Chongqing Three Gorges University

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

The Operational Logic of Ecocentrism and Its Critical Reflection: A Žižekian Analysis of Ideological Fantasy

This article examines Slavoj Žižek’s critique of ecocentrism through the lens of Lacanian ideology theory, asking how the ecological crisis is symbolically organized in contemporary discourse. Rather than treating ecocentrism as a coherent ecological doctrine, it approaches it as...

Levistilide A promotes ferroptosis through the RNF40-HSP90α axis and inhibit colorectal cancer lung metastasis

Abstract The molecular mechanisms underlying lung metastasis of colorectal cancer (CRC) remain largely elusive, and effective therapeutic agents are still lacking. In this study, we identify levistilide A (LeA) as a potential anti-metastatic agent against CRC lung metastasis. We...

A cfDNA fragmentomics-based liquid biopsy assay for early detection of oral cancer

Abstract Background Early detection of oral cancer improves outcomes, but remains limited by the invasiveness and low sensitivity of current screening methods. Methods This study included 342 participants (200 in the training and 142 in the validation cohorts). Plasma cfDNA under...

Predicting pupillary response and identifying lighting thresholds in road tunnels using bacterial foraging optimization-based stacking ensemble model

The lighting conditions of road tunnels vary sharply across threshold, interior, and exit zones, imposing substantial visual adaptation demands on drivers and directly affecting pupillary response. To improve the prediction accuracy of pupil diameter and identify the nonlinear th...

Visibility-driven compensation model for driver pupillary response in road tunnels: a GWO-XGBoost and SHAP-based interpretable framework

Pupil diameter, as a sensitive indicator integrating photometric stimulation and mental workload, provides an effective bridge between tunnel visual conditions and drivers’ psychophysiological states. This study conducted real-vehicle field experiments in four tunnels with differ...