Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Screening for multidrug-resistant organism: clinical benefit or unquestioned routine

PURPOSE OF REVIEW: Current strategies for multidrug-resistant organism (MDRO) screening are primarily intended to support infection prevention programs. However, accumulating evidence indicates that intestinal colonization also provides clinically relevant information for antimic...

Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and Meta‐Analysis

Background To date, >10 million children have been conceived via assisted reproductive technology (ART) globally. However, there are some concerns about potential adverse outcomes associated with ART‐conceived pregnancies, including the risk of congenital heart defects (CHDs). Th...

Targeted DNA Sequencing Reveals Distinct Rare-Variant Profiles in Pulmonary Hypertension Associated with Chronic Lung Diseases

The mechanisms underlying the development and severity of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) remain poorly understood. To investigate the contribution of genetic factors, we performed targeted sequencing...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Comparative analysis of maternal diet and its individual compounds in pregnancies with and without preeclampsia

Maternal diet during pregnancy may influence maternofoetal outcomes, including the occurrence of preeclampsia. The objective was to assess the association of maternal adherence to a Mediterranean diet pattern with preeclampsia, and the correlation with surrogate makers of the dis...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

N-Acetylcysteine in Schizophrenia: A Convergent Redox-Based Approach to Therapeutic Potential

Schizophrenia (SCZ) remains one of the most disabling psychiatric disorders, in large part because current antipsychotics (APs) inadequately address negative symptoms and cognitive deficits. Converging evidence implicates a set of interconnected mechanisms, NMDAR hypofunction, ox...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Mental health disparities in LGBTQIA+ populations: an umbrella review of systematic reviews and meta-analyses.

Lesbian, gay, bisexual, transgender, questioning, intersex, asexual (LGBTQIA+) populations face unique social, political, psychological and health care-related challenges that contribute to marked mental health disparities. However, the overall strength and credibility of evidenc...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives

Background/Objectives: Schizophrenia is a chronic psychiatric disorder traditionally associated with early adulthood; however, an increasing number of individuals are now reaching older age, highlighting the need to better understand the aging process in this population. Emerging...

Anatomical Determinants of the Left Atrial Electrograms: Wall Thickness and Myocardial Fat Infiltration

INTRODUCTION: Electrogram peak-to-peak voltage depends on atrial wall structure and mapping configuration. We evaluated the relationship between computed tomography-derived atrial wall thickness, intramyocardial fat, myocardial muscle thickness, and electrogram voltage obtained w...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Use of Oxygen in the Emergency Department

ABSTRACT Oxygen is one of the most frequently used treatments in the emergency department (ED), but it should be prescribed and reassessed as an active therapy rather than left as a harmless default. Acute hypoxemia may reflect ventilation-perfusion mismatch, shunt, hypoventilati...

LINC00152 is a lncRNA modulated by microenvironmental stimuli that has pathogenetic and clinical relevance in CLL

Abstract Chronic lymphocytic leukemia (CLL) is a common lymphoid neoplasm with heterogeneous biological features and clinical behavior, influenced by acquired genetic alterations and microenvironment interactions. We explored non-coding RNAs expression to understand their role in...