East Carolina University

HMGB1 andHMGB2 Are O 4-Alkylthymidine-BindingProteins

Abstract Exposure to endogenous and exogenous sources of alkylating agents leads to DNA lesions that can impair cell survival and confer genome instability by eliciting mutations during DNA replication and transcription. Among the DNA alkylation adducts, O4-alkylthymidine (O4-alk...

Pharmacokinetic and pharmacodynamic sub-study of trans-arterial vs. intravenous gemcitabine in the TIGeR-PaC phase 3 clinical trial

Abstract Purpose Localized intra-arterial delivery of gemcitabine (IAG) may provide advantages in terms of increased tissue concentration and decreased systemic dosing. We hypothesized IAG may result in decreased systemic gemcitabine concentration and associated side effects due...

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Female gametogenesis in Drosophila melanogaster requires differentiation and mitotic division of germ cells, acquisition of oocyte fate, and entry into meiosis. Each of these processes is well understood individually; however, little is known about the mechanisms that ensure prop...