Institution
Cold Spring Harbor Laboratory
Recent research
- BiologyOpen access
Gaugefixer: overcoming parameter non-identifiability in models of sequence-function relationships
Background: Mathematical models that describe sequence-function relationships are widely used in computational biology. A key challenge when interpreting these models is that their parameters are not uniquely determined, i.e., many different parameter choices can encode the same...
- BiologyOpen access
Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic laboratories. Here, we present the GGB system,...
- BiologyOpen access
A dependency map enhanced with next-generation 3D cancer models
Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...
- BiologyOpen access
A compendium of next-generation patient-derived models for diverse cancers
Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...