Cliniques Universitaires Saint-Luc

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays...

Adrenaline Use and Request for Emergency Medical Assistance to Manage Food Anaphylaxis

Summary Adrenaline was rarely used, medical assistance being requested in two thirds of anaphylaxis cases. Medical assistance request was less frequent if milder or no cardiovascular anaphylaxis symptoms.

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Oligogenic inheritance in epilepsy: A systematic exome‐wide analysis

Abstract Objective Genetic factors contribute to the majority of epilepsies, but the exact genetic cause remains unknown in most patients. Incomplete penetrance and variable expressivity are frequent, and recent studies showed a burden of deleterious variants in epilepsy genes, s...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Scala Tympani Versus Scala Vestibuli Cochlear Implantation in Incomplete Partition Type III Malformation

Incomplete partition type III (IP-III) is a congenital inner ear malformation characterized by a deficient separation between the cochlear modiolus and the internal auditory canal (IAC). In patients with IP-III and severe-to-profound sensorineural hearing loss, cochlear implantat...