Chinese University of Hong Kong, Shenzhen

ARID1B promotes DNA end resection via MDC1 and co-transactivation of DNA repair genes with c-MYC in small cell lung cancer

Abstract AT-rich interactive domain-containing protein 1B (ARID1B) has been implicated in DNA damage repair; however, its precise molecular mechanisms and contributions to small cell lung cancer (SCLC) pathogenesis remain incompletely defined. In this study, analysis of clinical...

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond

ABSTRACT The traditional drug discovery and development (DDD) pipeline has long been characterized by inefficiency and high costs. The rapid evolution of artificial intelligence (AI), especially AI‐based toolkits for protein structure and interaction prediction, exemplified by Al...

Efficient and Polarized Emission From Cs 3 Cu 2 Br 5 Nanorods via Dithiol Ligand Exchange

ABSTRACT Ternary copper halides, such as Cs 3 Cu 2 X 5 (X = Cl, Br, or I), are a new class of lead‐free nanocrystals with exceptional optical properties, making them promising for photo‐down‐conversion display applications. However, recent studies on blue‐emitting ternary copper...

Catalyst-free Polyannulations of Potassium Sulfide and Unactivated Alkynes toward Multifunctional Thiophene-Containing Polymers

Abstract Facile and efficient transformation of inexpensive inorganic sulfides into high-value polymer materials is of great academic and industrial significance. Herein, we report a catalyst-free polyannulation strategy between potassium sulfide and internal diynes, which can ef...

Designing a hybrid surgical ICU to avoid intrahospital transport in selected critically Ill patients: the CUHK-SZ institutional concept

Intrahospital transport for surgery exposes critically ill patients to equipment failure, displacement of tubes and lines, interrupted monitoring, and physiologic instability. Although transport protocols can reduce these hazards, they do not address the underlying physical decou...

The BdryMatérn GP: A New Gaussian Process Model for Incorporating Boundary Information

Abstract. Gaussian processes (GPs) are broadly used as surrogate models for expensive computer simulators of complex phenomena. However, a key bottleneck is that its training data are generated from this expensive simulator and thus can be highly limited. A promising solution is...

Using Aromatic‐Bridge‐Tuned Dimer Acceptors to Harmonize Photoluminescence Quantum Yield and Crystallinity for Organic Solar Cells Exceeding 21% Efficiency

ABSTRACT Suppressing non‐radiative energy loss (Δ E 3 ) by enhancing the photoluminescence quantum yield (PLQY) of active‐layer materials, particularly the acceptor component, is important for achieving high‐performance organic solar cells (OSCs). A key challenge is how to design...

Harnessing Differential Restriction of Molecular Motion within a Single Fluorophore for Versatile Bioimaging

Abstract Numerous studies have highlighted how differently restricted molecular motions within molecular packing can profoundly alter the photophysical properties of fluorophores. However, most investigations remain confined to solid-state luminescence polymorphism, while extendi...

Value-at-Risk- and Expectile-Based Systemic Risk Measures and Second-Order Asymptotics: With Applications to Diversification

Abstract. Systemic risk measures play a crucial role in analyzing individual losses conditional on extreme system-wide disasters. In this paper, we provide a unified asymptotic treatment for systemic risk measures. First, we classify them into two families of Value-at-Risk- (VaR-...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Structure-based identification and biological evaluation of a novel MAPKAPK2 inhibitor for pancreatic cancer

Pancreatic cancer remains a lethal malignancy with few effective treatment options. MAPKAPK2, a downstream effector of p38 signaling, represents a potential target for disrupting tumor survival pathways. Structure-guided computational screening has become an important strategy fo...

Machine learning clustering of multidimensional clinical features identifies four prognostically distinct sepsis subtypes

Sepsis is highly heterogeneous, and traditional “one-size-fits-all” treatment approaches are insufficient for optimal risk stratification. Using the MIMIC-III database, we employed unsupervised machine learning (k-means clustering) based on eight key clinical features (age, SOFA...

Spatial organization and coordinated development of offshore wind industrial chains under governance decentralization: evidence from China's coastal provinces

Offshore wind industrial chains, encompassing upstream component manufacturing, midstream project development and operation, and downstream grid integration, underpin large-scale utilization, yet their spatial organization, structural linkages, and coordinated development remain...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

Metamorphic Coverage

Metamorphic testing is a widely used methodology that examines an expected relation between pairs of executions to automatically find bugs, such as correctness bugs. We found that code coverage cannot accurately measure the extent to which code is validated and mutation testing i...

An AIEgen‐Based Covalent Organic Polymer With NIR‐II Emission for 980 nm Excitable Tumor Phototheranostics

ABSTRACT Covalent organic porous polymers (COPs) represent an attractive platform for phototheranostics due to their structural tunability and extended conjugation. Nevertheless, achieving COPs that simultaneously exhibit efficient second near‐infrared (NIR‐II) fluorescence and l...

Illness Experiences and Supportive Care Needs of Patients With Early‐Onset Colorectal Cancer: A Qualitative Systematic Review

AIMS: To synthesise the holistic illness experiences and supportive care needs of patients with early-onset colorectal cancer across the entire disease trajectory. BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed in indivi...

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

ABSTRACT Traditional fluorogenic and cell‐permeable molecular probes for live‐cell nanoscopy mainly rely on structural or hydrophilicity changes to generate intracellular fluorescence signals. Here, we introduce molecular machines into fluorogenic probe design. As a proof of conc...

Cholecystoduodenal Fistula, Gallstone Ileus, and Choledocholithiasis: A Case Report and Literature Review

ABSTRACT Prompt diagnosis using CT is critical in gallstone ileus, as symptoms are often nonspecific. A combined surgical approach—comprising enterolithotomy, cholecystectomy, and fistula repair—effectively addresses both the obstruction and its underlying source, achieving favor...