Chongqing Medical University

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

ABSTRACT Hepatic ischemia‒reperfusion injury (HIRI) critically compromises liver surgery and transplantation outcomes. Its pathogenesis centers on mitochondrial dysfunction‐driven oxidative stress and sterile inflammation. However, current therapies lack lesion‐specific targeting...

Association of sulfur microbial diet with lung cancer incidence and lung cancer-related mortality in 95,612 American adults: a prospective cohort study from the PLCO trial

The sulfur microbial diet (SMD) score is a microbiome-related dietary proxy derived from food groups associated with sulfur-metabolizing bacteria. Whether it is associated with lung cancer remains unclear. We analyzed 95,612 participants from the Prostate, Lung, Colorectal, and O...

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O ‐GlcNAcylation‐Induced m6A Demethylation of HRAS

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is driven by nutrient stress through incompletely defined epigenetic mechanisms. This study demonstrates that lipid stress activates the hexosamine biosynthesis pathway (HBP), elevating O ‐linked β‐N‐acetylglucosami...

Behavioral and electrophysiological characteristics of auditory atypicalities in children with autism spectrum disorder

Sensory atypicalities, particularly auditory, are highly prevalent in children with autism spectrum disorder (ASD). Objective electrophysiological indices for characterizing these differences are lacking. Mismatch Negativity (MMN) reflects automatic auditory processing at the pre...

Chiral Solid-State Nanopores Amplify Secondary Interactions for Ionic-Current Discrimination of Neurotransmitter Enantiomers

Abstract Single-molecule ionic-current sensing provides a powerful electroanalytical route for resolving small-molecule enantiomers, yet reliable discrimination remains difficult when stereochemical differences generate only weak and transient interfacial interactions. Here, we e...

Identification and validation of biomarkers related to integrated stress response in ischemic stroke based on transcriptomics

Abstract Ischemic stroke (IS) is a prevalent cerebrovascular disorder. Integrated stress response (ISR) plays an important role in multiple cerebrovascular diseases, its specific involvement and associated biomarkers in IS remain incompletely understood. This study aimed to ident...

Isoliquiritigenin Triggers HMOX1-Driven Ferroptosis to Suppress Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death, and new treatment strategies are needed. Ferroptosis is an iron-dependent cell death driven by lipid peroxidation, and targeting ferroptosis has become a new strategy for anti-NSCLC. Isoliquirit...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

COPD/OSA phenotypes and inpatient outcome patterns among primary total hip arthroplasty hospitalizations: a national inpatient sample study, 2016–2022

Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are common among patients undergoing total hip arthroplasty (THA), but whether COPD-only, OSA-only, and coexisting COPD + OSA define distinct inpatient risk phenotypes remains unclear. This retrospecti...

Multimodal analysis identifies a fibroblast subtype enriched in EGFR-mutant NSCLC and its spatial niches

Abstract Background The tumor microenvironment (TME) in non-small cell lung cancer (NSCLC) exhibits heterogeneity across distinct oncogenic driver mutations, but whether specific stromal states are shaped by these mutations and how they influence tumor progression and therapy res...

Cross-species single-nucleus transcriptomics identifies microglial Arhgap22 as a conserved modulator of synaptic phagocytosis and depression-related behaviors

Abstract Microglia-regulated neuroinflammation is associated with major depressive disorder (MDD), yet the molecular drivers of pathological microglia-neuron interactions remain poorly defined. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) of the prefrontal cortex...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Shared genetic architecture underlying cataract and cardiovascular disease: insights from multi-omics analyses

Abstract Cataract and cardiovascular disease (CVD) are prevalent age-related disorders with overlapping risk factors. While epidemiological associations are established, the shared genetic mechanisms underlying their comorbidity remain largely unexplored. We performed a comprehen...

A dual-functional, responsive nanomodulator alleviates pyroptosis-associated lung injury in ARDS by selectively suppressing the cGAS–STING signaling axis

Injury and inflammation mediated by pulmonary endothelial cell pyroptosis are crucial factors in the progression of acute respiratory distress syndrome (ARDS). Although blocking the cyclic GMP‒AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway is a promi...

Successful use of nafamostat mesilate anticoagulation in V-V ECMO for refractory diffuse alveolar hemorrhage secondary to ANCA-associated vasculitis: case report and review of the literature

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Veno-venous extracorporeal membrane oxygenation (V-V ECMO) serves as a salvage respiratory support for patients with severe hypoxemia u...

Pulmonary nodules in breast cancer patients: prevalence, diagnostic intervention rate, and pathologic spectrum

Pulmonary nodules are frequently detected during staging or follow-up in breast cancer, yet their prevalence, the use of invasive diagnostic intervention, and the pathologic spectrum remain uncertain. We searched PubMed, Embase, Web of Science, Cochrane Library, and Chinese datab...

Single-Atom Nanozyme Integrated Double-Clasp Transition Probe-Driven CRISPR/Cas12a Cascade for Preamplification-Free Detection of Non-Nucleic Acid Targets

Abstract CRISPR/Cas12a diagnostics have greatly advanced nucleic acid testing, yet their extension to non-nucleic acid targets remains constrained by the intricate preamplification process and by inefficient signal transduction. Herein, we present a non-nucleic acid detection pla...

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with limited therapeutic options. Berberine exhibits renoprotective potential, yet its precise molecular targets and mechanisms of action in DN remain unclear. Berberine targets were retrieved from TCMSP...