Dokkyo Medical University

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Visible reasoning: turning AI consultation into diagnostic learning

AI consultation is now common in diagnostic work, but it is still judged mainly by whether it improves the immediate answer. In this paper, I propose that AI consultation can also support clinician learning when the clinician's diagnostic judgment and the AI response are recorded...

Impact of third-party accreditation and general medicine in-training examination participation on residency program popularity: a nationwide matching data analysis in Japan

Abstract Background Third-party accreditation and the visibility of educational outcomes may influence medical students’ choice of training sites; however, national evidence of their effect in Japan is limited. This study examined whether hospital characteristics—especially Japan...

Robotic pancreatoduodenectomy attenuates perianastomotic exudative changes and reduces pancreatic fistula in patients with low-grade malignancies: a retrospective cohort study

To compare the short-term outcomes of robotic pancreatoduodenectomy (RPD) and open pancreatoduodenectomy (OPD) in patients with low-grade malignancies, focusing on perianastomotic CT findings and pancreatic fistula. Ninety-four patients who underwent PD with pancreatojejunostomy...

“Learning bystander activation”: resident-led diagnostic error case conferences and sustained reflective engagement among junior residents

OBJECTIVES: Diagnostic errors are a major patient safety concern, particularly in emergency settings where junior residents frequently perform initial evaluations. Diagnostic error case conferences are used as educational interventions, but their impact on sustained learning beha...

Histological Prostatic Inflammation Is Associated With Storage Lower Urinary Tract Symptoms and Inflammatory/Fibrotic Marker Expression in Benign Prostate Biopsies

ABSTRACT Background Chronic histological inflammation is frequently observed in benign prostate tissue; however, its clinical significance and biological relationship with lower urinary tract symptoms (LUTS) remain incompletely understood. We investigated whether histological inf...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

Individualized Opioid Titration for Complex Symptom Management in Terminally Ill Cancer Patients Receiving Home Hospice Care: A Prospective Cohort Study

Background Individualized opioid titration is recommended for symptom management in patients with advanced cancer, but prospective data from home hospice care remain limited. We evaluated individualized opioid titration in terminally ill cancer patients receiving physician-led ho...

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

Perioperative Cognitive Decline in Verbal Associative Memory Following Carotid Revascularization and Subsequent Risk of Adverse Events: Clinical Significance of the Standard Verbal Paired Associate Learning Test (S-PA)

Background/Objectives: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing...

Executive summary of the Japanese clinical practice guidelines for tuberous sclerosis complex-associated epilepsy 2025

Purpose Tuberous sclerosis complex (TSC)-associated epilepsy often involves focal epilepsy, infantile epileptic spasms syndrome (IESS), and drug-resistant epilepsy (DRE). This article presents an executive summary of the Japanese Clinical Practice Guidelines for Tuberous Sclerosi...

A Novel Biliary Plastic Stent With a Centrally Located Flap: Initial Clinical Experience in Three Cases

ABSTRACT Endoscopic biliary plastic stent (PS) insertion is standard for maintaining bile flow, but migration and dislodgement persist as important challenges. We developed the cross range flap stent (CRF stent), a 7 Fr, 7 cm straight‐type PS. Unlike conventional stents with flap...

A Case of Tracheal Stent Placement under Extracorporeal Membrane Oxygenation for Airway Stenosis Caused by Subcarinal Lymph Node Metastasis from Muscle-Invasive Bladder Cancer

症例は64歳，女性。泌尿器科にて筋層浸潤性膀胱癌の治療後で，当科で非結核性抗酸菌症にて通院中であった。経過中に湿性咳嗽と喘鳴があり，吸入ステロイド薬/長時間作用性β2刺激薬配合剤およびステロイド点滴投与を行った。しかし呼吸困難感が増強し胸部CTを撮影したところ，径30 mmの気管分岐部リンパ...