Chongqing Three Gorges Central Hospital

Synthesis of Pyrroloquinazolinones via Base-Promoted Domino Reaction of 7-Vinylindoles with In Situ Formed Isocyanates from Dioxazolones

Abstract Herein, we report a novel base-promoted domino reaction between 7-vinylindoles and dioxazolones, enabling the efficient one-pot synthesis of pyrroloquinazolinone scaffolds in moderate to excellent yields (up to 95%). This transition-metal-free protocol employs readily av...

MicroRNA-2110 acts as a tumor suppressor in gastric cancer via direct targeting of IGF1R

Abstract Background MicroRNA-2110 has been implicated in cancer, but its expression and function in gastric cancer (GC) remain understudied. This study aims to explore the role of miR-2110 in GC and its regulation of IGF1R. Methods RT-qPCR was used to measure miR-2110, IGF1R expr...

Factors influencing inhaled medication adherence among hospitalized patients with chronic obstructive pulmonary disease from rural and township areas of China with prior primary care experience: a mixed-methods study

Patients with chronic obstructive pulmonary disease require long-term medication to control their symptoms. This study explored factors influencing adherence to inhaled medications in hospitalized patients with chronic obstructive pulmonary disease who resided in rural and townsh...

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

A cfDNA fragmentomics-based liquid biopsy assay for early detection of oral cancer

Abstract Background Early detection of oral cancer improves outcomes, but remains limited by the invasiveness and low sensitivity of current screening methods. Methods This study included 342 participants (200 in the training and 142 in the validation cohorts). Plasma cfDNA under...