Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi

FOLFOX Plus Bevacizumab Rechallenge Versus Regorafenib as Third-Line Treatment in Metastatic Colorectal Cancer: The Role of the Oxaliplatin-Free Interval

Background: The optimal use of chemotherapy rechallenge in later-line metastatic colorectal cancer (mCRC) remains uncertain. We compared third-line FOLFOX plus bevacizumab rechallenge with regorafenib and examined whether the oxaliplatin-free interval was associated with treatmen...

Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study

Background and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Although lymphopenia is a well-recognized pharmacological effect, its clinical significance remains uncer...

Large Language Models in Perioperative Antithrombotic Management: A Blinded Scenario-Based Expert Evaluation

Background: Perioperative antithrombotic management is a complex and high-risk aspect of anesthesia practice, requiring a careful balance between bleeding and thromboembolic risks. Large language models (LLMs) are increasingly explored for clinical decision support, but their rel...

Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis

Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with a relapsing course. The neutrophil-to-lymphocyte ratio (NLR) has been investigated as a potential inflammatory biomarker in various diseases. This study aimed to evaluate the association be...

Prevalence and prognostic significance of obstructive sleep apnea in patients with idiopathic pulmonary fibrosis: A prospective cohort study

ABSTRACT BACKGROUND: Obstructive sleep apnea (OSA) is a recognized comorbidity in idiopathic pulmonary fibrosis (IPF); however, its true prevalence remains uncertain, and its prognostic implications have not been fully elucidated. This study aimed to determine the prevalence of a...

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment pa...

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion–induced pressure ulcer model, a pilot exploratory animal study

Objectives: This study aimed to determine the messenger ribonucleic acid (mRNA) expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-17, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) -5 in an acute ischemia/reperfusion (I/R)-induced pressure ulc...

Problematic Smartphone Use in Parkinson’s Disease: Associations with Mood, Non-Motor Burden, and Impulsivity

Objective: To investigate problematic smartphone use and its associations with mood symptoms, impulsivity, and non-motor symptom burden in Parkinson's disease (PD). Methods: Forty-five patients with PD younger than 60 years and 43 matched healthy controls completed the Smartphone...

Etelcalcetide Versus Cinacalcet for Secondary Hyperparathyroidism in Hemodialysis Patients: A Multicentre Comparison with 24 Months of Follow-Up

Background/Objectives: Secondary hyperparathyroidism (SHPT) is a prevalent complication of end-stage kidney disease. Although etelcalcetide has demonstrated short-term superiority over cinacalcet in randomized trials, real-world comparative data beyond 12 months remain scarce. Th...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...

Postoperative subclinical nerve injury after closed reduction and percutaneous pinning of paediatric supracondylar humerus fractures: a prospective Electromyographic study

OBJECTİVES: To detect early postoperative subclinical nerve injury in pediatric supracondylar humerus fractures and to identify associated risk factors. METHODS: Design : Prospective cohort study Setting: Single Level 1 trauma center Patient selection criteria: Patients aged 1–12...

Association between lateral lobe enucleation time and urethral stricture after Holmium Laser Enucleation of the Prostate (HoLEP): a retrospective cohort study

To evaluate whether lateral lobe enucleation time is associated with postoperative urethral stricture after holmium laser enucleation of the prostate (HoLEP). We retrospectively reviewed 519 HoLEP procedures performed between January 2023 and January 2025. To minimize operator- a...

Incidence and risk factors of incisional hernia after CRS and HIPEC for colorectal-appendiceal peritoneal malignancies: a retrospective cohort study

Abstract Background Incisional hernia is a common late complication after extensive abdominal surgery and may significantly impair quality of life. The incidence and risk factors of incisional hernia in patients undergoing cytoreductive surgery (CRS) combined with hyperthermic in...