Chongqing Medical University

The endothelial PECAM1–CXCR4 axis amplifies neutrophil degranulation to exacerbate sleep-deprived periodontitis: a systems-level framework for comorbidity therapy

Sleep deprivation (SD) is a known risk factor for periodontitis (PD), but the molecular bridge connecting this systemic stressor to local inflammation remains elusive. Here, through a systems-level investigation integrating human epidemiology, multi-omics, and disease modeling, w...

A 9 + 1 multi-agent collaborative teaching model for clinical reasoning: integrating large language models into medical education

Clinical reasoning—the cognitive and metacognitive processes through which clinicians collect and interpret patient information, generate and test diagnostic hypotheses, and make clinical decisions—is a core competency in medical education. Since 1956, clinical educators have inn...

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Temporal dynamics of PrEP adherence, self-efficacy, and risk perception among men who have sex with men in western China: a cross-lagged panel network analysis

<title>Abstract</title> Background Pre-exposure prophylaxis (PrEP) effectively reduces HIV infection risk among men who have sex with men (MSM), but its benefit depends on adherence. The longitudinal item-level relationships among PrEP adherence, self-efficacy, and risk perceptio...

Deep learning-powered virtual eosin-based elastic fiber framework imaging improves objective grading and prognostic stratification of lung adenocarcinoma

Histological grading of lung adenocarcinoma is limited by interobserver variability, particularly when distinguishing noninvasive lepidic growth from invasive patterns. This distinction depends on evaluation of the alveolar elastic fiber framework, which is often insufficiently v...

A ROS-Responsive Photothermal Hydrogel for Tumor Microenvironment Reprogramming and STING-Mediated Immune Engagement

Photothermal therapy can induce local tumor cell death and trigger antitumor immune responses. However, its efficacy is often limited by insufficient lymph node immune priming and by sustained ROS generated from thermal stress, which suppress immune cell function. An oxidative-st...

Selective Intrinsically Photosensitive Retinal Ganglion Cells Ablation Regulates Myopia Development Through the Choroid/MAPK Pathway

Purpose This study investigates the role of selective ablation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in regulating axial length (AL) and scleral remodeling during myopia progression.Methods Three-week-old pigmented guinea pigs were randomly assigned to f...

Knowledge, attitude, and practice toward osteoporosis among middle-aged and elderly women in northeastern coastal areas of China

Osteoporosis is highly prevalent among postmenopausal and elderly women due to hormonal changes and aging-related bone loss. This study evaluated the knowledge, attitudes, and practices (KAP) regarding osteoporosis among middle-aged and elderly women in northeastern coastal China...

Levistilide A promotes ferroptosis through the RNF40-HSP90α axis and inhibit colorectal cancer lung metastasis

Abstract The molecular mechanisms underlying lung metastasis of colorectal cancer (CRC) remain largely elusive, and effective therapeutic agents are still lacking. In this study, we identify levistilide A (LeA) as a potential anti-metastatic agent against CRC lung metastasis. We...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Generalizable 3′-Hydroxyl-Regenerating PrimerPlatform for Photoactivatable DNA Polymerase Regulation in NucleicAcid Amplification

Abstract Precise regulation of DNA polymerase activity remains a central challenge in nucleic acid amplification, particularly in systems susceptible to nonspecific amplification. Here, we report a generalizable 3′-hydroxyl-regenerating primer platform for photoactivatable DNA po...

TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...

A portable nanobiosensor with machine learning: enabling multi-cytokines point-of-care testing and early identification of sepsis immunoparalysis

Abstract Sepsis immunoparalysis (SIs) is a major factor contributing to organ dysfunction. However, emergency departments (EDs) and intensive care units (ICUs) currently lack a rapid workflow for early identification of SIs. Herein, an innovative strategy for early SIs identifica...

MRI-based radiomic models of subchondral bone for predicting the occurrence of knee osteoarthritis

To extract the MRI-based radiomic features of subchondral bone, and establish multi-regional radiomic models and delta-radiomic models for predicting the 2-year risk of knee osteoarthritis (KOA). The data used in this study were obtained from the osteoarthritis initiative (OAI)....

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

A Rapid Method for the Identification and Screening of Bitter Compounds Using Moslae Herba as a Case Study

ABSTRACT Moslae Herba, a commonly used traditional Chinese medicine with both diaphoretic and diuretic properties, exhibits intense bitterness in its clinical decoction, which severely compromises patient compliance. As a highly representative and typical case among bitter‐tastin...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

BifunctionalIonophores for Cuproptosis Activation:Dual Targeting of Copper and Fe–S Protein Homeostasis

Abstract Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron–sulfur (Fe–S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe–S cluster homeostasis,...

Enhancing Oligodendrogenesis Rescues Chronic Stress‐Induced Behavioral Disorders Involving Neuronal and Synaptic Reorganization

ABSTRACT Chronic stress induces psychiatric disorders, including depression and anxiety, yet effective therapies remain limited. Myelin in adult brains undergoes dynamic remodeling through oligodendrocyte precursor cells (OPCs) differentiation into oligodendrocytes (OLs) and the...

Sirtuin 4 knockout exacerbates cardiac injury in septic cardiomyopathy via activating the MAPK-JNK pathway

Septic cardiomyopathy (SCM) significantly contributes to mortality among septic patients, and its mechanism is closely related to abnormal inflammatory responses. Previous studies revealed the essential role of the Sirtuin4 gene in cardiomyocyte and myocardial function; however,...