Drexel University

Impact of timing on outcomes following redo-sternotomy after initial CABG or valvular surgery

The optimal timing of reoperation for those who need repeat coronary artery bypass grafting (CABG) and valve surgery is not well established. Early re-entries may be technically challenging due to adhesions and incomplete healing, while delayed interventions may expose patients t...

Extreme Risk Protection Order laws and fatal violence against women: a quasi-experimental study

Background Rates of intimate partner homicides of women in the USA are high relative to other high-income countries, especially those involving firearms. We evaluated one potential policy solution by examining state Extreme Risk Protection Order (ERPO) firearm transfer laws and i...

Oropharyngeal Lateral Wall Collapse as a Predictor of Hypoglossal Nerve Stimulation Response: A Systematic Review and Meta-Analysis

Purpose Oropharyngeal lateral wall collapse (OPLW) on drug-induced sleep endoscopy (DISE) may influence outcomes after hypoglossal nerve stimulation (HNS) for obstructive sleep apnea (OSA). This systematic review and meta-analysis evaluates whether DISE-defined OPLW collapse is a...

Human spinal interneurons repair the injured rat spinal cord through synaptic integration

Spinal cord injury (SCI) results in irreversible disruption of motor, sensory, and autonomic circuits with no approved reparative treatment to restore lost function. Endogenous V2a spinal interneurons (SpINs) have been implicated as a key component in recovery post-SCI, but the i...

Delayed methotrexate toxicity after initial clearance in a critically ill patient with severe fluid overload

Methotrexate (MTX) toxicity is a life-threatening complication in oncology patients. We report a 19-year-old male with newly diagnosed Burkitt lymphoma who received high-dose methotrexate as part of induction chemotherapy and initially met protocol-defined serum clearance criteri...