Düsseldorf University Hospital

Maintained critical flicker fusion frequency after acute hyperbaric hyperoxia at 140 kPa

Introduction: In diving medicine, critical flicker fusion frequency (cFFF) has been employed to assess alertness under varying ambient pressures and gas compositions, yet the effects of elevated oxygen partial pressure on cFFF performance underwater remain inconsistently characte...

Adaptations to breath-hold diving: from traditional divers to elite athletes

Breath-hold diving exposes humans to repeated episodes of profound hypoxia and hypercapnia, eliciting physiological adaptations that enable prolonged underwater performance. This article summarises current knowledge on chronic adaptations in elite breath-hold athletes and traditi...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Exploring spatial heterogeneity of PD-L1 and c-MET expression in oral squamous cell carcinoma

Abstract Background PD-L1 expression is an established predictive biomarker for immune checkpoint inhibitor therapy in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC). However, the spatial heterogeneity of PD-L1...

Dissection of superficial temporal artery for STA-M4 bypass, an integrated method. How I do it

BACKGROUND: Extracranial-intracranial (EC-IC) bypass is an effective revascularization technique for flow augmentation in conditions including Moyamoya disease and ischemic cerebrovascular disorders. Preparation of donor vessel is a key step for EC-IC Bypass surgery. This procedu...

Comparative Pharmacokinetics of Trientine Dihydrochloride Capsules: A Randomized, Open-Label, Reference-Controlled, Two-Period Crossover Study in Healthy Volunteers

Trientine dihydrochloride (TETA-2HCl) is an oral copper chelator used for Wilson disease. Because available formulations differ in marketed strength and may have formulation-specific pharmacokinetic properties, this study compared a 250 mg test capsule and a 300 mg reference caps...

Comparison of High‐Sensitivity Troponin T Versus N‐Terminal Pro‐B‐Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery

Background Preoperative hs‐TnT (high‐sensitivity cardiac troponin T) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for risk prediction in noncardiac surgery. While the European Society of Cardiology recommends hs‐TnT, American Cardiology and European anesthes...

Associations of leisure time and occupational physical activity with tobacco smoking and dual use of e-cigarettes among adults – a representative cross-sectional survey in Germany

Abstract Background Physical inactivity and tobacco smoking are risk factors for chronic diseases, and the combination of both further increase health risks. While leisure time physical activity (LTPA) improves cardiovascular health and is associated with lower smoking prevalence...

Effectiveness of an on-site vaccination campaign for patients with cancer

Abstract Background Patients with haematological or oncological malignancies are at increased risk of severe infections. Vaccination is a key preventive strategy and is recommended by National Immunization Technical Advisory Groups (NITAGs). Yet, vaccination rates in this populat...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

A multicenter analysis of prognostic factors for patients undergoing re-irradiation for recurrent glioblastoma

Abstract Background Re-irradiation (re-RT) has gained popularity in the treatment of recurrent or progressive glioblastoma (rGBM) after first-line treatment. However, uncertainties regarding optimal treatment dose, fraction size and target volume definition remain. In this multic...

Designing a School-Based, Complex Public Health Intervention to Improve Iodine Awareness in Adolescents in Six Countries

Background: Iodine is an essential micronutrient required for foetal development, cognitive function, and metabolic regulation; however, suboptimal iodine status remains a public health concern in Europe and other regions. Improving food literacy related to iodine may support hea...

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largel...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

Can parent–child interactions help reduce socioeconomic differences in language development? Results of a German birth cohort study

Abstract Aim Children from socioeconomically disadvantaged families often have lower developmental outcomes than their socioeconomically more advantaged peers. In early childhood, language development (LD) in particular is a key competence for further socialization. There is a ne...

The liver in diabetes: current state and future perspectives

Abstract Diabetes mellitus is strongly associated with metabolic dysfunction-associated steatotic liver disease (MASLD). For many years, MASLD has not been recognised as either a common pathophysiological feature of type 2 diabetes or a diabetes-related complication. This special...

Cardiac Opioid System and Its Role in Heart Failure and Ischemia–Reperfusion Injury

Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained increasing attention for its potential role in cardiovascular disease and perio...

Influence of dextran deswelling on graft preparation and clinical outcomes in DMEK

Abstract To evaluate the influence of dextran-containing versus dextran-free organ culture media on graft preparation characteristics and postoperative outcomes following Descemet Membrane Endothelial Keratoplasty (DMEK). In this single-center retrospective comparative study, 31...