Chongqing Medical University

Efficiency vs. safety in AI-enabled medical education: an ethical analysis of AI as a bridge or a wedge

Abstract: Artificial intelligence is rapidly changing medical education, promising faster workflows and richer learning resources while quietly reshaping how future clinicians think and act. This paper examines the central tension between efficiency and safety in AI-enabled medic...

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with limited therapeutic options. Berberine exhibits renoprotective potential, yet its precise molecular targets and mechanisms of action in DN remain unclear. Berberine targets were retrieved from TCMSP...

Construction and Exploration of the Three-Dimensional Dual Closed-Loop Safety Management System for Special Equipment

Based on the analysis of the inherent drawbacks of routine safety inspections and the objective advantages of unannounced inspections for logistics support in large medical institutions, it is concluded that proactive safety boasts broad application space and far-reaching prospec...

National Epidemiological Trends in Hepatitis A–E Serologic and Virologic Markers in the United States, 2011–2023: A Population-Based Study

Viral hepatitis caused by A to E imposes a substantial global burden of liver disease. Despite US control strategies, long-term national data covering serologic markers of all five hepatitis viruses remain limited. In this study, we analyzed epidemiologic trends from 2011 to 2023...

Quadruple superior shoulder suspensory complex injury with bony Bankart lesion: a case report

We present a 37-year-old male with a quadruple injury of the superior shoulder suspensory complex (SSSC), comprising acromial fracture, coracoid process fracture, acromioclavicular joint dislocation, and bony Bankart lesion, following a 3-meter fall. Multimodal imaging (X-ray, 3D...

The Association of Essential Micronutrients in Serum with Immune-Mediated Inflammatory Diseases: A Cross-Sectional Study from NHANES

Background: Immune-mediated inflammatory diseases (IMIDs) occur when the immune system attacks the body’s own tissues, affecting approximately 8% of the global population. Objective: This study investigated the serum levels of a few redox-relevant essential micronutrients, aiming...

Associations between hypertensive diseases of pregnancy and birthweight outcomes in twin pregnancies: A large‐scale retrospective cohort study

OBJECTIVE: This study aimed to assess the association between hypertensive disorders of pregnancy (HDPs) and birthweight outcomes in twin pregnancies, an area that remains underexplored compared to the well-documented short- and long-term effects of HDPs in singleton pregnancies....

Operating room spatial layout, capacity utilization, and resource efficiency: evidence from a tertiary hospital in China

Purpose Operating rooms (ORs) are among the most resource-intensive hospital units. This study examines how OR spatial layout influences surgical preparation time, staff movement, equipment utilization, patient flow, and OR utilization in a large tertiary hospital in China. Desig...

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

ABSTRACT Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co‐capture sensitivity, proprietary platforms, and high costs. Here we p...

Cisplatin combined with high-intensity focused ultrasound inhibits endometrial cancer progression by inducing pyroptosis

Background Cisplatin-based chemotherapy is limited by toxicity and resistance.High-intensity focused ultrasound (HIFU) is a noninvasive ablation technique with potential to enhance chemotherapy efficacy.Objective To investigate the anti-tumor effects and mechanisms of cisplatin c...

Association between total calcium intake and depressive symptoms in cancer survivors based on the National Health and Nutrition Examination Survey (NHANES) 2007–2018: a cross-sectional study

Abstract Though previous studies have explored the relationship between Ca intake and depressive symptoms, epidemiological evidence on cancer survivors remains limited. This study aimed to investigate the association between estimated total Ca intake and depressive symptoms among...

Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation

BACKGROUND: Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma bio...

Resiquimod Improves the Tumor Accumulation and Antitumor Activity of SN38 Prodrug-Loaded Liposomes

Abstract The effectiveness of liposome-based antitumor drugs is significantly limited by the poor tumor accumulation of liposomes. Herein, we report that resiquimod (R848) can selectively increase tumor accumulation of 7-Ethyl-10-hydroxycamptothecin (SN38)-loaded liposomes (SN38-...

Regional structural–functional connectivity decoupling is associated with glymphatic-related dysfunction and cognitive performance in cerebral small vessel disease: a multimodal MRI study

Regional structural–functional connectivity (SC-FC) coupling and glymphatic-related MRI markers may provide complementary insights into cognitive impairment in cerebral small vessel disease (CSVD). However, their interrelationship and cognitive relevance remain unclear. This cros...

Development and validation of a predictive model for osteoporosis in middle-aged and older patients with type 2 diabetes mellitus: a multicenter retrospective study

The increasing prevalence of type 2 diabetes mellitus (T2DM) and osteoporosis (OP) among aging populations necessitates early OP risk identification. This study developed and validated a nomogram for predicting OP risk in middle-aged and older T2DM patients, and explored dose-res...

Comment on ‘Effectiveness, safety and tolerability of ozenoxacin 2% lotion vs clindamycin 1% lotion in mild to moderate truncal acne’: considerations regarding sample size and treatment-related withdrawal

This letter discusses two methodological considerations in a randomized trial comparing ozenoxacin 2% lotion with clindamycin 1% lotion for mild-to-moderate truncal acne. We highlight uncertainty regarding the sample-size calculation and the handling of treatment-related withdraw...

Inflammation-associated hsa_circ_0054391 regulates epithelial-mesenchymal transition and vasculogenic mimicry in colorectal cancer via the miR-1252-3p/VEGFA/ZEB1 axis

Abstract To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls ( n =...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

Effect of refractive correction of myopia on health-related quality of life among children aged 3–12 years: a prospective observational cohort study

To analyze refractive changes and health-related quality of life (QOL) in children with myopia aged 3–12 years and to explore the effects of refractive correction on the QOL of children in different age groups and their parents. A 1-year prospective cohort study was conducted wit...

The pregnancy vaginal microbiota exhibits alterations in association with gravidity, parity, and miscarriage history: a cohort study

Vaginal microbiota plays a critical role in reproductive health, yet the impact of woman’s obstetric history including gravidity, parity and miscarriage history, remains inadequately characterized. We conducted a cohort study to identify microbial biomarkers linked to these facto...