Chongqing Three Gorges University

Zoonotic and prey-derived protozoa in Tibetan fox ( Vulpes ferrilata ) and other wild canids: Implications for public health in the eastern Tibetan Plateau

Enteric protozoan infections-cryptosporidiosis, giardiasis, microsporidiosis, and coccidiosis-constitute a significant global burden on human and animal health. Yet comprehensive parasitological surveys of wildlife in the eastern Tibetan Plateau, where anthropogenic, livestock, a...

Genomic prospecting and biochemical characterization of a novel thermostable 3-quinuclidinone reductase from hot spring metagenomes for efficient biocatalysis

ABSTRACT This study presents the discovery and characterization of a novel thermophilic 3-quinuclidinone reductase (ScQR) identified through metagenomic mining of hot spring environments. ScQR, a member of the short-chain dehydrogenase/reductase (SDR) superfamily, was heterologou...

Cell Type–Resolved Causal Inference and Spatial Transcriptomic Integration Reveal Immune‐Specific Genetic Drivers of Autoimmune and Malignant Thyroid Disease

ABSTRACT Background : Thyroid diseases, including autoimmune thyroid disease (AITD) and thyroid cancer, are characterized by immune dysregulation, yet the cell type–specific genetic mechanisms underlying these conditions remain poorly understood. Most genome‐wide association stud...

Factors influencing inhaled medication adherence among hospitalized patients with chronic obstructive pulmonary disease from rural and township areas of China with prior primary care experience: a mixed-methods study

Patients with chronic obstructive pulmonary disease require long-term medication to control their symptoms. This study explored factors influencing adherence to inhaled medications in hospitalized patients with chronic obstructive pulmonary disease who resided in rural and townsh...

A novel lightweight tetrachiral metamaterial enabled by additive manufacturing for tunable mechanical response

Tetrachiral cylindrical metamaterials exhibit unique deformation characteristics arising from their rotational unit-cell topology and continuous ligament network. While their global mechanical behavior is strongly governed by geometric parameters, the specific influence of ligame...

Environmental drivers and machine-learning analysis of grapevine sap flow on hilly slopes in Southwest China

Global climate change has increased the frequency and intensity of high-temperature droughts, threatening fruit production in the fragile hilly regions of Southwest China. Grapevine ( Vitis labrusca×vinifera ‘Shine Muscat’ ) is widely grown there, but its sap flow dynamics under...

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

The Operational Logic of Ecocentrism and Its Critical Reflection: A Žižekian Analysis of Ideological Fantasy

This article examines Slavoj Žižek’s critique of ecocentrism through the lens of Lacanian ideology theory, asking how the ecological crisis is symbolically organized in contemporary discourse. Rather than treating ecocentrism as a coherent ecological doctrine, it approaches it as...

A cfDNA fragmentomics-based liquid biopsy assay for early detection of oral cancer

Abstract Background Early detection of oral cancer improves outcomes, but remains limited by the invasiveness and low sensitivity of current screening methods. Methods This study included 342 participants (200 in the training and 142 in the validation cohorts). Plasma cfDNA under...

Levistilide A promotes ferroptosis through the RNF40-HSP90α axis and inhibit colorectal cancer lung metastasis

Abstract The molecular mechanisms underlying lung metastasis of colorectal cancer (CRC) remain largely elusive, and effective therapeutic agents are still lacking. In this study, we identify levistilide A (LeA) as a potential anti-metastatic agent against CRC lung metastasis. We...

Predicting pupillary response and identifying lighting thresholds in road tunnels using bacterial foraging optimization-based stacking ensemble model

The lighting conditions of road tunnels vary sharply across threshold, interior, and exit zones, imposing substantial visual adaptation demands on drivers and directly affecting pupillary response. To improve the prediction accuracy of pupil diameter and identify the nonlinear th...

Visibility-driven compensation model for driver pupillary response in road tunnels: a GWO-XGBoost and SHAP-based interpretable framework

Pupil diameter, as a sensitive indicator integrating photometric stimulation and mental workload, provides an effective bridge between tunnel visual conditions and drivers’ psychophysiological states. This study conducted real-vehicle field experiments in four tunnels with differ...