Cliniques Universitaires Saint-Luc

Side‐Step Cutting Foot Biomechanics and Intrinsic Foot Muscle Sizes in People With Chronic Ankle Instability

ABSTRACT Introduction Lateral ankle sprains commonly occur during directional changes and often lead to chronic ankle instability (CAI) associated with altered movement patterns, muscle weakness and atrophy. This study aimed to compare foot joint biomechanics during cutting among...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

How I Identify and Diagnose Carriers of Hemophilia and Women and Girls with Hemophilia

Carriers of hemophilia and women and girls with hemophilia remain underdiagnosed despite increasing recognition that they may experience clinically significant bleeding, reduced clotting factor levels, and important reproductive and psychosocial challenges. Advances in coagulatio...

Exploring seismocardiographic signals in children with congenital heart disease: a prospective pilot study

Abstract Congenital heart diseases (CHD) are the most common congenital malformations, and early identification is essential for reducing their morbidity and mortality. This prospective pilot study evaluated the feasibility and exploratory diagnostic relevance of seismocardiograp...

Premedication practices prior to neonatal laryngoscopy: a nationwide observational study in Belgian NICUs

Intubation or less invasive surfactant administration (LISA) in neonates both require laryngoscopy, a stressful and painful procedure. This study aimed to document premedication practices before laryngoscopy in Belgium and explore reasons for absence of premedication. Sub-analysi...

Lobular cancerization in biopsy-diagnosed ductal carcinoma in situ (DCIS) of the breast: a detailed histopathological evaluation and reproducibility study

The role of lobular cancerization in ductal carcinoma in situ (DCIS) of the breast is poorly described to date. A precise definition is lacking. We explored the association between lobular cancerization in biopsy-diagnosed DCIS and different other histopathological features, as w...

Delivering the EU Safe Hearts Plan: the essential role of laboratory medicine in cardiovascular health

Abstract The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, and monitoring across Europe. This EFLM position paper argues that laboratory medicine must be recognized as a central component of its implem...

Antibiotic-Impregnated Bone Grafts in the Masquelet Technique Reduce the Risk of Persistent Infection at Early Follow-up

OBJECTIVES: To compare antibiotic-impregnated composite bone grafts (AIBG) with the standard autologous cancellous bone graft for reconstruction of infected segmental bone defects (ISBD) using the induced membrane technique (IMT). DESIGN: Retrospective study of prospectively coll...

Villous Architecture in Colorectal Adenomas: Molecular Pathogenesis, Epithelial Plasticity, and Malignant Risk

Villous morphology is routinely used to stratify risk in conventional colorectal adenomas, yet it remains largely interpreted as a visual histological descriptor. This review proposes a different view: villous architecture is a graded, spatially organized epithelial state that li...

Focal and Steerable Temporal Interference Stimulation of the Human Left Posterior Insula: A Proof-of-Concept Validation Using Intracranial Recordings in a Human Cadaver

The insular cortex, especially its posterior subdivision, is a key hub for interoceptive, somatosensory, and nociceptive processing, making it a compelling target for neuromodulation. However, its depth within the lateral sulcus makes it difficult to reach selectively with conven...

Why Metrics Matter in Thyroid Eye Disease

Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the clinical me...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Profiling immune check point inhibitors – Induced arthritis: A systematic review and pooled analyses of cohort studies

Background The growing use of immune checkpoint inhibitors (ICIs) in the oncology field along with the potential development of the so-called immune-related adverse events (irAEs) has introduced new diagnostic and therapeutic challenges for rheumatologists. Rheumatic irAEs (Rh-ir...

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...

StereoBed - salvage stereotactic body radiotherapy of the prostate bed for biochemical recurrence after radical prostatectomy: study protocol for a randomized phase II/III trial

In cases of biochemical recurrence (BCR) after radical prostatectomy, salvage radiotherapy (RT) is a well-established standard-of-care treatment. Stereotactic body radiotherapy (SBRT) may offer a shorter treatment duration and favorable radiobiological characteristics, but eviden...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Adrenaline Use and Request for Emergency Medical Assistance to Manage Food Anaphylaxis

Summary Adrenaline was rarely used, medical assistance being requested in two thirds of anaphylaxis cases. Medical assistance request was less frequent if milder or no cardiovascular anaphylaxis symptoms.

Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...