Chinese University of Hong Kong, Shenzhen

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

Optimal Consumption Under Loss-Averse Multiplicative Habit Formation Preferences

Abstract. This paper studies a loss-averse version of the multiplicative habit formation preference and the corresponding optimal investment and consumption strategies over an infinite horizon. The agent’s consumption preference is depicted by a general S-shaped utility function...

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

Assortment Optimization for the Multinomial Logit Model with Repeated Customer Interactions

This paper presents the multinomial logit model with repeated customer interactions. In each period, the same customer selects a product from the recommended assortment or opts out. From the seller’s perspective, the choice probability in the current period is updated based on th...

MARMOT: masked autoencoder for modeling transient imaging

Abstract Pretrained models have recently emerged as effective priors for a wide range of vision and computational imaging problems. Transient measurements have emerged as a new imaging modality, in which a time-resolved sensor records photon counts over time bins. In confocal non...

A new platform for achieving long-term air-stable long persistent luminescence in amorphous organic system

Abstract Organic long persistent luminescence (OLPL) materials are at the forefront of research, undergoing rapid evolution due to their extensive potential applications. The realization of hour-level OLPL, particularly an air-stable one, remains a significant challenge. Here, we...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

Collective resonance light scattering from thermally relaxing systems in cavities

We study steady-state resonance light scattering from ensembles of noninteracting molecules, both in free space and inside optical cavities, while accounting for local thermal relaxation. The scattering spectra are obtained from steady-state solutions of either the Schrödinger eq...

Structural Designof AlGaN Deep-Ultraviolet Laserat Wavelength 266.3 nm with Graded Electron Blocking Layer and CompositeQuantum Wells/Barriers

Abstract Deep-ultraviolet laser diodes (DUV LDs) are developing as vigorous light sources for sterilization, lithography, purification, and biochemical sensing. However, the development of high-performance deep-UV laser diodes is still limited by poor hole injection, which comes...

A Normal Map-Based Proximal Stochastic Gradient Method: Convergence and Identification Properties

Abstract. The proximal stochastic gradient method ([Formula: see text]) is one of the state-of-the-art approaches for stochastic composite-type problems. In contrast to its deterministic counterpart, [Formula: see text] has been found to have difficulties with the correct identif...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Experimental causal inference from measurements alone in the presence of spatial and temporal quantum correlations

The causal structure of a set of events specifies which events influence which others. Determining this structure, known as causal inference, is a fundamental task in science. Reset-style intervention is commonly used to determine causal structure in classical scenarios. However,...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis

Background: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. Methods: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wa...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

Global South in transition: Geopolitical dynamics and development cooperation

Abstract This special issue explores the development trajectories of the Global South and how various regions of the Global South are navigating the increasingly complex geopolitical dynamics. Covering Africa, Asia, and Latin America, the collection examines both global and regio...

Lighting up Metal Nanoclusters as Promising Molecular Emitters

Atomically precise metal nanoclusters (NCs) have emerged as promising optical materials in recent years. At the transition size between metal atoms and plasmonic metal nanoparticles, metal NCs exhibit elusive mechanisms underlying their photoluminescence (PL) properties. This fun...

Counterfactual load forecasting with LLM-structured events and representation learning

News-reported social, environmental, and grid events can substantially reshape electricity demand, yet quantifying how such events perturb forecasted load trajectories remains largely unaddressed. Existing news-augmented forecasting studies use news as auxiliary features to reduc...

Unraveling the hormonal causality in postpartum depression: findings from a two-sample Mendelian randomization study

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...