Clinics Hospital of Ribeirão Preto

Optimizing Extraction of Bioactive Compounds from Grape Pomace to Produce an Eco-Friendly Smart Straw

Abstract Grape pomace (GP) is a byproduct rich in bioactive compounds. This study optimized the extraction of these compounds using a Central Composite Rotational Design (CCRD 22), evaluating temperature (41–69 °C) and time (0.8–3.2 h). The optimized extract (GPE) showed high phe...

Allogeneic Hematopoietic Cell Transplantation for Pediatric Unstable Hemoglobinopathies: An Aggregated Cohort with Long-Term Follow-Up from a Brazilian Center

Background/Objectives: Severe unstable hemoglobinopathies may cause transfusion dependence from early childhood, and allogeneic hematopoietic cell transplantation (allo-HCT) is the only established curative option. Pediatric experience with allo-HCT for unstable hemoglobinopathie...

Light stimuli attenuates inflammatory activation in primary bone marrow-derived macrophages

Abstract Bone repair depends on a regulated macrophage-driven inflammatory response. Non-activated macrophages (M0) differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in response to microenvironmental signals. This study evaluated, in vitro, the effects...

Flow cytometry as a tool for assessing reactive oxygen species-related fluorescence in peripheral blood leukocytes from children and adolescents with asthma

Background Asthma is characterized by airway inflammation and bronchial hyperreactivity, with increased production of reactive oxygen species (ROS). Assessing oxidative stress is relevant to disease pathophysiology, but many methods have limitations in pediatric populations . Obj...

Adjunctive mild controlled hypothermia for moderate necrotizing enterocolitis in very low birth weight infants: a prospective cohort study with external contemporaneous controls

Abstract Necrotizing enterocolitis (NEC) is a severe condition in preterm infants. Few therapies are available to slow disease progression or reduce the need for surgery. This study aims to assess if mild controlled hypothermia as an adjunctive treatment reduces surgical interven...

Autologous hematopoietic stem cell transplantation modulates epidermal-related inflammation/fibrosis mechanisms in systemic sclerosis patients

Abstract Background Autologous hematopoietic stem cell transplantation (auto-HSCT) has been shown to reduce cutaneous fibrosis and change dermal architecture in skin of systemic sclerosis (SSc) patients. However, its impact on the epidermis remains underexplored. Here, we examine...

HLA-DRB1 Polymorphisms Modulate the Dynamic Compatibility between the Presentation of EBNA1400–413 and MBP85–99

Abstract Multiple sclerosis (MS) shows a strong genetic association with HLA-DRB1 alleles and a consistent epidemiological association with Epstein–Barr virus (EBV) infection. However, it remains unclear how HLA-DRB1 polymorphisms modulate the presentation of autoantigens and vir...

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

Abstract The parasympathetic efferent innervation to the respiratory airways controls bronchoconstriction and mucus secretion. It is known that the parasympathetic respiratory motoneurones (PRMNs) projecting to the airways are located in the nucleus ambiguus (NA) and dorsal motor...

Cross-Sectional Validation of the NUTRISCORE Screening Tool in Outpatient Oncology Patients

BACKGROUND AND OBJECTIVE: Malnutrition in cancer patients is a complex and multifactorial condition. Validated nutritional screening instruments are essential to ensure diagnostic, accuracy and guide effective nutritional interventions. This study aimed to validate the NUTRISCORE...

Multi-omics analysis reveals Protein Kinase A-associated regulatory remodeling during adaptation of Trichoderma reesei to lignocellulosic substrate

The filamentous fungus Trichoderma reesei is a major industrial source of holocellulolytic enzymes, and its response to complex carbon sources is regulated by nutrient-sensing mechanisms, including the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway...

Neuroprotective effects of ketamine, lamotrigine, and ketoprofen combinations after pars plana vitrectomy and silicone oil injection

Abstract Purpose This experimental study aims to assess the protective impact of combined treatment with ketamine (KTM), lamotrigine (LMT), and ketoprofen (KTP), agents that have demonstrated neuroprotective properties in other experimental contexts, on rabbit retinas in an exper...

Albumin-based cationic nanoemulsion for Protoporphyrin IX delivery in normoxic and hypoxic conditions

Glioblastoma is one of the deadliest cancers in humans, but its treatment is limited by the difficulty drugs have in crossing the blood-brain barrier. Albumin-based nanomaterials have emerged as promising drug delivery systems for neurooncology applications, particularly for the...

Efficacy evaluation of a fermented milk containing inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharomyces cerevisiae to ameliorate the toxic effects of dietary aflatoxins and fumonisins in pigs: a pilot study

Abstract Inactivated microorganisms may reduce mycotoxins’ bioavailability, although in vivo evidence is limited especially in farm animals. This pilot study evaluated whether a fermented milk (FM) containing heat-inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharo...

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood–Brain Barrier Integrity in a Rat Model of Iron Overload

Abstract Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that excessive iron during early postnatal life induces oxidative reactions, lea...

Applicability of Retzius striae in forensic anthropology: a systematic review

Abstract Forensic Anthropology applies biological characteristics in legal contexts to estimate the biological profile of an unknown individual. In this regard, teeth stand out due to their resistance and ability to preserve valuable information over time. More specifically, micr...

Non-functional capillary modulates the honeymoon period in congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) results in lung hypoplasia and vascular remodeling with persistent pulmonary hypertension with significant mortality and morbidity. While only the analysis of the ‘’functional’’ gas-exchange capillary with diverging findings has been publishe...

The use of biologic adjuncts in tooth autotransplantation: a scoping review

PURPOSE: To summarize the available clinical evidence on biological adjuncts in tooth autotransplantation, including adjunct types, application protocols, procedural variables, reported outcomes, and evidence gaps. METHODS: This scoping review followed JBI guidance and PRISMA-ScR...