Duke Medical Center

Deletion of P311 enhances regeneration in aged skeletal muscle

While aging results in marked decreases in the capacity of skeletal muscle to repair following injury, as well as increases in fibrosis, the pathways and factors that regulate these processes are poorly defined. P311/Nrep (P311) is a highly conserved protein known to promote fibr...

Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women

BACKGROUND: The D3-creatine (D3Cr) dilution method provides a non-invasive and accurate assessment of muscle mass. Our objective was to examine the relationship between D3Cr muscle mass, objective measures of physical performance, and self-report physical function postmenopausal...

Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals

Abstract Objective To evaluate the management practices of Infantile Epileptic Spasms Syndrome (IESS) across tertiary pediatric hospitals in the United States using a survey‐based approach. Methods A 21‐question survey focused on management setting, work‐up, follow‐up and treatme...

“She cannot use these methods before she has at least one child”: a qualitative study on family planning attitudes, knowledge, and experiences among adolescent girls and young women living with HIV in Moshi, Tanzania

Abstract Background Each year, about half of pregnancies in adolescents (15–19 years of age) are unintended, and the rate of adolescent pregnancy in sub-Saharan Africa is twice the global rate. Adolescent pregnancies have similar social determinants as those of HIV acquisition, r...

Activation of the angiotensin II type I receptor by a nonpeptide agonist

The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the most successful pharmacological targets for the treatment of hypertension. Within the angiotensin receptor pharmacological landscape, a...

Assessment of left atrial native T1 values using non-contrast 3.0 T cardiac magnetic resonance imaging: a feasibility and reproducibility study

Atrial cardiomyopathy (ATC) is characterized by structural and functional atrial remodeling and is associated with adverse cardiovascular outcomes. Native T1 mapping has emerged as a sensitive technique for tissue characterization; however, data on left atrial (LA) native T1 mapp...

The pharmacogGENEtics in Youth Depression (GENE-YD) study for personalizing antidepressant pharmacotherapy for young Western Australians – A feasibility study

Abstract Pharmacogenetic (PGx) testing to guide antidepressant prescribing is becoming increasingly available. However, its uptake into routine psychiatric practice for young people remains limited due to insufficient youth-specific evidence and uncertainty regarding optimal tria...