Clinical Emergency Hospital Bucharest

Physicians Retain Moral Responsibility but Endorse Institutional Co-Responsibility in AI-Assisted Decisions: An Exploratory Vignette Study

Background: Artificial intelligence (AI) systems, including large language models, are increasingly used in clinical practice, whether consulted informally by clinicians or introduced by employers into decision workflows. It remains unclear how physicians attribute moral responsi...

Comparison of the Alvarado Score with Alternative Diagnostic Tools in Pediatric Acute Appendicitis: A Literature Review

Background: Acute appendicitis is a leading pediatric surgical emergency. Timely diagnosis remains challenging, particularly in young children with atypical presentations. Clinical evaluation alone yields variable diagnostic performance, prompting the use of risk stratification t...

Association Between Graves’ Disease and the Risk of Thyroid Carcinoma: The Role of Clinical, Metabolic, Hormonal, Immunological, and Ultrasound Biomarkers

Background: The relationship between Graves’ disease (GD) and thyroid carcinoma (TC) remains controversial, particularly regarding the predictive value of metabolic, hormonal, immunological, and ultrasound biomarkers. We performed a systematic review and meta-analysis to evaluate...

From Medical Records to AI-Ready Datasets: A Practical Guide for Clinical Researchers

Background: Medical artificial intelligence (AI), machine learning (ML), and deep learning (DL) studies frequently begin with datasets collected for routine care rather than for computational modeling. Such datasets may contain inconsistent variables, heterogeneous measurement ti...

Comparative Analysis by Machine Learning of Geriatric Frailty and Alzheimer’s Disease Classification Using Independent Datasets

Frailty syndrome and Alzheimer’s disease are prevalent conditions in the elderly that are associated with aging, decreased quality of life, and a significant healthcare burden. Evidence for a relationship between physical frailty and neurodegenerative decline is accumulating. Thi...

Rectal Surveillance for Carbapenem-Resistant Klebsiella pneumoniae: Prevalence and Clinical Relevance in a Multidisciplinary Tertiary-Care Hospital

Background/Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a high-priority healthcare-associated pathogen. This study aimed to estimate rectal CRKP carriage and characterize same-patient clinical-site CRKP detection. Methods: We conducted a single-center retrospe...

Association of Serum 25-Hydroxyvitamin D, Inflammatory, and Metabolic Biomarkers with Non-Proliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Background: Non-proliferative diabetic retinopathy (NPDR) is a common microvascular complication of type 2 diabetes mellitus (T2DM) associated with chronic inflammation, metabolic dysregulation, and multiple interacting systemic factors. This study evaluated the associations of i...

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...

Integrated Analysis of Zinc, Copper, and Magnesium Homeostasis in Pediatric Idiopathic Nephrotic Syndrome: A Prospective Cohort Study with Serial Clinical Evaluation

Background: Idiopathic nephrotic syndrome (NS) in children is characterized by urinary protein loss and potential disruptions in trace element homeostasis. The dynamic changes in zinc, copper, and magnesium levels in relation to disease activity remain incompletely defined. Objec...

Changing Etiological Patterns of Pediatric Meningitis: A Three-Year Experience from a Tertiary Pediatric Emergency Hospital in Romania

Background and Objectives: Pediatric meningitis remains a major diagnostic and therapeutic emergency because clinical presentation may be nonspecific and early etiological distinction directly influences treatment, infection control, and epidemiological surveillance. Although bac...

Multivariable Associations of Anthropometric and Psychosocial Markers with an Elevated Abdominal Volume Index Among University Students: A Sex- and Academic Program-Stratified Analysis

Background: The Adiposity Volume Index (AVI) is a modern geometric tool for tracking central body fat. However, how it interacts with prenatal markers (2D:4D ratio), advanced anthropometric indexes, and psychological factors across different academic disciplines remains largely u...

Cardiovascular Complications Associated with Uro-Oncology Treatments—A Primer for the Clinician

Cardiovascular complications increasingly challenge survivors of urological cancers, given the cardiotoxicity of therapies such as androgen deprivation, vascular endothelial growth factor receptor inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, and chemother...

Urinary Leakage During Sexual Activity: A Narrative Review of an Underdiagnosed Female Pelvic Floor Disorder

Coital urinary incontinence is a frequently underdiagnosed manifestation of female pelvic floor dysfunction, characterized by involuntary urine leakage during sexual activity, particularly during vaginal penetration or orgasm. Although interest in this condition has increased in...

Ureaplasma Species in Perinatal Disease: From the Age of Innocence to the Missing Villain

Ureaplasma urealyticum and Ureaplasma parvum occupy an odd place in perinatal medicine: dismissed for decades as harmless residents of the female genital tract, they are now recognized as pathogens with real consequences for preterm newborns. This review traces that paradigm shif...

Maternal Cardiovascular Phenotype in Fetal Growth Restriction with or Without Pre-Eclampsia: Insights from Echocardiography and Clinical Implications

Fetal growth restriction (FGR) has traditionally been attributed to placental insufficiency. However, accumulating evidence suggests that maternal cardiovascular maladaptation contributes to disease expression, clinical heterogeneity, and long-term maternal cardiovascular risk. T...