Complexo Hospitalar Universitário Professor Edgard Santos

Development of a Single Thermal Cycling Multiplex RT-qPCR Assay for Rapid Arbovirus Detection

Background: The co-circulation of multiple arboviruses with similar clinical presentations poses a significant challenge for public health surveillance. This study aimed to develop and clinically validate a novel multiplex RT-qPCR assay for the simultaneous detection of five arbo...

Emergency physician-modified endograft for ruptured thoracoabdominal aneurysms: Should renal preservation always be pursued?

Fenestrated and branched endovascular devices have expanded the treatment options for complex aortic pathology, and physician-modified endografts (PMEGs) have emerged as a potential alternative for urgent repair. However, an important unresolved question is whether renal artery p...

Prevalence and magnitude of muscle loss in the pediatric intensive care unit assessed by ultrasound: a systematic review and meta-analysis

OBJECTIVE: To systematically review and quantify the variation in quadriceps femoris muscle thickness in children admitted to pediatric intensive care units (PICUs) and to identify factors associated with this loss. METHODS: Searches were performed in Cochrane Library, Embase, Pu...

Gene therapy benefits in a small cohort of symptomatic 5q spinal muscular atrophy patients and real world pediatric outcomes

OBJECTIVE: To characterize clinical outcomes of gene replacement therapy administered after symptom onset in a small group of children with 5q spinal muscular atrophy (SMA) and to describe its impact on motor function and supportive care needs in real-world practice. METHODS: Obs...

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug-induced liver injury (DILI) is still scarce. We aimed to ascertain the incidence, clinical profile, culprit drugs, and prognosis associated with concomitant DILI and AKI. We include patients from two long-...