Clinical Emergency Hospital Bucharest

Diagnostic Yield and Incremental Value of 16S rRNA Gene PCR and Sequencing on Excised Heart-Valve Tissue in Infective Endocarditis: A Systematic Review and Meta-Analysis

Background/Objectives: Broad-range bacterial 16S rRNA gene PCR followed by sequencing may improve the etiological diagnosis of infective endocarditis (IE), particularly when conventional cultures are negative. This systematic review and meta-analysis evaluated the overall molecul...

The Role of Interleukin 17 in Association with Systemic Parameters in Severity Stratification and Mortality Prediction in Moderate and Severe Acute Pancreatitis

Introduction: Acute pancreatitis is an inflammatory lesion that can lead to multiple organ dysfunctions and has an increased mortality rate. The pathogenic mechanisms are complex. A central element is represented by systemic inflammation. This exploratory study aims to identify p...

Traumatic Intracranial Vascular Lesions in Adults Undergoing Vascular Imaging After Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Background and Objectives: Traumatic intracranial vascular lesions are rare but severe complications of traumatic brain injury (TBI) and include arterial and venous injuries such as arterial dissections, pseudoaneurysms, arterial occlusions, venous sinus thrombosis, arteriovenous...

Carbapenem-Resistant Klebsiella pneumoniae in Romania and South-Eastern Europe: A Multilingual Narrative Review of Pandemic-Era Trajectories, 2020–2025

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is the pathogen driving the deterioration of the European antimicrobial resistance landscape, and the burden falls disproportionately on Romania and South-Eastern Europe. The objective of this review was to synthesise evidence pub...

Diagnostic Performance of Diffusion-Weighted MRI and ADC Values in Differentiating Atypical Leiomyomas from Uterine Sarcomas.

BACKGROUND: Leiomyomas are the most common benign uterine tumors, whereas uterine sarcomas are rare malignant neoplasms associated with high morbidity and mortality. Differentiation using imaging remains challenging because of overlapping radiologic features. PURPOSE: To evaluate...

The Influence of Ageing, Sex and Cause of Death on the Myocardial Tissue Collagen Fibrillary Component Behaviour.

AIM: The morphology and the function of human body are influenced by two main factors: the passing of the years and the increasing diversity of diseases with their subsequent lesions. The morphological structures of the heart are not exempt from the synergistic influence of these...

Minimalist Footwear and Knee Joint Loading During Walking in Healthy Adults: A Systematic Review of Evidence for Osteoarthritis Prevention

Background/Objectives: Minimalist footwear has been proposed as a passive means of reducing knee loading, but its effects during walking in healthy adults, the population relevant to primary prevention of knee osteoarthritis (KOA), have not previously been synthesized. Methods: F...

Integrating Artificial Intelligence into Orthopedic Practice: Modeling Attitudes and Intentions to Use AI

Background/Objectives: Artificial intelligence is increasingly used in medicine, particularly in orthopedics, to support medical image interpretation, diagnosis, clinical decision-making, and treatment selection. Its integration into clinical practice depends largely on doctors’...

Malignancies in horseshoe kidneys: an updated review

Out of over 4000 available studies about horseshoe kidney (HSK), we selected 89 representative articles that emphasized the most common genetic lesions and tumors that can occur in these patients. Renal cell carcinomas, carcinomas of the urothelial tract, and Wilms tumor are the...

Admission Liver Injury Is an Independent Predictor of Early and Overall Mortality in Hospitalized Patients with Moderate-to-Critical COVID-19: A Retrospective Cohort Study

Background: Liver injury (LI) is frequently observed in patients with COVID-19, particularly in severe forms of disease. However, its prognostic significance remains incompletely defined. Aim: To evaluate the association between LI at admission and clinical outcomes in hospitaliz...

Sex-Related Differences in Clinical Characteristics and Outcomes Among Patients Clinically Managed for Suspected Bacterial Infection in the Emergency Department

Background and Objectives: Suspected bacterial infection is one of the leading presentations to the Emergency Department (ED) and is still associated with considerable morbidity and mortality. There is increasing evidence that biological sex may influence host immune responses, d...

Intraoperative Displacement of a Pterygoid Implant into the Pterygopalatine Fossa and Its Surgical Retrieval: A Case Report

Background/Objectives: Pterygoid implants are increasingly used to provide distal support in full-arch maxillary rehabilitation, improving biomechanical stability and reducing posterior cantilevers. Despite high reported survival rates, their placement is technically demanding be...

Cardiovascular–Kidney–Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review

Metabolic syndrome came to the attention of the scientific community several decades ago, and its definition has undergone multiple changes over time. It is currently defined by the coexistence of hypertension, central obesity, dyslipidemia, and impaired glucose metabolism, with...

Molecular profiling of thalassemia in Southeastern Romania

Abstract Background Thalassemias represent a major group of hereditary hemoglobin disorders with significant global health impact, yet molecular data from Eastern European populations, particularly from Romania, remain limited. Purpose This study was aimed at comprehensively char...

Epidemiological Assessment of Oral and Oropharyngeal Squamous Cell Carcinomas Before, During, and After the COVID-19 Pandemic, 2018–2024

Background/Objectives: Evidence regarding changes in oral and oropharyngeal squamous cell carcinoma (SCC) care across the COVID-19 pandemic remains limited, particularly in Eastern Europe. This study evaluated temporal changes in surgical admission volume, operative complexity, a...

Minimally Invasive Fassier–Duval Telescopic Rodding of the Lower Limb in Pediatric Osteogenesis Imperfecta: Current Evidence and Implications for Type I (Non-Deforming) Disease

Osteogenesis imperfecta (OI) is the most common heritable bone-fragility disorder, with type I (non-deforming OI) representing its mildest classical phenotype (historically referred to as Lobstein disease). Intramedullary (IM) rodding is essential for managing recurrent long-bone...

Reactive Blue 21 Dye Degradation and Surface Modification of Cu and Ag/Cu Thin Films Prepared by Pulsed Laser Deposition

In the present work, the potential applications of Cu thin films and Ag/Cu bilayer thin films obtained by the pulsed laser deposition (PLD) technique are investigated in terms of the physicochemical effects resulting from their interaction with an aqueous solution containing Reac...

Revisiting gallbladder stones structure through integrated multiscale physicochemical characterization

Gallstones are complex biominerals formed through physicochemical, metabolic, and microbial processes. In this study, gallstones were comprehensively characterized, revealing a complex elemental profile comprising C, N, O, Mg, Al, Si, P, S, Ca, Cu, Mn, Fe, Co, Zn, and Cd. The cha...

Predictive Factors for Acute and Late Genitourinary and Gastrointestinal Toxicity Following Modern Radiotherapy for Prostate Cancer: A Narrative Review of Clinical, Dosimetric, Immunological, and Genetic Determinants

Background: Despite advances in prostate cancer (PC) radiotherapy, including intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiotherapy (SBRT), genitourinary (GU) and gastrointestinal (GI) toxicities remain important compl...

Bioactive Multilayer Poly(ε-caprolactone)–Chitosan Coatings for Spinal Screws

Spinal surgery involves highly complex procedures where the risk of severe complications, including postoperative infections, may compromise both surgical success and patient survival. In this study, functional coatings for spinal screws were developed to promote bone integration...