap

ABSTRACT We study the dynamics of the racial wealth gap (the wealth of Black households relative to white ones) using a dynamic equilibrium model of overlapping generations. We match the model to the cross‐sectional distributions of wealth and earnings by race. We find that equal...

Gene-rich fungus gnat germline-restricted chromosomes are largely transcriptionally quiescent

Germline-restricted chromosomes (GRCs) constitute a unique class of chromosomes confined to germ cells. Arising in multiple evolutionarily distant lineages, GRCs have been identified in three insect families (non-biting midges, gall midges, and fungus gnats), each within the orde...

Unified toolbox for multipartite entanglement certification

We present a unified framework for multipartite entanglement characterization based on the conditional gradient (CG) method, incorporating both fast heuristic detection and rigorous witness construction with numerical error control. Our method enables entanglement certification i...

Pure Shift 2D NMR with Water Suppression for Structural and Dynamic Analysis of Flexible Molecules

Abstract Achieving high-resolution proton NMR spectra in aqueous media remains a major challenge for structurally complex and conformationally flexible molecules, where homonuclear scalar couplings and limited chemical-shift dispersion lead to severe spectral congestion. Here, we...

Temperature sensitivity of snow viscoplasticity: Evidence from controlled creep experiments

Abstract. Snow is a warm, porous material whose densification under its own weight is highly temperature-dependent. Despite decades of research, reported activation energies for snow viscoplasticity remain highly scattered, ranging from 40 to 600 kJ mol-1. We quantified the tempe...

Superinfection exclusion strategy of siphophage T5: analysis of the FhuA:Llp complex

ABSTRACT Superinfection exclusion is a widespread viral mechanism that protects the infected cell from overinfection by other identical or closely related viruses. Shortly after infection by bacteriophage T5, the bacterium Escherichia coli produces Llp, encoded by the newly injec...

Unraveling Vulnerabilities and Pathways Responsible for AITL Malignancy to Improve Patients’ Treatment

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma characterized by poor clinical outcomes following conventional CHOP-based chemotherapy and the lack of effective disease-specific therapeutic options. The disease finds its origin in...

Weak Anion Hydration Drives LCST Behavior in Ionic Liquid–Water Mixtures: Insights from Calorimetry and Neutron Diffraction

Abstract Isothermal titration calorimetry (ITC) combined with neutron diffraction and isotopic substitution (NDIS) has been used to elucidate the molecular origins of lower critical solution temperature (LCST) behavior in the tetrabutylphosphonium 5-phenyltetrazolate/water ([P444...

Towards an Instagram research methodology for geotagged data: Theoretical and qualitative perspectives for multimodality studies

Instagram research has expanded rapidly across sociolinguistics and social semiotics, yet few replicable models exist for conducting robust analyses of its data. In this vein, I propose a qualitative approach to Instagram research that foregrounds the role of platform affordances...

A Formalization of the Ionescu-Tulcea Theorem in Mathlib

Schröer et al. [Philipp Schröer et al., 2023] developed a verification infrastructure for rapid prototyping of automated verification techniques for probabilistic programs (PPs), which is based on the quantitative intermediate verification language HeyVL. In a nutshell, users enc...

Sensitive reverse transcription-digital droplet PCR-based discrimination of hepatitis delta virus RNAs reveals differential effects of interferon-α on viral RNA species

Hepatitis delta virus (HDV) replication relies on the production of distinct viral RNA species, including genomic (HDV-G), antigenomic (HDV-AG) and mRNAs (HDV mRNAs), which differ in abundance and function. However, the lack of sensitive and quantitative approaches allowing their...

Memory on ice: spatial memory is retained over a 9-month hibernation period in Columbian ground squirrels

Abstract Memory allows animals to utilize ecologically relevant information, yet whether it endures through prolonged metabolic shutdown is poorly understood. We tested spatial memory retention in a long-term, free-living hibernator, the Columbian ground squirrel (Urocitellus col...

Assessment of infection prevention practices in office-based surgery: a multicentre regional audit

Abstract Background Office-based surgery (OBS) is increasingly used due to organizational constraints and perceived benefits. However, data on infection prevention and control (IPC) practices in OBS settings remain limited. This study aimed to assess the conditions in which OBS a...

Fault-tolerance Strategies for Linear Chains of Moldable Tasks

This work considers fault-tolerant strategies to protect linear chains of moldable tasks from fail-stop errors, or from silent errors, or from both. To the best of our knowledge, the study of linear chains of moldable tasks on error-prone platforms has never been tackled, despite...

Sensitivity of neutrino oscillations to the Earth’s interior properties

Understanding the Earth’s deep interior remains challenging, as traditional geophysical methods face ambiguities in linking seismic observations to temperature, composition, or mass density variations. Atmospheric neutrinos, produced by the constant flux of cosmic rays colliding...

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are widely used to image intracellular environments. Here we report donor–acceptor dyads based on the BODIPY chromophore in which PET is selectively activated upon hydration. Replacing fluorine groups at bo...

What Drives the Selectivity of 5-(Hydroxymethyl)furfural Electroreduction over Copper in Mildly Basic Medium?

Abstract 2,5-Bishydroxymethylfuran (BHMF) is an important bio-based monomer that can be produced via the electrochemical reduction of 5-(hydroxymethyl)furfural (HMF) on Cu electrocatalysts. Under mildly alkaline conditions, however, BHMF formation competes with hydrodimerization...